Browsing Harvard Medical School by Title
Now showing items 8790-8809 of 18428
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Improving transgender health by building safe clinical environments that promote existing resilience: Results from a qualitative analysis of providers
(BioMed Central, 2015)Background: Transgender (TG) individuals experience discordance between their sex at birth and their gender identity. To better understand the health care needs and characteristics of TG youth that contribute to resilience, ... -
Improving Treatment Intensification to Reduce Cardiovascular Disease Risk: A Cluster Randomized Trial
(BioMed Central, 2012)Background: Blood pressure, lipid, and glycemic control are essential for reducing cardiovascular disease (CVD) risk. Many health care systems have successfully shifted aspects of chronic disease management, including ... -
Improving Women's Health through Universal Health Coverage
(Public Library of Science, 2014)Jonathan Quick and colleagues discuss how women's health world-wide can be improved through universal health coverage. Please see later in the article for the Editors' Summary -
Impulsive Social Influence Increases Impulsive Choices on a Temporal Discounting Task in Young Adults
(Public Library of Science, 2014)Adolescents and young adults who affiliate with friends who engage in impulsive behavior are more likely to engage in impulsive behaviors themselves, and those who associate with prosocial (i.e. more prudent, future oriented) ... -
Impurity of Stem Cell Graft by Murine Embryonic Fibroblasts – Implications for Cell-Based Therapy of the Central Nervous System
(Frontiers Media S.A., 2014)Stem cells have been demonstrated to possess a therapeutic potential in experimental models of various central nervous system disorders, including stroke. The types of implanted cells appear to play a crucial role. Previously, ... -
Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens
(Public Library of Science, 2013)DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility to a wide range of human diseases. The complex genetic structure of the major histocompatibility complex (MHC) makes it difficult, ... -
Imputing gene expression from optimally reduced probe sets
(2012)Measuring complete gene expression profiles for a large number of experiments is costly. We propose an approach in which a small subset of probes is selected based on a preliminary set of full expression profiles. In ... -
In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core?
(Public Library of Science, 2015)Background and Purpose In the treatment of patients with suspected acute ischemic stroke, increasing evidence suggests the importance of measuring the volume of the irreversibly injured “ischemic core.” The gold standard ... -
In Bangla There Is No Word for Vagina—Reflections on Language, Sexual Health, and Women’s Access to Healthcare in Resource-Limited Countries
(Scientific Research Publishing, Inc,, 2016)Language plays a central role in how gender and sexuality are described. In Bangla or Bengali, physicians, when educating and counseling women patients, do not have a socially acceptable word for “vagina”. If language is ... -
In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
(Hindawi Publishing Corporation, 2016)Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, ... -
In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites
(Oxford University Press, 2013)Gene-editing nucleases enable targeted modification of DNA sequences in living cells, thereby facilitating efficient knockout and precise editing of endogenous loci. Engineered nucleases also have the potential to introduce ... -
In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems
(BioMed Central, 2012)Background: Mathematical models of dynamical systems facilitate the computation of characteristic properties that are not accessible experimentally. In cell biology, two main properties of interest are (1) the time-period ... -
In silico prediction of tumor antigens derived from functional missense mutations of the cancer gene census
(Landes Bioscience, 2012)Antigen-specific immune responses against peptides derived from missense gene mutations have been identified in multiple cancers. The application of personalized peptide vaccines based on the tumor mutation repertoire of ... -
In Silico Promoter Analysis can Predict Genes of Functional Relevance in Cell Proliferation: Validation in a Colon Cancer Model
(Sage, 2007-02)Specific combinations of transcription-factor binding sites in the promoter regions of genes regulate gene expression, and thus key functional processes in cells. Analysis of such promoter regions in specific functional ... -
in silico Surveillance: evaluating outbreak detection with simulation models
(BioMed Central, 2013)Background: Detecting outbreaks is a crucial task for public health officials, yet gaps remain in the systematic evaluation of outbreak detection protocols. The authors’ objectives were to design, implement, and test a ... -
In situ localized amplification and contact replication of many individual DNA molecules
(Oxford University Press (OUP), 1999-12-15)We describe a method to clone and amplify DNA by performing the polymerase chain reaction (PCR) in a thin polyacrylamide film poured on a glass microscope slide. The polyacrylamide matrix retards the diffusion of the linear ... -
In situ regeneration of bioactive coatings enabled by an evolved Staphylococcus aureus sortase A
(Nature Publishing Group, 2016)Surface immobilization of bioactive molecules is a central paradigm in the design of implantable devices and biosensors with improved clinical performance capabilities. However, in vivo degradation or denaturation of surface ... -
In situ single cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2+ breast cancer
(2015)Detection of minor genetically distinct subpopulations within tumors is a key challenge in cancer genomics. Here we report STAR-FISH (Specific-To-Allele PCR – FISH), a novel method for the combined detection of single ... -
In the Early Postpartum Period, Parents are Interested in Newborn Genomic Testing
(2014)Purpose We surveyed parents to ascertain interest in newborn genomic testing and determine whether these queries would provoke refusal of conventional newborn screening (NBS). Methods: After brief genetics orientation, ... -
In the Information Age, do dementia caregivers get the information they need? Semi-structured interviews to determine informal caregivers’ education needs, barriers, and preferences
(BioMed Central, 2016)Background: Most patients with dementia or cognitive impairment receive care from family members, often untrained for this challenging role. Caregivers may not access publicly available caregiving information, and caregiver ...