Browsing Harvard Medical School by Title
Now showing items 7971-7990 of 18423
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Honey’s Ability to Counter Bacterial Infections Arises from Both Bactericidal Compounds and QS Inhibition
(Frontiers Research Foundation, 2012)The ability of honey to kill bacterial pathogens in vitro and quickly clear even chronic or drug-resistant infections has been demonstrated by several studies. Most current research is focused on identifying the bactericidal ... -
Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion
(National Academy of Sciences, 2008)Many DNA-interacting proteins diffuse on DNA to perform their biochemical functions. Processivity factors diffuse on DNA to permit unimpeded elongation by their associated DNA polymerases, but little is known regarding ... -
Horizontal Gene Acquisitions, Mobile Element Proliferation, and Genome Decay in the Host-Restricted Plant Pathogen Erwinia Tracheiphila
(Oxford University Press, 2016)Modern industrial agriculture depends on high-density cultivation of genetically similar crop plants, creating favorable conditions for the emergence of novel pathogens with increased fitness in managed compared with ... -
Horizontal gene transfer and the genomics of enterococcal antibiotic resistance
(Elsevier BV, 2010)Enterococci are Gram-positive bacteria that normally colonize gastrointestinal tracts of humans and animals. They are of growing concern because of their ability to cause antibiotic resistant hospital infections. Antibiotic ... -
Hormonal and Reproductive Risk Factors for Epithelial Ovarian Cancer by Tumor Aggressiveness
(American Association for Cancer Research (AACR), 2013)Background Approximately half of epithelial ovarian cancers are fatal within three years; however about 35% of women survive at least ten years. In the Nurses’ Health Study, New England Case-Control Study, Australian ... -
The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis
(BioMed Central, 2014)Ovulation has long been associated with an increased risk in ovarian cancer, yet the underlying molecular mechanisms remain obscure. Two aspects of ovulation have been linked to ovarian cancer pathogenesis. The first is ... -
Hormone Replacement Therapy and Dry Eye Syndrome
(American Medical Association (AMA), 2001)Context Postmenopausal hormone replacement therapy (HRT) use is common in the United States. Some research suggests that estrogen may have detrimental effects on the tear film and could influence the development of dry eye ... -
Hormone Resistance in Diabetes and Obesity: Insulin, Leptin, and FGF21
(YJBM, 2012)This an edited transcript of the Lee E. Farr Lecture given by Dr. Jeffrey Flier on May 8, 2012, at the culmination of the annual Student Research Day at the Yale School of Medicine. In this presentation, Dr. Flier discusses ... -
Hospice Use Following Implantable Cardioverter-Defibrillator Implantation in Older Patients: Results From the National Cardiovascular Data Registry
(Lippincott Williams & Wilkins, 2016)Background— Older recipients of implantable cardioverter-defibrillators (ICDs) are at increased risk for short-term mortality in comparison with younger patients. Although hospice use is common among decedents aged >65, ... -
Hospital Acquired Infections in Low and Middle Income Countries: Root Cause Analysis and the Development of Infection Control Practices in Bangladesh
(Scientific Research Publishing, Inc,, 2016-01)Nosocomial or hospital acquired infections are a major challenge for low and middle income countries (LMICs) which have limited healthcare resources. Risk factors include the lack of appropriate hospital facilities such ... -
Hospital Acquired Pneumonia Is Linked to Right Hemispheric Peri-Insular Stroke
(Public Library of Science, 2013)Purpose Hospital acquired pneumonia (HAP) is a major complication of stroke. We sought to determine associations between infarction of specific brain regions and HAP. Methods: 215 consecutive acute stroke patients with HAP ... -
Hospital at Home: Feasibility and Outcomes of a Program To Provide Hospital-Level Care at Home for Acutely Ill Older Patients
(American College of Physicians, 2005)Background: Acutely ill older persons often experience adverse events when cared for in the acute care hospital. Objective: To assess the clinical feasibility and efficacy of providing acute hospital-level care in a patient's ... -
Hospital Board and Management Practices are Strongly Related to Hospital Performance on Clinical Quality Metrics
(2015)National policies to improve health care quality have largely focused on clinical provider outcomes and, more recently, payment reform. Yet the association between hospital leadership and quality, although crucial to driving ... -
Hospital case volume and outcomes for proximal femoral fractures in the USA: an observational study
(BMJ Publishing Group, 2016)Objective: To explore whether older adults with isolated hip fractures benefit from treatment in high-volume hospitals. Design: Population-based observational study. Setting: All acute hospitals in California, USA. ... -
Hospital Readmission in General Medicine Patients: A Prediction Model
(Springer-Verlag, 2009)Background: Previous studies of hospital readmission have focused on specific conditions or populations and generated complex prediction models. Objective: To identify predictors of early hospital readmission in a diverse ... -
Hospital Surgical Volume, Utilization, Costs and Outcomes of Retroperitoneal Lymph Node Dissection for Testis Cancer
(Hindawi Publishing Corporation, 2012)Objectives: Retroperitoneal lymph node dissection (RPLND) outcomes for testis cancer originate mostly from single-center series. We characterized population-based utilization, costs, and outcomes and assessed whether higher ... -
Hospital Variation in Premature Clopidogrel Discontinuation After Drug‐Eluting Stent Placement in the Veterans Affairs (VA) Healthcare System
(John Wiley and Sons Inc., 2016)Background: Premature clopidogrel discontinuation after drug‐eluting stent placement is associated with adverse outcomes. Little is known about patient and hospital factors associated with premature discontinuation or ... -
Hospitalized Patients at High Risk for Obstructive Sleep Apnea Have More Rapid Response System Events and Intervention Is Associated with Reduced Events
(Public Library of Science, 2016)Background: Rapid response system (RRS) is a safety tool designed for early detection and intervention of a deteriorating patient on the general floor in the hospital. Obstructive sleep apnea (OSA) has been associated with ... -
Host and Bacterial Proteins That Repress Recruitment of LC3 to Shigella Early during Infection
(Public Library of Science, 2014)Shigella spp. are intracytosolic gram-negative pathogens that cause disease by invasion and spread through the colonic mucosa, utilizing host cytoskeletal components to form propulsive actin tails. We have previously ... -
Host and viral determinants for MxB restriction of HIV-1 infection
(BioMed Central, 2014)Background: Interferon-induced cellular proteins play important roles in the host response against viral infection. The Mx family of dynamin-like GTPases, which include MxA and MxB, target a wide variety of viruses. Despite ...