Browsing Harvard Medical School by Title

Now showing items 8334-8353 of 18428

    • Identification of serum endoglin as a novel prognostic marker after acute myocardial infarction 

      Cruz-Gonzalez, Ignacio; Pabón, Pedro; Rodríguez-Barbero, Alicia; Martín-Moreiras, Javier; Pericacho, Miguel; Sánchez, Pedro L; Ramirez, Victor; Sánchez-Ledesma, María; Martín-Herrero, Francisco; Jiménez-Candil, Javier; Maree, Andrew O; Sánchez-Rodríguez, Angel; Martín-Luengo, Cándido; López-Novoa, José M (Blackwell Publishing Ltd, 2008)
      Abstract Endoglin is a proliferation-associated and hypoxia-inducible protein expressed in endothelial cells. The levels of soluble circulating endoglin and their prognostic significance in patients with acute myocardial ...

    • Identification of Small Molecule Inhibitors of Neurite Loss Induced by Aβ peptide using High Content Screening 

      Ofengeim, Dimitry; Shi, Peng; Miao, Benchun; Fan, Jing; Xia, Xiaofeng; Fan, Yubo; Lipinski, Marta; Hashimoto, Tadafumi; Polydoro, Manuela; Yuan, Junying; Wong, Stephen; Degterev, Alexei (American Society for Biochemistry and Molecular Biology, 2012)

    • Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen 

      Arnoldo, Anthony; Curak, Jasna; Kittanakom, Saranya; Chevelev, Igor; Sahebol-Amri, Mehdi; Koscik, Becky; Ljuma, Lana; Roy, Peter J.; Bedalov, Antonio; Giaever, Guri; Nislow, Corey; Merrill, Rod A.; Stagljar, Igor; Snyder, Michael; Lee, Vincent; Lory, Stephen (Public Library of Science, 2008)
      Pseudomonas aeruginosa is an opportunistic human pathogen that is a key factor in the mortality of cystic fibrosis patients, and infection represents an increased threat for human health worldwide. Because resistance of ...

    • Identification of small molecules for human hepatocyte expansion and iPS differentiation 

      Shan, Jing; Schwartz, Robert E.; Ross, Nathan T.; Logan, David J.; Thomas, David; Duncan, Stephen A.; North, Trista E.; Goessling, Wolfram; Carpenter, Anne E.; Bhatia, Sangeeta N. (2013)
      Cell-based therapies hold the potential to alleviate the growing burden of liver diseases. Such therapies require human hepatocytes, which, within the stromal context of the liver, are capable of many rounds of replication. ...

    • Identification of Small Molecules that Enhance Synaptogenesis Using Synapse Microarrays 

      Shi, Peng; Scott, Mark A; Ghosh, Balaram; Wan, Dongpeng; Wissner-Gross, Zachary; Mazitschek, Ralph; Haggarty, Stephen John; Yanik, Mehmet Fatih (Nature Publishing Group, 2011)
      Synaptic function is affected in many brain diseases and disorders. Technologies for large-scale synapse assays can facilitate identification of drug leads. Here we report a “synapse microarray” technology that enables ...

    • Identification of Small RNAs in Francisella tularensis 

      Postic, Guillaume; Frapy, Eric; Dupuis, Marion; Dubail, Iharilalao; Livny, Jonathan; Charbit, Alain; Meibom, Karin L (BioMed Central, 2010)
      Background: Regulation of bacterial gene expression by small RNAs (sRNAs) have proved to be important for many biological processes. Francisella tularensis is a highly pathogenic Gram-negative bacterium that causes the ...

    • Identification of sparsely distributed clusters of cis-regulatory elements in sets of co-expressed genes 

      Kreiman, Gabriel (Oxford University Press (OUP), 2004)
      Sequence information and high‐throughput methods to measure gene expression levels open the door to explore transcriptional regulation using computational tools. Combinatorial regulation and sparseness of regulatory elements ...

    • Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites 

      Swirski, Filip K.; Nahrendorf, Matthias; Etzrodt, Martin; Wildgruber, Moritz; Cortez-Retamozo, Virna; Panizzi, Peter; Figueiredo, Jose-Luiz; Kohler, Rainer H.; Chudnovskiy, Aleksey; Waterman, Peter; Aikawa, Elena; Mempel, Thorsten R.; Libby, Peter; Weissleder, Ralph; Pittet, Mikael J. (American Association for the Advancement of Science, 2009)
      A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we show that bona fide undifferentiated ...

    • Identification of subjects with polycystic ovary syndrome using electronic health records 

      Castro, Victor; Shen, Yuanyuan; Yu, Sheng; Finan, Sean; Pau, Cindy Ta; Gainer, Vivian; Keefe, Candace C.; Savova, Guergana; Murphy, Shawn N.; Cai, Tianxi; Welt, Corrine K. (BioMed Central, 2015)
      Background: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder because of the variable criteria used for diagnosis. Therefore, International Classification of Diseases 9 (ICD-9) codes may not accurately capture ...

    • Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair 

      Smogorzewska, Agata; Matsuoka, Shuhei; Vinciguerra, Patrizia; McDonald, E. Robert; Hurov, Kristen E.; Luo, Ji; Ballif, Bryan A.; Hofmann, Kay; D'Andrea, Alan D.; Elledge, Stephen; Gygi, Steven (Elsevier BV, 2007-04)
      Fanconi anemia (FA) is a developmental and cancer-predisposition syndrome caused by mutations in genes controlling DNA interstrand crosslink repair. Several FA proteins form a ubiquitin ligase that controls monoubiquitination ...

    • Identification of the Guanylyltransferase Region and Active Site in Reovirus mRNA Capping Protein λ2 

      Luongo, Cindy L.; Reinisch, Karin M.; Harrison, Stephen C.; Nibert, Max L. (American Society for Biochemistry and Molecular Biology, 2000)

    • Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis 

      Xie, Gang; Lu, Yue; Sun, Ye; Zhang, Steven Shiyang; Keystone, Edward Clark; Gregersen, Peter K; Plenge, Robert M; Amos, Christopher I; Siminovitch, Katherine A (BMJ Publishing Group, 2013)
      Objective: To fine-map the NF-κB activating protein-like (NKAPL) locus identified in a prior genome-wide study as a possible rheumatoid arthritis (RA) risk locus and thereby delineate additional variants with stronger ...

    • Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta 

      Kuzuya, Akira; Zoltowska, Katarzyna M.; Post, Kathryn L.; Arimon, Muriel; Li, Xuejing; Svirsky, Sarah; Maesako, Masato; Muzikansky, Alona; Gautam, Vivek; Kovacs, Dora; Hyman, Bradley T.; Berezovska, Oksana (BioMed Central, 2016)
      Background: Synaptic loss strongly correlates with memory deterioration. Local accumulation of amyloid β (Aβ) peptide, and neurotoxic Aβ42 in particular, due to abnormal neuronal activity may underlie synaptic dysfunction, ...

    • Identification of the SlmA Active Site Responsible for Blocking Bacterial Cytokinetic Ring Assembly over the Chromosome 

      Cho, Hongbaek; Bernhardt, Thomas G. (Public Library of Science, 2013)
      Bacterial cells use chromosome-associated division inhibitors to help coordinate the processes of DNA replication and segregation with cytokinesis. SlmA from Escherichia coli, a member of the tetracycline repressor (TetR)–like ...

    • Identification of the target self-antigens in reperfusion injury 

      Zhang, Ming; Alicot, Elisabeth M.; Chiu, Isaac; Li, Jinan; Verna, Nicola; Vorup-Jensen, Thomas; Kessler, Benedikt; Shimaoka, Motomu; Chan, Rodney; Friend, Daniel; Mahmood, Umar; Weissleder, Ralph; Moore, Francis D.; Carroll, Michael C. (Rockefeller University Press, 2006)

    • Identification of Thioredoxin Glutathione Reductase Inhibitors That Kill Cestode and Trematode Parasites 

      Ross, Fabiana; Hernández, Paola; Porcal, Williams; López, Gloria V.; Cerecetto, Hugo; González, Mercedes; Basika, Tatiana; Carmona, Carlos; Fló, Martín; Maggioli, Gabriela; Bonilla, Mariana; Boiani, Mariana; Salinas, Gustavo; Gladyshev, Vadim (Public Library of Science, 2012)
      Parasitic flatworms are responsible for serious infectious diseases that affect humans as well as livestock animals in vast regions of the world. Yet, the drug armamentarium available for treatment of these infections is ...

    • Identification of Toxemia in Patients with Clostridium difficile Infection 

      Yu, Hua; Chen, Kevin; Wu, Jianguo; Yang, Zhiyong; Shi, Lianfa; Barlow, Lydia L.; Aronoff, David M.; Garey, Kevin W.; Savidge, Tor C.; von Rosenvinge, Erik C.; Kelly, Ciaran P.; Feng, Hanping (Public Library of Science, 2015)
      Toxemia can develop in Clostridium difficile-infected animals, and correlates with severe and fulminant disease outcomes. Circumstantial evidence suggests that toxemia may occur in patients with C. difficile infection ...

    • Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics 

      Elias, Joshua E.; Maas, Stefan; Gygi, Steven P.; Selkoe, Dennis J.; Hemming, Matthew Louis (Public Library of Science, 2009)
      β-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis. BACE1 has been studied principally for ...

    • Identification, Localization, and Regulation of Expression of the UL24 Protein of Herpes Simplex Virus Type 1 

      Pearson, Angela; Coen, Donald M. (American Society for Microbiology, 2002)
      The UL24 gene of herpes simplex virus type 1 is conserved across many herpesviruses, but its protein product has not been identified. We expressed the UL24 gene in insect cells from a recombinant baculovirus and used the ...

    • Identifying candidate ncRNAs that direct changes in chromatin structure 

      Ray, Mridula Kumari; Wang, Yanqun; Borowsky, Mark L; Sadreyev, Ruslan; Kingston, Robert Edward (BioMed Central, 2013)