Browsing Harvard Medical School by Title
Now showing items 9159-9178 of 18428
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Inhibitory Effects of Resveratrol on PDGF-BB-Induced Retinal Pigment Epithelial Cell Migration via PDGFRβ, PI3K/Akt and MAPK Pathways
(Public Library of Science, 2013)Purpose: In diseases such as proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy, and age-related macular degeneration, retinal pigment epithelial (RPE) cells proliferate and migrate. Moreover, ... -
Inhibitory receptor expression on memory CD8 T cells following Ad vector immunization
(Elsevier Science, 2016)T cells are an important component of immune responses, and their function is influenced by their expression of inhibitory receptors. Immunization with alternative serotype adenovirus (Ad) vectors induces highly functional ... -
Initial Development and Validation of a Patient-Reported Symptom Survey for Small-Fiber Polyneuropathy
(Elsevier BV, 2017)Small-fiber polyneuropathy (SFPN) affects unmyelinated and thinly myelinated peripheral axons. Several questionnaires have been developed to assess polyneuropathy from diabetes or chemotherapy, but none for SFPN from other ... -
Initial transcribed region sequences influence the composition and functional properties of the bacterial elongation complex
(Cold Spring Harbor Laboratory Press, 2011)The bacterial RNA polymerase (RNAP) holoenzyme consists of a catalytic core enzyme (alpha 2 beta beta'omega) in complex with a sigma factor that is essential for promoter recognition and transcription initiation. During ... -
Initiating oncogenic event determines gene-expression patterns of human breast cancer models
(National Academy of Sciences, 2002)Molecular expression profiling of tumors initiated by transgenic overexpression of c-myc, c-neu, c-ha-ras, polyoma middle T antigen (PyMT) or simian virus 40 T/t antigen (T-ag) targeted to the mouse mammary gland have ... -
Injectable Graphene Oxide/Hydrogel-Based Angiogenic Gene Delivery System for Vasculogenesis and Cardiac Repair
(American Chemical Society, 2014)The objective of this study was to develop an injectable and biocompatible hydrogel which can efficiently deliver a nanocomplex of graphene oxide (GO) and vascular endothelial growth factor-165 (VEGF) pro-angiogenic gene ... -
Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction
(John Wiley and Sons Inc., 2015)Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, ... -
Injectable, spontaneously assembling inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy
(2015)Materials implanted in the body to program host immune cells are a promising alternative to transplantation of ex vivo–manipulated cells to direct an immune response, but required a surgical procedure. Here we demonstrate ... -
Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
(MyJove Corporation, 2016)Approximately 90% of human cancer deaths are linked to metastasis. Despite the prevalence and relative harm of metastasis, therapeutics for treatment or prevention are lacking. We report a method for the establishment of ... -
iNKT Cell Production of GM-CSF Controls Mycobacterium tuberculosis
(Public Library of Science, 2014)Invariant natural killer T (iNKT) cells are activated during infection, but how they limit microbial growth is unknown in most cases. We investigated how iNKT cells suppress intracellular Mycobacterium tuberculosis (Mtb) ... -
Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation
(Nature Publishing Group, 2012)Background:: Tracheal aspirates (TAs) from critically ill neonates accumulate bacterial endotoxin and demonstrate mobilization of endotoxin-binding proteins, but the potential bioactivity of endotoxin in TAs is unknown. ... -
Innate Immune Adaptor MyD88 Mediates Neutrophil Recruitment and Myocardial Injury after Ischemia-Reperfusion in Mice
(American Physiological Society, 2008)MyD88 is an adaptor protein critical for innate immune response against microbial infection and in certain noninfectious tissue injury. The present study examined the role of MyD88 in myocardial inflammation and injury ... -
Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines
(2014)Unique features of immunity early in life include a distinct immune system particularly reliant on innate immunity, with weak T helper (Th)1-polarizing immune responses, and impaired responses to certain vaccines leading ... -
Innate Immune Reconstitution in the Humanized Bone Marrow-Liver-Thymus (HuBLT) Mouse Model Is Essential for Adaptive Immune Responses to HIV-1 Infection and Can Be Enhanced via AAV-Mediated Human Cytokine Delivery
(2018-05-15)BACKGROUND: Mice harboring a human immune system (a.k.a. “humanized” mice) are a revolutionary small-animal model consisting of a human-to-mouse hematopoietic xenograft that allows for the scientific and clinical study of ... -
Innate Immunity and Resistance to Tolerogenesis in Allotransplantation
(Frontiers Research Foundation, 2012)The development of immunosuppressive drugs to control adaptive immune responses has led to the success of transplantation as a therapy for end-stage organ failure. However, these agents are largely ineffective in suppressing ... -
Innate immunity is a key factor for the resolution of inflammation in asthma
(2015)The resolution of inflammation is an integral and natural part of the physiological response to tissue injury, infection and allergens or other noxious stimuli. Resolution is now recognised as an active process with highly ... -
Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1
(2014)Apolipoprotein L1 (APOL1) risk variants greatly elevate the risk of kidney disease in African Americans. Here we report a cohort of patients who developed collapsing focal segmental glomerulosclerosis while receiving ... -
Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating TH1 Adaptive Immunity
(American Heart Association, 2014)Background: Atherosclerotic lesions grow via the accumulation of leukocytes and oxidized lipoproteins in the vessel wall. Leukocytes can attenuate or augment atherosclerosis through the release of cytokines, chemokines, ... -
Innate Response Activator B Cells Protect Against Microbial Sepsis
(American Association for the Advancement of Science, 2012)Recognition and clearance of a bacterial infection are fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B ... -
The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics
(The Rockefeller University Press, 2013)Cyclic AMP (cAMP)-dependent phosphorylation has been reported to exert biological effects in both the mitochondrial matrix and outer mitochondrial membrane (OMM). However, the kinetics, targets, and effectors of the cAMP ...