Browsing Harvard Medical School by Title

Now showing items 9119-9138 of 18428

    • Inherited Polymorphisms in Hyaluronan Synthase 1 Predict Risk of Systemic B-Cell Malignancies but Not of Breast Cancer 

      Kuppusamy, Hemalatha; Ogmundsdottir, Helga M.; Baigorri, Eva; Warkentin, Amanda; Steingrimsdottir, Hlif; Haraldsdottir, Vilhelmina; Mant, Michael J.; Mackey, John; Johnston, James B.; Adamia, Sophia; Belch, Andrew R.; Pilarski, Linda M. (Public Library of Science, 2014)
      Genetic variations in the hyaluronan synthase 1 gene (HAS1) influence HAS1 aberrant splicing. HAS1 is aberrantly spliced in malignant cells from multiple myeloma (MM) and Waldenstrom macroglobulinemia (WM), but not in their ...

    • Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes 

      Smyth, Deborah J.; Walker, Neil M.; Stevens, Helen; Burren, Oliver S.; Wallace, Chris; Greissl, Christopher; Ramos-Lopez, Elizabeth; Hyppönen, Elina; Dunger, David B.; Spector, Timothy D.; Ouwehand, Willem H.; Badenhoop, Klaus; Cooper, Jason D.; Wang, Thomas Jue-Fuu; Todd, John A. (American Diabetes Association, 2011)
      Objective: Vitamin D deficiency (25-hydroxyvitamin D [25(OH)D] <50 nmol/L) is commonly reported in both children and adults worldwide, and growing evidence indicates that vitamin D deficiency is associated with many ...

    • Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice 

      He, Chengwei; Qu, Xiying; Wan, Jianbo; Rong, Rong; Huang, Lili; Cai, Chun; Zhou, Keyuan; Gu, Yan; Qian, Steven Y.; Kang, Jing Xuan (Public Library of Science, 2012)
      Recent studies have shown that a tumor-supportive microenvironment is characterized by high levels of pro-inflammatory and pro-angiogenic eicosanoids derived from omega-6 (n−6) arachidonic acid (AA). Although the metabolic ...

    • INHIBITING DNA MISMATCH REPAIR IN COLORECTAL CANCER 

      Zhu, Jingyao (2023-05-10)
      Colorectal cancer (CRC) remains one of the most prevalent cancers in the US with a high mortality rate. Locally advanced and metastatic CRC have poor prognosis and only a small subset (5- 15%) of patient tumors with DNA ...

    • Inhibiting Metastatic Breast Cancer Cell Migration via the Synergy of Targeted, pH-triggered siRNA Delivery and Chemokine Axis Blockade 

      Guo, Peng; You, Jin-Oh; Yang, Jiang; Jia, Di; Moses, Marsha A.; Auguste, Debra T. (American Chemical Society, 2014)
      Because breast cancer patient survival inversely correlates with metastasis, we engineered vehicles to inhibit both the C-X-C chemokine receptor type 4 (CXCR4) and lipocalin-2 (Lcn2) mediated migratory pathways. pH-responsive ...

    • Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells 

      Lub, Susanne; Maes, Anke; Maes, Ken; De Veirman, Kim; De Bruyne, Elke; Menu, Eline; Fostier, Karel; Kassambara, Alboukadel; Moreaux, Jérôme; Hose, Dirk; Leleu, Xavier; King, Randall W.; Vanderkerken, Karin; Van Valckenborgh, Els (Impact Journals LLC, 2016)
      The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase involved in cell cycle. During the metaphase-anaphase transition the APC/C is activated by Cdc20. The aim of this study is to elucidate the importance ...

    • Inhibition of Adaptive Immune Responses Leads to a Fatal Clinical Outcome in SIV-Infected Pigtailed Macaques but Not Vervet African Green Monkeys 

      Zahn, Roland C.; Brown, Charles R.; Rett, Melisa D.; Tang, Haili; Pryputniewicz, Sarah; Byrum, Russell A.; Montefiori, David C.; Allan, Jonathan S.; Goldstein, Simoy; Hirsch, Vanessa M.; Schmitz, Joern Engelbert; Li, Ming; Kaur, Amitinder (Public Library of Science, 2009)
      African green monkeys (AGM) and other natural hosts for simian immunodeficiency virus (SIV) do not develop an AIDS-like disease following SIV infection. To evaluate differences in the role of SIV-specific adaptive immune ...

    • Inhibition of AKT with the Orally Active Allosteric AKT Inhibitor, MK-2206, Sensitizes Endometrial Cancer Cells to Progestin 

      Pant, Alok; Lee, Irene I.; Lu, Zhenxiao; Rueda, Bo Ruben; Schink, Julian; Kim, J. Julie (Public Library of Science, 2012)
      Progestin resistance is a major obstacle to treating early stage, well-differentiated endometrial cancer as well as recurrent endometrial cancer. The mechanism behind the suboptimal response to progestin is not well ...

    • Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma 

      Wang, Xiaoen; Solban, Nicolas; Khanna, Prateek; Callea, Marcella; Song, Jiaxi; Alsop, David C.; Pearsall, R. Scott; Atkins, Michael B.; Mier, James W.; Signoretti, Sabina; Alimzhanov, Marat; Kumar, Ravi; Bhasin, Manoj K.; Bhatt, Rupal S. (Impact Journals LLC, 2016)
      Treatment of metastatic renal cell carcinoma (mRCC) with agents that block signaling through vascular endothelial growth factor receptor 2 (VEGFR2) induces disease regression or stabilization in some patients; however, ...

    • Inhibition of Angiogenesis by Tissue Inhibitor of Metalloproteinase-3 

      Olsen, Bjorn; Zetter, Bruce; Apte, S; Murphy, George; Montesano, R; Pepper, M; Voest, E; Anand-Apte, B (Association for Research in Vision and Ophthalmology, 1997-04)
      PURPOSE: It has been established that Sorsby's fundus dystrophy, a dominantly inherited form of blindness, is caused by mutations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) gene. Because choroidal neovascularization ...

    • Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency 

      Malhotra, Rajeev; Burke, Megan F.; Martyn, Trejeeve; Shakartzi, Hannah R.; Thayer, Timothy E.; O’Rourke, Caitlin; Li, Pingcheng; Derwall, Matthias; Spagnolli, Ester; Kolodziej, Starsha A.; Hoeft, Konrad; Mayeur, Claire; Jiramongkolchai, Pawina; Kumar, Ravindra; Buys, Emmanuel S.; Yu, Paul B.; Bloch, Kenneth D.; Bloch, Donald B. (Public Library of Science, 2015)
      Objective: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both ...

    • Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells 

      Orlidge, A.; D'Amore, Patricia Ann (Rockefeller University Press, 1987)
      Morphological studies of developing capillaries and observations of alterations in capillaries associated with pathologic neovascularization indicate that pericytes may act as suppressors of endothelial cell (EC) growth. ...

    • Inhibition of Cdc42 during mitotic exit is required for cytokinesis 

      Atkins, Benjamin D.; Yoshida, Satoshi; Saito, Koji; Wu, Chi-Fang; Lew, Daniel J.; Pellman, David (The Rockefeller University Press, 2013)
      The role of Cdc42 and its regulation during cytokinesis is not well understood. Using biochemical and imaging approaches in budding yeast, we demonstrate that Cdc42 activation peaks during the G1/S transition and during ...

    • Inhibition of Cell Migration by PITENINs: The Role of ARF6 

      Miao, Benchun; Skidan, Igor; Yang, Jinsheng; You, Zerong; Fu, Xueyan; Famulok, Michael; Schaffhausen, Brian; Torchilin, Vladimir; Yuan, Junying; Degterev, Alexei (Nature Publishing Group, 2012)
      We have previously reported the development of small molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activation of Akt, and show ...

    • Inhibition of Cellular Autophagy Deranges Dengue Virion Maturation 

      Mateo, Roberto; Nagamine, Claude M.; Spagnolo, Jeannie; Méndez, Ernesto; Rahe, Michael; Gale, Michael, Jr.; Yuan, Junying; Kirkegaard, Karla (American Society for Microbiology, 2013)
      Autophagy is an important component of the innate immune response, directly destroying many intracellular pathogens. However, some pathogens, including several RNA viruses, subvert the autophagy pathway, or components of ...

    • Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase 1 Protein Expression 

      Barroso, Madalena; Florindo, Cristina; Kalwa, Hermann; Zélia Silva; Turanov, Anton; Carlson, Bradley; de Almeida, Isabel Tavares; Blom, Henk; Gladyshev, Vadim; Hatfield, Dolph; Michel, Thomas; Castro, Rita; Loscalzo, Joseph; Handy, Diane (American Society for Biochemistry and Molecular Biology, 2014)
      Background: Methylation of tRNA(Sec) facilitates the incorporation of selenocysteine at a UGA codon during translation. Results: Accumulation of the homocysteine precursor S-adenosylhomocysteine decreases tRNA(Sec) ...

    • Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6 

      Wu, Geng; He, Xi; Huang, He; Abreu, Jose Garcia (Public Library of Science, 2009)
      The Wnt/β-catenin signaling pathway plays essential roles in cell proliferation and differentiation, and deregulated β-catenin protein levels lead to many types of human cancers. On activation by Wnt, the Wnt co-receptor ...

    • Inhibition of HCV by the serpin antithrombin III 

      Asmal, Mohammed; Seaman, Michael S.; Lin, Wenyu; Chung, Raymond Taeyong; Letvin, Norman L; Geiben-Lynn, Ralf (BioMed Central, 2012)
      Background: Although there have been dramatic strides made recently in the treatment of chronic hepatitis C virus infection, interferon-α based therapy remains challenging for certain populations, including those with ...

    • Inhibition of Hemangiogenesis and LymphangiogenesisafterNormal-Risk Corneal Transplantation by Neutralizing VEGF Promotes Graft Survival 

      Cursiefen, Claus; Cao, Jingtai; Chen, Lu; Liu, Ying; Maruyama, Kazuichi; Jackson, David; Kruse, Friedrich E.; Wiegand, Stanley J.; Dana, Reza; Streilein, J. Wayne (Association for Research in Vision and Ophthalmology (ARVO), 2004)
      purpose. To evaluate the occurrence and time course of hem- and lymphangiogenesis after normal-risk corneal transplantation in the mouse model and to test whether pharmacologic strategies inhibiting both processes improve ...

    • Inhibition of Highly Productive HIV-1 Infection in T Cells, Primary Human Macrophages, Microglia, and Astrocytes by Sargassum fusiforme 

      Paskaleva, Elena E; Lin, Xudong; Cotter, Robin; Klein, Michael T; Roberge, Emily; Yu, Er K; Clark, Bruce; Veille, Jean-Claude; Liu, Yanze; Canki, Mario; Lee, David Marvin; Li, Wen (BioMed Central, 2006)
      Background: The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown ...