Browsing Harvard Medical School by Title

Now showing items 7676-7695 of 18426

    • The Hepatitis C Cascade of Care: Identifying Priorities to Improve Clinical Outcomes 

      Linas, Benjamin P.; Barter, Devra M.; Leff, Jared A.; Assoumou, Sabrina A.; Salomon, Joshua A.; Weinstein, Milton C.; Kim, Arthur Y.; Schackman, Bruce R. (Public Library of Science, 2014)
      Background: As highly effective hepatitis C virus (HCV) therapies emerge, data are needed to inform the development of interventions to improve HCV treatment rates. We used simulation modeling to estimate the impact of ...

    • Hepatitis C Virus and Hepatocarcinogenesis 

      Jeong, Soung Won; Jang, Jae Young; Chung, Raymond Taeyong (The Korean Association for the Study of the Liver, 2012)
      Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The oncogenic process of HCV infection is slow ...

    • Hepatitis C Virus Cell-Cell Transmission and Resistance to Direct-Acting Antiviral Agents 

      Xiao, Fei; Fofana, Isabel; Heydmann, Laura; Barth, Heidi; Soulier, Eric; Habersetzer, François; Doffoël, Michel; Bukh, Jens; Patel, Arvind H.; Zeisel, Mirjam B.; Baumert, Thomas F. (Public Library of Science, 2014)
      Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes. Viral cell-cell transmission has been shown to play an important ...

    • Hepatitis C Virus Infection Protein Network 

      de Chassey, B; Navratil, V; Tafforeau, L; Hiet, M S; Aublin-Gex, A; Agaugué, S; Meiffren, G; Pradezynski, F; Faria, B F; Chantier, T; Le Breton, M; Pellet, J; Davoust, N; Mangeot, P E; Chaboud, A; Penin, F; Jacob, Y; Vidalain, P O; Vidal, Marc; André, P; Rabourdin-Combe, C; Lotteau, V (Nature Publishing Group, 2008)
      A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein–protein interactions between HCV ...

    • Hepatitis C virus NS3‐4A inhibits the peroxisomal MAVS‐dependent antiviral signalling response 

      Ferreira, Ana R.; Magalhães, Ana C.; Camões, Fátima; Gouveia, Ana; Vieira, Marta; Kagan, Jonathan C.; Ribeiro, Daniela (John Wiley and Sons Inc., 2016)
      Abstract Hepatitis C virus (HCV) is the cause of one of the most prevalent viral infections worldwide. Upon infection, the HCV genome activates the RIG‐I‐MAVS signalling pathway leading to the production of direct antiviral ...

    • Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention 

      Baffy, György (XIA & HE Publishing Ltd, 2013)
      Hepatocellular cancer (HCC) is the fifth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Non-alcoholic fatty liver disease (NAFLD), a spectrum of hepatic disorders associated with ...

    • Hepatocyte Growth Factor Induces Retinal Vascular Permeability via MAP-Kinase and PI-3 Kinase without Altering Retinal Hemodynamics 

      Clermont, Allen Charles; Cahill, Mark; Salti, Haytham; Rook, Susan L.; Rask-Madsen, Christian; Goddard, Lucy; Wong, Jun S.; Bursell, Dahlia; Bursell, Sven E.; Aiello, Lloyd Paul (Association for Research in Vision and Ophthalmology (ARVO), 2006)
      Purpose. Although vascular endothelial growth factor (VEGF) is a key mediator of retinal vascular permeability (RVP), there may be additional humoral contributors. Hepatocyte growth factor (HGF) induces endothelial cell ...

    • Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes 

      Morena, Deborah; Maestro, Nicola; Bersani, Francesca; Forni, Paolo Emanuele; Lingua, Marcello Francesco; Foglizzo, Valentina; Šćepanović, Petar; Miretti, Silvia; Morotti, Alessandro; Shern, Jack F; Khan, Javed; Ala, Ugo; Provero, Paolo; Sala, Valentina; Crepaldi, Tiziana; Gasparini, Patrizia; Casanova, Michela; Ferrari, Andrea; Sozzi, Gabriella; Chiarle, Roberto; Ponzetto, Carola; Taulli, Riccardo (eLife Sciences Publications, Ltd, 2016)
      Embryonal Rhabdomyosarcoma (ERMS) and Undifferentiated Pleomorphic Sarcoma (UPS) are distinct sarcoma subtypes. Here we investigate the relevance of the satellite cell (SC) niche in sarcoma development by using Hepatocyte ...

    • Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent 

      Wu, Xinggang; Yung, Lai-Ming; Cheng, Wai-Hang; Yu, Paul B.; Babitt, Jodie L.; Lin, Herbert Yih-Fuu; Xia, Yin (Public Library of Science, 2012)
      Hepcidin is an antimicrobial peptide, which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages. Hepcidin is synthesized mainly in the liver, ...

    • HER-2-Targeted Nanoparticle-Affibody Bioconjugates for Cancer Therapy 

      Alexis, Frank; Basto, Pamela; Levy-Nissenbaum, Etgar; Radovic-Moreno, Aleksandar F.; Zhang, Liangfang; Pridgen, Eric; Wang, Andrew Z.; Marein, Shawn L.; Westerhof, Katrina; Molnar, Linda K.; Farokhzad, Omid Cameron (Wiley-Blackwell, 2008)
      Affibodies are a class of polypeptide ligands that are potential candidates for cell- or tissue-specific targeting of drug-encapsulated controlled release polymeric nanoparticles (NPs). Here we report the development of ...

    • HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy 

      Perera, Samanthi A.; Li, Danan; Shimamura, Takeshi; Raso, Maria G.; Ji, Hongbin; Chen, Liang; Borgman, Christa L.; Zaghlul, Sara; Brandstetter, Kathleyn A.; Kubo, Shigeto; Takahashi, Masaya; Chirieac, Lucian R.; Padera, Robert F.; Bronson, Roderick T.; Shapiro, Geoffrey I.; Greulich, Heidi; Meyerson, Matthew; Guertler, Ulrich; Chesa, Pilar Garin; Solca, Flavio; Wistuba, Ignacio I.; Wong, Kwok-Kin (National Academy of Sciences, 2009)
      Mutations in the HER2 kinase domain have been identified in human clinical lung cancer specimens. Here we demonstrate that inducible expression of the most common HER2 mutant (HER2(YVMA)) in mouse lung epithelium causes ...

    • Heritability analysis with repeat measurements and its application to resting-state functional connectivity 

      Ge, Tian; Holmes, Avram; Buckner, Randy; Smoller, Jordan; Sabuncu, Mert (National Academy of Sciences, 2017)
      Heritability, defined as the proportion of phenotypic variation attributable to genetic variation, provides important information about the genetic basis of a trait. Existing heritability analysis methods do not discriminate ...

    • Heritability of Thoracic Spine Curvature and Genetic Correlations With Other Spine Traits: The Framingham Study 

      Yau, Michelle Szu-Huei; Demissie, Serkalem; Zhou, Yanhua; Anderson, Dennis Earl; Lorbergs, Amanda L; Kiel, Douglas P; Allaire, Brett T; Yang, Laiji; Cupples, L Adrienne; Travison, Thomas G; Bouxsein, Mary Larsen; Karasik, David; Samelson, Elizabeth J. (Wiley, 2016)
      Hyperkyphosis is a common spinal disorder in older adults, characterized by excessive forward curvature of the thoracic spine and adverse health outcomes. The etiology of hyperkyphosis has not been firmly established, but ...

    • Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System 

      Hwang, Woong Y.; Fu, Yanfang; Reyon, Deepak; Maeder, Morgan L.; Kaini, Prakriti; Sander, Jeffry D.; Joung, J. Keith; Peterson, Randall T.; Yeh, Jing-Ruey Joanna (Public Library of Science, 2013)
      We have previously reported a simple and customizable CRISPR (clustered regularly interspaced short palindromic repeats) RNA-guided Cas9 nuclease (RGN) system that can be used to efficiently and robustly introduce somatic ...

    • Heritable genome editing in C. elegans via a CRISPR-Cas9 system 

      Friedland, Ari E.; Tzur, Yonatan B.; Esvelt, Kevin M.; Colaiácovo, Monica P.; Church, George M.; Calarco, John A. (2013)
      CRISPR-Cas systems have been used with single-guide RNAs for accurate gene disruption and conversion in multiple biological systems. Here we report the use of the endonuclease Cas9 to target genomic sequences in the C. ...

    • Heritable Stochastic Switching Revealed by Single-Cell Genealogy 

      Kaufmann, Benjamin Bailey; Yang, Qiong; Mettetal, Jerome T; van Oudenaarden, Alexander (Public Library of Science, 2007)
      The partitioning and subsequent inheritance of cellular factors like proteins and RNAs is a ubiquitous feature of cell division. However, direct quantitative measures of how such nongenetic inheritance affects subsequent ...

    • Herpes Simplex Keratitis and Dendritic Cells at the Crossroads 

      Hamrah, Pedram; Pavan-Langston, Deborah; Dana, Reza (Ovid Technologies (Wolters Kluwer Health), 2009)

    • Herpes Simplex Virus 1 Immediate-Early and Early Gene Expression during Reactivation from Latency under Conditions That Prevent Infectious Virus Production 

      Pesola, Jean; Zhu, Jia; Knipe, David; Coen, Donald (American Society for Microbiology, 2005)
      The program of gene expression exhibited by herpes simplex virus during productive infection of cultured cells is well established; however, less is known about the regulatory controls governing reactivation from latency ...

    • Herpes Simplex Virus Is Equipped with RNA- and Protein-Based Mechanisms to Repress Expression of ATRX, an Effector of Intrinsic Immunity 

      Jurak, Igor; Silverstein, Leah B.; Sharma, Mayuri; Coen, Donald M. (American Society for Microbiology, 2012)
      Intrinsic immunity is a first-line intracellular defense against virus infection, and viruses have evolved mechanisms to counteract it. During herpes simplex virus (HSV) infection, nuclear domain 10 (ND10) components ...

    • Herpes Simplex Virus Mutants with Multiple Substitutions Affecting DNA Binding of UL42 Are Impaired for Viral Replication and DNA Synthesis 

      Jiang, Changying; Hwang, Ying T.; Wang, Guangliang; Randell, John W.; Coen, Donald M.; Hwang, Charles C. (American Society for Microbiology, 2007)
      Herpes simplex virus mutants with single substitutions that decrease DNA binding by the DNA polymerase processivity subunit UL42 are only modestly impaired for viral replication. In this study, recombinant viruses harboring ...