Browsing Harvard Medical School by Title
Now showing items 7704-7723 of 18428
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Heterogeneity in Macrophage Phagocytosis of Staphylococcus aureus Strains: High-Throughput Scanning Cytometry-Based Analysis
(Public Library of Science, 2009)Alveolar macrophages (AMs) can phagocytose unopsonized pathogens such as S. aureus via innate immune receptors, such as scavenger receptors (SRs). Cytoskeletal events and signaling pathways involved in phagocytosis of ... -
Heterogeneity of B cell helper T cells in murine pristane-induced lupus
(2023-05-10)T follicular helper (Tfh) cells are considered the major T cells capable of stimulating B cells responses, and these cells can promote germinal center responses and autoantibody production in autoimmune diseases. However, ... -
The heterogeneity of clinical practice patterns among an international cohort of pulmonary arterial hypertension experts
(University of Chicago Press, 2014)Abstract The extent to which pulmonary arterial hypertension (PAH) experts share common practice patterns that are in alignment with published expert consensus recommendations is unknown. Our objective was to characterize ... -
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
(Nature Pub. Group, 2014)Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number profiling and cytogenetics to analyse 84 myeloma ... -
Heterogeneity of the Tumor Vasculature: The Need for New Tumor Blood Vessel Type-Specific Targets
(Springer Netherlands, 2012)Therapies directed against VEGF-A and its receptors are effective in treating many mouse tumors but have been less so in treating human cancer patients. To elucidate the reasons that might be responsible for this difference ... -
Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis
(American Heart Association, 2009)Monocytes and macrophages play active roles in atherosclerosis, a chronic inflammatory disease that is a leading cause of death in the developed world. The prevailing paradigm states that, during human atherogenesis, ... -
Heterohexamer of 56- and 63-kDa Gene 4 Helicase-Primase of Bacteriophage T7 in DNA Replication
(American Society for Biochemistry and Molecular Biology, 2012)Bacteriophage T7 expresses two forms of gene 4 protein (gp4). The 63-kDa full-length gp4 contains both the helicase and primase domains. T7 phage also express a 56-kDa truncated gp4 lacking the zinc binding domain of the ... -
Heterozygosity for Fibrinogen Results in Efficient Resolution of Kidney Ischemia Reperfusion Injury
(Public Library of Science, 2012)Fibrinogen (Fg) has been recognized to play a central role in coagulation, inflammation and tissue regeneration. Several studies have used Fg deficient mice (Fg−/−) in comparison with heterozygous mice (Fg+/−) to point the ... -
Heterozygous disruption of Flk-1 receptor leads to myocardial ischaemia reperfusion injury in mice: application of affymetrix gene chip analysis
(Blackwell Publishing Ltd, 2008)This study addresses an important clinical issue by identifying potential candidates of vascular endothelial growth factor (VEGF) signalling through the Flk-1 receptor that trigger cardioprotective signals under ischaemic ... -
Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice
(American Society for Clinical Investigation, 1998)Previous studies of osteopetrotic (op) mice lacking macrophage colony-stimulating factor (M-CSF) have revealed an inhibition of atherosclerosis development in the apolipoprotein E (apo E)-deficient model and in a diet-induced ... -
The Hexamer Structure of the Rift Valley Fever Virus Nucleoprotein Suggests a Mechanism for its Assembly into Ribonucleoprotein Complexes
(Public Library of Science, 2011)Rift Valley fever virus (RVFV), a Phlebovirus with a genome consisting of three single-stranded RNA segments, is spread by infected mosquitoes and causes large viral outbreaks in Africa. RVFV encodes a nucleoprotein (N) ... -
HFE Gene Variants Modify the Association between Maternal Lead Burden and Infant Birthweight: A Prospective Birth Cohort Study in Mexico City, Mexico
(BioMed Central, 2010)Background: Neonatal growth is a complex process involving genetic and environmental factors. Polymorphisms in the hemochromatosis (HFE) iron regulatory genes have been shown to modify transport and toxicity of lead which ... -
HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: the normative aging study
(National Institute of Environmental Health Sciences, 2010)Background: Cumulative lead exposure is associated with a widened pulse pressure (PP; the difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. ... -
HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature
(Hindawi Publishing Corporation, 2013)Primary effusion lymphoma (PEL) is a rare extranodal lymphoma that typically presents in a body cavity in the absence of a detectable tumor mass and that occurs predominantly in immunosuppressed individuals. The neoplastic ... -
The hidden societal cost of antibiotic resistance per antibiotic prescribed in the United States: an exploratory analysis
(BioMed Central, 2016)Background: Ambulatory antibiotic prescribing contributes to the development of antibiotic resistance and increases societal costs. Here, we estimate the hidden societal cost of antibiotic resistance per antibiotic prescribed ... -
Hiding in plain view: the potential for commonly used drugs to reduce breast cancer mortality
(BioMed Central, 2012)Many medications have been developed for one purpose but then are found to have other clinical activities. There is tremendous interest in whether non-cancer medications may potentially have effects on breast cancer survival. ... -
A Hierarchical Algorithm for MR Brain Image Parcellation
(Institute of Electrical and Electronics Engineers (IEEE), 2007)We introduce an algorithm for segmenting brain magnetic resonance (MR) images into anatomical compartments such as the major tissue classes and neuro-anatomical structures of the gray matter. The algorithm is guided by ... -
A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples
(BioMed Central, 2008)Background: One of the challenges of the analysis of pooling-based genome wide association studies is to identify authentic associations among potentially thousands of false positive associations. Results: We present a ... -
Hierarchical regulation of the genome: global changes in nucleosome organization potentiate genome response
(Impact Journals LLC, 2016)Nucleosome occupancy is critically important in regulating access to the eukaryotic genome. Few studies in human cells have measured genome-wide nucleosome distributions at high temporal resolution during a response to a ... -
Hierarchical Rules for Argonaute Loading in Drosophila
(Elsevier BV, 2009-11)Drosophila Argonaute-1 and Argonaute-2 differ in function and small RNA content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by microRNAs. MicroRNA duplexes are intrinsically asymmetric, with one ...