Browsing Harvard Medical School by Title

Now showing items 8167-8186 of 18428

    • Hypertrophic Pachymeningitis and Cerebral Venous Sinus Thrombosis in Inflammatory Bowel Disease 

      Xia, Zongqi; Chen-Plotkin, Alice; Schmahmann, Jeremy (Elsevier BV, 2010-11)
      Hypertrophic pachymeningitis is rarely observed in inflammatory bowel disease. We report a woman with ulcerative colitis whose biopsy-confirmed hypertrophic pachymeningitis was complicated by cerebral venous sinus thrombosis ...

    • Hypofractionated Radiotherapy and Stereotactic Boost with Concurrent and Adjuvant Temozolamide for Glioblastoma in Good Performance Status Elderly Patients – Early Results of a Phase II Trial 

      Floyd, Scott Richard; Kasper, Ekkehard Matthias; Uhlmann, Erik J; Fonkem, Ekokobe; Wong, Eric T.; Mahadevan, Anand (Frontiers Media S.A., 2012)
      Glioblastoma Multiforme (GBM) is an aggressive primary brain neoplasm with dismal prognosis. Based on successful phase III trials, 60 Gy involved-field radiotherapy in 30 fractions over 6 weeks [Standard radiation therapy ...

    • Hypoglycemia and Clinical Outcomes in Patients With Diabetes Hospitalized in the General Ward 

      Turchin, Alexander; Matheny, Michael E.; Shubina, Maria; Scanlon, James V.; Greenwood, Bonnie; Pendergrass, Merri L. (American Diabetes Association, 2009)
      OBJECTIVE: Hypoglycemia is associated with adverse outcomes in mixed populations of patients in intensive care units. It is not known whether the same risks exist for diabetic patients who are less severely ill. In this ...

    • Hypoglycemia, With or Without Insulin Therapy, Is Associated With Increased Mortality Among Hospitalized Patients 

      Garg, Rajesh; Hurwitz, Shelley; Turchin, Alexander; Trivedi, Apoorva (American Diabetes Association, 2013)
      OBJECTIVE Hypoglycemia is associated with increased mortality in hospitalized patients. We investigated the relationship between spontaneous hypoglycemia versus insulin-associated hypoglycemia and mortality in hospitalized ...

    • Hypokalemia, Its Contributing Factors and Renal Outcomes in Patients with Chronic Kidney Disease 

      Wang, Hsiao-Han; Hung, Chi-Chih; Hwang, Daw-Yang; Kuo, Mei-Chuan; Chiu, Yi-Wen; Chang, Jer-Ming; Tsai, Jer-Chia; Hwang, Shang-Jyh; Seifter, Julian L.; Chen, Hung-Chun (Public Library of Science, 2013)
      Background: In the chronic kidney disease (CKD) population, the impact of serum potassium (sK) on renal outcomes has been controversial. Moreover, the reasons for the potential prognostic value of hypokalemia have not been ...

    • Hypothalamic kappa opioid receptor mediates both diet‐induced and melanin concentrating hormone–induced liver damage through inflammation and endoplasmic reticulum stress 

      Imbernon, Monica; Sanchez‐Rebordelo, Estrella; Romero‐Picó, Amparo; Kalló, Imre; Chee, Melissa J.; Porteiro, Begoña; Al‐Massadi, Omar; Contreras, Cristina; Fernø, Johan; Senra, Ana; Gallego, Rosalia; Folgueira, Cintia; Seoane, Luisa M.; van Gestel, Margriet; Adan, Roger A.; Liposits, Zsolt; Dieguez, Carlos; López, Miguel; Nogueiras, Ruben (John Wiley and Sons Inc., 2016)
      The opioid system is widely known to modulate the brain reward system and thus affect the behavior of humans and other animals, including feeding. We hypothesized that the hypothalamic opioid system might also control ...

    • Hypothalamus and amygdala response to acupuncture stimuli in carpal tunnel syndrome 

      Napadow, Vitaly J.; Kettner, N.; Liu, J.; Li, M.; Kwong, Kenneth Kin Man; Vangel, Mark G.; Makris, Nikolaos; Audette, Joseph F.; Hui, K. K.S. (Ovid Technologies (Wolters Kluwer Health), 2007)
      Brain processing of acupuncture stimuli in chronic neuropathic pain patients may underlie its beneficial effects. We used fMRI to evaluate verum and sham acupuncture stimulation at acupoint LI-4 in Carpal Tunnel Syndrome ...

    • Hypothermia in Bleeding Trauma: A Friend or a Foe? 

      Kheirbek, Tareq; Kochanek, Ashley R; Alam, Hasan B. (BioMed Central, 2009)
      The induction of hypothermia for cellular protection is well established in several clinical settings. Its role in trauma patients, however, is controversial. This review discusses the benefits and complications of induced ...

    • Hypothesis-Based Analysis of Gene-Gene Interactions and Risk of Myocardial Infarction 

      Lucas, Gavin; Lluís-Ganella, Carla; Subirana, Isaac; Musameh, Muntaser D.; Gonzalez, Juan Ramon; Nelson, Christopher P.; Sentí, Mariano; Schwartz, Stephen M.; Siscovick, David; O’Donnell, Christopher J.; Melander, Olle; Salomaa, Veikko; Samani, Nilesh J.; Kathiresan, Sekar; Elosua, Roberto; Purcell, Shaun; Altshuler, David Matthew (Public Library of Science, 2012)
      The genetic loci that have been found by genome-wide association studies to modulate risk of coronary heart disease explain only a fraction of its total variance, and gene-gene interactions have been proposed as a potential ...

    • Hypoxia Activates a Ca-Permeable Cation Conductance Sensitive to Carbon Monoxide and to GsMTx-4 in Human and Mouse Sickle Erythrocytes 

      Vandorpe, David Henry; Xu, Chang; Shmukler, Boris E.; Otterbein, Leo E.; Trudel, Marie; Sachs, Frederick; Gottlieb, Philip A.; Brugnara, Carlo; Alper, Seth Leo (Public Library of Science, 2010)
      Background: Deoxygenation of sickle erythrocytes activates a cation permeability of unknown molecular identity (Psickle), leading to elevated intracellular [Ca2+] ([Ca2+]i) and subsequent activation of KCa 3.1. The resulting ...

    • Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival 

      Schipani, Ernestina; Ryan, Heather E.; Didrickson, Susanna; Kobayashi, Tatsuya; Knight, Melissa; Johnson, Randall S. (Cold Spring Harbor Laboratory Press, 2001)

    • Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2 

      Wu, Connie; So, Jessica; Davis-Dusenbery, Brandi N.; Qi, Hank H.; Bloch, Donald B.; Shi, Yang; Lagna, Giorgio; Hata, Akiko (American Society for Microbiology, 2011)
      Hypoxia contributes to the pathogenesis of various human diseases, including pulmonary artery hypertension (PAH), stroke, myocardial or cerebral infarction, and cancer. For example, acute hypoxia causes selective pulmonary ...

    • Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. 

      Takagi, H; King, GL; Ferrara, N; Aiello, Lloyd Paul (1996)
      PURPOSE: Vascular endothelial growth factor (VEGF) is an endothelial cell-specific angiogenic factor that serves an important role in numerous ischemic retinopathies. The authors studied the hypoxic gene regulation of two ...

    • Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas 

      Yoon, C; Lee, H-J; Park, D J; Lee, Y-J; Tap, W D; Eisinger-Mathason, T S K; Hart, C P; Choy, E; Simon, M C; Yoon, S S (Nature Publishing Group, 2015)
      Background: Human sarcomas with a poor response to vascular endothelial growth factor-A (VEGF-A) inhibition and radiation therapy (RT) have upregulation of hypoxia-inducible factor 1α (HIF-1α) and HIF-1α target genes. This ...

    • Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis 

      Srinivasan, Srimathi; Chitalia, Vipul; Meyer, Rosana D.; Hartsough, Edward; Mehta, Manisha; Harrold, Itrat; Anderson, Nicole; Feng, Hui; Smith, Lois Elaine Hodgson; Jiang, Yan; Costello, Catherine E.; Rahimi, Nader (Springer Science + Business Media, 2015)
      Expression and activation of vascular endothelial growth factor receptor 2 (VEGFR-2) by VEGF ligands are the main events in the stimulation of pathological angiogenesis. VEGFR-2 expression is generally low in the healthy ...

    • “I Always Worry about What Might Happen Ahead”: Implementing Safer Conception Services in the Current Environment of Reproductive Counseling for HIV-Affected Men and Women in Uganda 

      Matthews, Lynn T.; Bajunirwe, Francis; Kastner, Jasmine; Sanyu, Naomi; Akatukwasa, Cecilia; Ng, Courtney; Rifkin, Rachel; Milford, Cecilia; Moore, Lizzie; Wilson, Ira B.; Bangsberg, David R.; Smit, Jennifer A.; Kaida, Angela (Hindawi Publishing Corporation, 2016)
      Background. We explored healthcare provider perspectives and practices regarding safer conception counseling for HIV-affected clients. Methods. We conducted semistructured interviews with 38 providers (medical and clinical ...

    • An i2b2-based, generalizable, open source, self-scaling chronic disease registry 

      Natter, Marc D; Quan, Justin; Ortiz, David M; Bousvaros, Athos; Ilowite, Norman T; Inman, Christi J; Marsolo, Keith; McMurry, Andrew J; Sandborg, Christy I; Schanberg, Laura E; Wallace, Carol A; Warren, Robert W; Weber, Griffin M; Mandl, Kenneth D (BMJ Group, 2012)
      Objective: Registries are a well-established mechanism for obtaining high quality, disease-specific data, but are often highly project-specific in their design, implementation, and policies for data use. In contrast to the ...

    • IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans 

      Pearce, Neil; Blair, Aaron; Vineis, Paolo; Ahrens, Wolfgang; Andersen, Aage; Anto, Josep M.; Armstrong, Bruce K.; Baccarelli, Andrea A.; Beland, Frederick A.; Berrington, Amy; Bertazzi, Pier Alberto; Birnbaum, Linda S.; Brownson, Ross C.; Bucher, John R.; Cantor, Kenneth P.; Cardis, Elisabeth; Cherrie, John W.; Christiani, David C.; Cocco, Pierluigi; Coggon, David; Comba, Pietro; Demers, Paul A.; Dement, John M.; Douwes, Jeroen; Eisen, Ellen A.; Engel, Lawrence S.; Fenske, Richard A.; Fleming, Lora E.; Fletcher, Tony; Fontham, Elizabeth; Forastiere, Francesco; Frentzel-Beyme, Rainer; Fritschi, Lin; Gerin, Michel; Goldberg, Marcel; Grandjean, Philippe; Grimsrud, Tom K.; Gustavsson, Per; Haines, Andy; Hartge, Patricia; Hansen, Johnni; Hauptmann, Michael; Heederik, Dick; Hemminki, Kari; Hemon, Denis; Hertz-Picciotto, Irva; Hoppin, Jane A.; Huff, James; Jarvholm, Bengt; Kang, Daehee; Karagas, Margaret R.; Kjaerheim, Kristina; Kjuus, Helge; Kogevinas, Manolis; Kriebel, David; Kristensen, Petter; Kromhout, Hans; Laden, Francine; Lebailly, Pierre; LeMasters, Grace; Lubin, Jay H.; Lynch, Charles F.; Lynge, Elsebeth; ‘t Mannetje, Andrea; McMichael, Anthony J.; McLaughlin, John R.; Marrett, Loraine; Martuzzi, Marco; Merchant, James A.; Merler, Enzo; Merletti, Franco; Miller, Anthony; Mirer, Franklin E.; Monson, Richard; Nordby, Karl-Cristian; Olshan, Andrew F.; Parent, Marie-Elise; Perera, Frederica P.; Perry, Melissa J.; Pesatori, Angela Cecilia; Pirastu, Roberta; Porta, Miquel; Pukkala, Eero; Rice, Carol; Richardson, David B.; Ritter, Leonard; Ritz, Beate; Ronckers, Cecile M.; Rushton, Lesley; Rusiecki, Jennifer A.; Rusyn, Ivan; Samet, Jonathan M.; Sandler, Dale P.; de Sanjose, Silvia; Schernhammer, Eva; Costantini, Adele Seniori; Seixas, Noah; Shy, Carl; Siemiatycki, Jack; Silverman, Debra T.; Simonato, Lorenzo; Smith, Allan H.; Smith, Martyn T.; Spinelli, John J.; Spitz, Margaret R.; Stallones, Lorann; Stayner, Leslie T.; Steenland, Kyle; Stenzel, Mark; Stewart, Bernard W.; Stewart, Patricia A.; Symanski, Elaine; Terracini, Benedetto; Tolbert, Paige E.; Vainio, Harri; Vena, John; Vermeulen, Roel; Victora, Cesar G.; Ward, Elizabeth M.; Weinberg, Clarice R.; Weisenburger, Dennis; Wesseling, Catharina; Weiderpass, Elisabete; Zahm, Shelia Hoar (NLM-Export, 2015)
      Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used ...

    • IBC CARe Microarray Allelic Population Prevalences in an American Indian Population 

      Best, Lyle G.; Anderson, Cindy M.; Saxena, Richa; Almoguera, Berta; Chandrupatla, Hareesh; Martin, Candelaria; Falcon, Gilbert; Keplin, Kylie; Pearson, Nichole; Keating, Brendan J. (Public Library of Science, 2013)
      Background: The prevalence of variant alleles among single nucleotide polymorphisms (SNPs) is not well known for many minority populations. These population allele frequencies (PAFs) are necessary to guide genetic epidemiology ...

    • Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia 

      Treon, Steven; Tripsas, Christina K.; Meid, Kirsten; Warren, Diane; Varma, Gaurav; Green, Rebecca; Argyropoulos, Kimon V.; Yang, Guang; Cao, Yang; Xu, Lian; Patterson, Christopher J.; Rodig, Scott; Zehnder, James L.; Aster, Jon; Harris, Nancy; Kanan, Sandra; Ghobrial, Irene; Castillo, Jorge; Laubach, Jacob; Hunter, Zachary; Salman, Zeena; Li, Jianling; Cheng, Mei; Clow, Fong; Graef, Thorsten; Palomba, M. Lia; Advani, Ranjana H. (Massachusetts Medical Society, 2015-04-09)
      Background: MYD88(L265P) and CXCR4(WHIM) mutations are highly prevalent in Waldenström's macroglobulinemia. MYD88(L265P) triggers tumor-cell growth through Bruton's tyrosine kinase, a target of ibrutinib. CXCR4(WHIM) ...