Browsing Harvard Medical School by Title
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Inhibition of Cdc42 during mitotic exit is required for cytokinesis
(The Rockefeller University Press, 2013)The role of Cdc42 and its regulation during cytokinesis is not well understood. Using biochemical and imaging approaches in budding yeast, we demonstrate that Cdc42 activation peaks during the G1/S transition and during ... -
Inhibition of Cell Migration by PITENINs: The Role of ARF6
(Nature Publishing Group, 2012)We have previously reported the development of small molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activation of Akt, and show ... -
Inhibition of Cellular Autophagy Deranges Dengue Virion Maturation
(American Society for Microbiology, 2013)Autophagy is an important component of the innate immune response, directly destroying many intracellular pathogens. However, some pathogens, including several RNA viruses, subvert the autophagy pathway, or components of ... -
Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase 1 Protein Expression
(American Society for Biochemistry and Molecular Biology, 2014)Background: Methylation of tRNA(Sec) facilitates the incorporation of selenocysteine at a UGA codon during translation. Results: Accumulation of the homocysteine precursor S-adenosylhomocysteine decreases tRNA(Sec) ... -
Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6
(Public Library of Science, 2009)The Wnt/β-catenin signaling pathway plays essential roles in cell proliferation and differentiation, and deregulated β-catenin protein levels lead to many types of human cancers. On activation by Wnt, the Wnt co-receptor ... -
Inhibition of HCV by the serpin antithrombin III
(BioMed Central, 2012)Background: Although there have been dramatic strides made recently in the treatment of chronic hepatitis C virus infection, interferon-α based therapy remains challenging for certain populations, including those with ... -
Inhibition of Hemangiogenesis and LymphangiogenesisafterNormal-Risk Corneal Transplantation by Neutralizing VEGF Promotes Graft Survival
(Association for Research in Vision and Ophthalmology (ARVO), 2004)purpose. To evaluate the occurrence and time course of hem- and lymphangiogenesis after normal-risk corneal transplantation in the mouse model and to test whether pharmacologic strategies inhibiting both processes improve ... -
Inhibition of Highly Productive HIV-1 Infection in T Cells, Primary Human Macrophages, Microglia, and Astrocytes by Sargassum fusiforme
(BioMed Central, 2006)Background: The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown ... -
Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells
(Public Library of Science, 2016)Protein kinase inhibitors can be used as tools to identify proteins and pathways required for virus replication. Using virus replication assays and western blotting we found that the widely used protein kinase inhibitor ... -
Inhibition of Immune Checkpoints and Vascular Endothelial Growth Factor as Combination Therapy for Metastatic Melanoma: An Overview of Rationale, Preclinical Evidence, and Initial Clinical Data
(Frontiers Media S.A., 2015)The role of angiogenesis as a mediator of immune regulation in the tumor microenvironment has recently come into focus. Furthermore, emerging evidence indicates that immunotherapy can lead to immune-mediated vasculopathy ... -
Inhibition of Inflammatory Arthritis Using Fullerene Nanomaterials
(Public Library of Science, 2015)Inflammatory arthritis (e.g. rheumatoid arthritis; RA) is a complex disease driven by the interplay of multiple cellular lineages. Fullerene derivatives have previously been shown to have anti-inflammatory capabilities ... -
Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9
(Nature Publishing Group, 2016)Progressive multifocal leukoencephalopathy (PML) is a debilitating disease resulting from infection of oligodendrocytes by the JC polyomavirus (JCPyV). Currently, there is no anti-viral therapeutic available against JCPyV ... -
Inhibition of KIT-Glycosylation by 2-Deoxyglucose Abrogates KIT-Signaling and Combination with ABT-263 Synergistically Induces Apoptosis in Gastrointestinal Stromal Tumor
(Public Library of Science, 2015)Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) is frequently used for visualizing gastrointestinal stromal tumors (GIST), which are highly glucose-avid tumors. Dramatic metabolic responses following ... -
Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver
(Nature Publishing Group, 2015)MicroRNAs (miRNAs) are important regulators and potential therapeutic targets of metabolic disease. In this study we show by in vivo administration of locked nucleic acid (LNA) inhibitors that suppression of endogenous ... -
Inhibition of Non-Homologous End Joining Repair Impairs Pancreatic Cancer Growth and Enhances Radiation Response
(Public Library of Science, 2012)Pancreatic ductal adenocarcinoma (PDAC) is amongst the deadliest of human cancers, due to its late diagnosis as well as its intense resistance to currently available therapeutics. To identify mechanisms as to why PDAC are ... -
Inhibition of Notch Signaling in Combination with Paclitaxel Reduces Platinum-Resistant Ovarian Tumor Growth
(Frontiers Media S.A., 2014)Introduction: Ovarian cancer (OvCa) is the most lethal gynecologic malignancy in the United States because of chemoresistant recurrent disease. Our objective was to investigate the efficacy of inhibiting the Notch pathway ... -
Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism
(Impact Journals LLC, 2016)Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits ... -
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation
(2015)PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases, through clinical genetics and gene disruption in mice. Novel, selective PAD4 inhibitors binding to a calcium-deficient ... -
Inhibition of Patterned Cell Shape Change and Cell Invasion by Discs Large During Drosophila Oogenesis
(Cold Spring Harbor Laboratory, 1997-10-01)Drosophila Discs large (Dlg) is a tumor suppressor gene whose loss in epithelial tissues causes disrupted cell polarity and increased cell proliferation. A human Dlg homolog, hDlg, has been implicated in tumorigenic processes ... -
Inhibition of PKC by Oral Administration of Ruboxistaurin Is Well Tolerated and Ameliorates Diabetes-Induced Retinal Hemodynamic Abnormalities in Patients
(Association for Research in Vision and Ophthalmology (ARVO), 2006)Purpose. To assess ocular and systemic safety and pharmacodynamic effects of the oral PKC β selective inhibitor ruboxistaurin (RBX; LY333531) mesylate in patients with diabetes. Methods. This was a double-masked, ...