Browsing Harvard Medical School by Title
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Hemizygous Deletion on Chromosome 3p26.1 Is Associated with Heavy Smoking among African American Subjects in the COPDGene Study
(Public Library of Science, 2016)Many well-powered genome-wide association studies have identified genetic determinants of self-reported smoking behaviors and measures of nicotine dependence, but most have not considered the role of structural variants, ... -
Hemodynamic Environments from Opposing Sides of Human Aortic Valve Leaflets Evoke Distinct Endothelial Phenotypes In Vitro
(Springer US, 2010)The regulation of valvular endothelial phenotypes by the hemodynamic environments of the human aortic valve is poorly understood. The nodular lesions of calcific aortic stenosis (CAS) develop predominantly beneath the ... -
Hemodynamic Impact of a Spontaneous Cervical Dissection on an Ipsilateral Saccular Aneurysm
(Korean Society of Cerebrovascular Surgeons; Society of Korean Endovascular Neurosurgeons, 2016)The dynamic, hemodynamic impact of a cervical dissection on an ipsilateral, intracranial saccular aneurysm has not been well illustrated. This 45-year-old female was found to have a small, supraclinoid aneurysm ipsilateral ... -
Hemoglobin \(A_{1c}\) as a Predictor of Incident Diabetes
(American Diabetes Association, 2011)Objective: Several studies have suggested that \(HbA_{1c}\) levels may predict incident diabetes. With new recommendations for use of \(HbA_{1c}\) in diagnosing diabetes, many patients with \(HbA_{1c}\) results below the ... -
Hemoglobin A1c and Arterial and Ventricular Stiffness in Older Adults
(Public Library of Science, 2012)Objective: Arterial and ventricular stiffening are characteristics of diabetes and aging which confer significant morbidity and mortality; advanced glycation endproducts (AGE) are implicated in this stiffening pathophysiology. ... -
Hemoglobin A1c Is Associated With Increased Risk of Incident Coronary Heart Disease Among Apparently Healthy, Nondiabetic Men and Women
(Blackwell Publishing Ltd, 2013)Background: Hemoglobin A1c (HbA1c), a time‐integrated marker of glycemic control, predicts risk of coronary heart disease (CHD) among diabetics. Few studies have examined HbA1c and risk of CHD among women and men without ... -
Hemoglobin A1c Levels and Aortic Arterial Stiffness: The Cardiometabolic Risk in Chinese (CRC) Study
(Public Library of Science, 2012)Objective: The American Diabetes Association (ADA) recently published new clinical guidelines in which hemoglobin A1c (HbA1c) was recommended as a diagnostic test for diabetes. The present study was to investigate the ... -
Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis
(Frontiers Media S.A., 2014)Mutations in hemojuvelin (HJV) are the most common cause of the juvenile-onset form of the iron overload disorder hereditary hemochromatosis. The discovery that HJV functions as a co-receptor for the bone morphogenetic ... -
Hemopexin in severe inflammation and infection: mouse models and human diseases
(BioMed Central, 2015)Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. Extracellular hemoglobin and secondarily released heme amplify inflammation in the presence of microbial TLR ligands and/or ... -
Hemorrhage After Manual Removal of the Placenta: Weighing Risk Factors and the Role of the Third Stage of Labor
(2018-05-15)Introduction: Manual removal of the placenta, often due to uterine atony or an abnormally adherent placenta, can be accompanied by severe maternal postpartum hemorrhage. The objective of this study was to identify risk ... -
Hemorrhage from Extra-Antral Gastric Antral Vascular Ectasia in a Patient with Duodenal Heterotopic Gastric Mucosa
(Hindawi Publishing Corporation, 2016)Gastric antral vascular ectasias (GAVE) have been increasingly recognized as an uncommon cause of chronic gastrointestinal bleeding and anemia, although their underlying pathogenesis is not completely well understood. ... -
Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing β-Methylphenyl-ethylamine (BMPEA): A Case Report
(American College of Physicians, 2015-06-16) -
Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation
(Springer US, 2013)The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone regions of the circulation ... -
Heparan sulphate proteoglycans: the sweet side of development
(Nature Research (part of Springer Nature), 2005)Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. ... -
Heparin affinity purification of extracellular vesicles
(Nature Publishing Group, 2015)Extracellular vesicles (EVs) are lipid membrane vesicles released by cells. They carry active biomolecules including DNA, RNA, and protein which can be transferred to recipient cells. Isolation and purification of EVs from ... -
Heparin requirements for full anticoagulation are higher for patients on dabigatran than for those on warfarin – a model-based study
(Dove Medical Press, 2015)Purpose Dabigatran (D) is increasingly used for chronic anticoagulation in place of warfarin (W). These patients may present for catheter-based procedures requiring full anticoagulation with heparin. This study compares ... -
Heparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal Domain
(American Society for Biochemistry and Molecular Biology, 2008)Through its interactions with proteins and proteoglycans, thrombospondin-1 (TSP-1) functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular phenotype. We have ... -
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
(National Academy of Sciences, 2017)The neonatal crystallizable fragment receptor (FcRn) is responsible for maintaining the long half-life and high levels of the two most abundant circulating proteins, albumin and IgG. In the latter case, the protective ... -
Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability
(2015)BACKGROUND & AIMS Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. ...