Browsing Harvard Medical School by Title
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Intermediate filaments enable pathogen docking to trigger type 3 effector translocation
(2016)Type 3 secretion systems (T3SSs) of bacterial pathogens translocate bacterial effector proteins that mediate disease into the eukaryotic cytosol. Effectors traverse the plasma membrane through a translocon pore formed by ... -
Intermediate Phenotypes Identify Divergent Pathways to Alzheimer's Disease
(Public Library of Science, 2010)Background: Recent genetic studies have identified a growing number of loci with suggestive evidence of association with susceptibility to Alzheimer's disease (AD). However, little is known of the role of these candidate ... -
The “Intermediate” CD14++CD16+ monocyte subset increases in severe peripheral artery disease in humans
(Nature Publishing Group, 2016)Monocytes are key players in atherosclerotic. Human monocytes display a considerable heterogeneity and at least three subsets can be distinguished. While the role of monocyte subset heterogeneity has already been well ... -
Intermittent high-dose treatment with erlotinib enhances therapeutic efficacy in EGFR-mutant lung cancer
(Impact Journals LLC, 2015)Treatment with EGFR kinase inhibitors improves progression-free survival of patients with EGFR-mutant lung cancer. However, all patients with initial response will eventually acquire resistance and die from tumor recurrence. ... -
An Intermittent Live Cell Imaging Screen for siRNA Enhancers and Suppressors of a Kinesin-5 Inhibitor
(Public Library of Science, 2009)Kinesin-5 (also known as Eg5, KSP and Kif11) is required for assembly of a bipolar mitotic spindle. Small molecule inhibitors of Kinesin-5, developed as potential anti-cancer drugs, arrest cell in mitosis and promote ... -
Intermolecular Phosphorylation between Insulin Holoreceptors Does Not Stimulate Substrate Kinase Activity
(American Society for Biochemistry and Molecular Biology, 1995) -
The Internal Architecture of Leukocyte Lipid Body Organelles Captured by Three-Dimensional Electron Microscopy Tomography
(Public Library of Science, 2013)Lipid bodies (LBs), also known as lipid droplets, are complex organelles of all eukaryotic cells linked to a variety of biological functions as well as to the development of human diseases. In cells from the immune system, ... -
The Internal Circadian Clock Increases Hunger and Appetite in the Evening Independent of Food Intake and Other Behaviors
(2013)Objective: Despite the extended overnight fast, paradoxically, people are typically not ravenous in the morning and breakfast is typically the smallest meal of the day. Here we assessed whether this paradox could be explained ... -
An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2
(The Rockefeller University Press, 2013)How is massive conformational change in integrins achieved on a rapid timescale? We report crystal structures of a metastable, putative transition state of integrin αXβ2. The αXβ2 ectodomain is bent; however, a lattice ... -
The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1
(Public Library of Science, 2008)Background: Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims N-terminally extended antigenic peptide precursors down to mature antigenic peptides for presentation by major histocompatibility complex (MHC) class I ... -
Internal State Dynamics Shape Brainwide Activity and Foraging Behaviour
(Springer Science and Business Media LLC, 2019-12-18)The brain has persistent internal states that can modulate every aspect of an animal’s mental experience(1–4). In complex tasks such as foraging, internal state is dynamic(5–8). C. elegans alternate between local search ... -
Internalization of Staphylococcus aureus by Human Corneal Epithelial Cells: Role of Bacterial Fibronectin-Binding Protein and Host Cell Factors
(American Society for Microbiology, 2002)Wild-type Staphylococcus aureus was observed to be capable of invading human corneal epithelial cells (HCEC) in vitro. Internalization of S. aureus required expression of fibronectin-binding proteins (FnBPs); the capacity ... -
Internally Generated Preactivation of Single Neurons in Human Medial Frontal Cortex Predicts Volition
(Elsevier BV, 2011)Understanding how self-initiated behavior is encoded by neuronal circuits in the human brain remains elusive. We recorded the activity of 1019 neurons while twelve subjects performed self-initiated finger movement. We ... -
The International Cancer Expert Corps: A Unique Approach for Sustainable Cancer Care in Low and Lower-Middle Income Countries
(Frontiers Media S.A., 2014)The growing burden of non-communicable diseases including cancer in low- and lower-middle income countries (LMICs) and in geographic-access limited settings within resource-rich countries requires effective and sustainable ... -
The International Charter for Human Values in Healthcare: An interprofessional global collaboration to enhance values and communication in healthcare
(Elsevier BV, 2014)Objectives: The human dimensions of healthcare—core values and skilled communication necessary for every healthcare interaction—are fundamental to compassionate, ethical, and safe relationship-centered care. The objectives ... -
International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD (Part I)
(Nature Publishing Group, 2013)The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose ... -
International Collaboration for the Epidemiology of eGFR in Low and Middle Income Populations - Rationale and core protocol for the Disadvantaged Populations eGFR Epidemiology Study (DEGREE)
(BioMed Central, 2017)Background: There is an increasing recognition of epidemics of primarily tubular-interstitial chronic kidney disease (CKD) clustering in agricultural communities in low- and middle-income countries (LMICs). Although it is ... -
An International Comparative Public Health Analysis of Sex Trafficking of Women and Girls in Eight Cities: Achieving a More Effective Health Sector Response
(Springer US, 2013)Sex trafficking, trafficking for the purpose of forced sexual exploitation, is a widespread form of human trafficking that occurs in all regions of the world, affects mostly women and girls, and has far-reaching health ... -
International consensus guidance for management of myasthenia gravis: Executive summary
(Lippincott Williams & Wilkins, 2016)Objective: To develop formal consensus-based guidance for the management of myasthenia gravis (MG). Methods: In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance ... -
International consensus on (ICON) anaphylaxis
(World Allergy Organization, 2014)ICON: Anaphylaxis provides a unique perspective on the principal evidence-based anaphylaxis guidelines developed and published independently from 2010 through 2014 by four allergy/immunology organizations. These guidelines ...