Browsing Harvard Medical School by Title
Now showing items 9559-9578 of 18428
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IRE1α Activation Protects Mice Against Acetaminophen-Induced Hepatotoxicity
(The Rockefeller University Press, 2012)Mice lacking the transcription factor XBP1 exhibit constitutive activation of the stress sensor IRE1α and are protected from acetaminophen overdose–induced acute liver failure. -
IRF3 and type I interferons fuel a fatal response to myocardial infarction
(Springer Nature, 2017)Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against infections and cancer, but excessive IRF3 activation and type I IFN production cause autoinflammatory conditions such as Aicardi–Goutières ... -
Irisin and the therapeutic benefits of exercise
(BioMed Central, 2012) -
Irisin Levels Are Lower in Young Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletes and Are Associated with Bone Density and Strength Estimates
(Public Library of Science, 2014)Irisin and FGF21 are novel hormones implicated in the “browning” of white fat, thermogenesis, and energy homeostasis. However, there are no data regarding these hormones in amenorrheic athletes (AA) (a chronic energy deficit ... -
Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval
(National Institute of Environmental Health Sciences, 2008)Background: Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance ... -
Iron Metabolism, Incident Heart Failure Phenotypes and Cardiac Dysfunction in Late Life
(2023-05-11)Iron contributes to a variety of biological processes, such as oxygen transport, mitochondrial respiration, and free radical protection with particular importance in cells with high energy requirements, such as cardiomyocytes. ... -
Iron Replacement in Patients with Inflammatory Bowel Disease – A Systematic Review and Meta-Analysis
(Oxford University Press (OUP), 2015-08)Background A number of controlled trials and prospective studies have compared intravenous (IV) to oral (PO) iron for the treatment of IDA, with mixed results. Methods We conducted a systematic review of trials ... -
Iron Status Predicts Treatment Failure and Mortality in Tuberculosis Patients: A Prospective Cohort Study from Dar es Salaam, Tanzania
(Public Library of Science, 2012)Background: Experimental data suggest a role for iron in the course of tuberculosis (TB) infection, but there is limited evidence on the potential effects of iron deficiency or iron overload on the progression of TB disease ... -
IRS-2 Deficiency Impairs NMDA Receptor-Dependent Long-term Potentiation
(Oxford University Press, 2011)The beneficial effects of insulin and insulin-like growth factor I on cognition have been documented in humans and animal models. Conversely, obesity, hyperinsulinemia, and diabetes increase the risk for neurodegenerative ... -
IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation
(Nature Publishing Group, 2016)Endoplasmic reticulum (ER) stress is among several pathological features that underlie β-cell failure in the development of type 1 and type 2 diabetes. Adaptor proteins in the insulin/insulin-like-growth factor-1 signaling ... -
IRS1 Genotype Modulates Metabolic Syndrome Reversion in Response to 2-Year Weight-Loss Diet Intervention: The POUNDS LOST trial
(American Diabetes Association, 2013)OBJECTIVE Genetic variants near IRS1 are associated with features of the metabolic syndrome (MetS). We examined whether genetic variants near IRS1 might modulate the effects of diets varying in fat content on the MetS ... -
Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis★
(Elsevier, 2013)Insulin receptor substrates (Irs1, 2, 3 and Irs4) mediate the actions of insulin/IGF1 signaling. They have similar structure, but distinctly regulate development, growth, and metabolic homeostasis. Irs2 contributes to ... -
IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer
(Blackwell Publishing Ltd, 2013)Copy number alterations are frequently found in colorectal cancer (CRC), and recurrent gains or losses are likely to correspond to regions harbouring genes that promote or impede carcinogenesis respectively. Gain of ... -
Is aggressive treatment of smoldering myeloma the path to curing myeloma?
(American Society of Hematology, 2023-07-27)Smoldering multiple myeloma (SMM) is an asymptomatic condition that precedes newly diagnosed multiple myeloma (ND MM) and is present in ~1 of 200 individuals (0.5%) aged >40 years.1 The optimal management of patients with ... -
Is Childhood Pneumonia Associated With Future Disease Susceptibility? An Investigation Into the Early Origins of Chronic Obstructive Pulmonary Disease
(2015-09-29)BACKGROUND Development of adult respiratory disease is influenced by events in childhood. The impact of childhood pneumonia on chronic obstructive pulmonary disease (COPD) is not well defined. We hypothesize that childhood ... -
Is COPD a Progressive Disease? A Long Term Bode Cohort Observation
(Public Library of Science, 2016)Background: The Global Initiative for Obstructive Lung Diseases (GOLD) defines COPD as a disease that is usually progressive. GOLD also provides a spirometric classification of airflow limitation. However, little is known ... -
Is DNA methylation of tumour suppressor genes epigenetic?
(eLife Sciences Publications, Ltd, 2014)In colorectal cancer cells, a non-epigenetic transcriptional pathway that is mediated by an oncogene maintains DNA methylation of tumour suppressor genes -
Is Food Insecurity Associated with HIV Risk? Cross-Sectional Evidence from Sexually Active Women in Brazil
(Public Library of Science, 2012)Background: Understanding how food insecurity among women gives rise to differential patterning in HIV risks is critical for policy and programming in resource-limited settings. This is particularly the case in Brazil, ... -
Is Freezing of Gait in Parkinson's Disease a Result of Multiple Gait Impairments? Implications for Treatment
(Hindawi Publishing Corporation, 2012)Several gait impairments have been associated with freezing of gait (FOG) in patients with Parkinson's disease (PD). These include deteriorations in rhythm control, gait symmetry, bilateral coordination of gait, dynamic ... -
Is Household Air Pollution a Risk Factor for Eye Disease?
(MDPI, 2013)In developing countries, household air pollution (HAP) resulting from the inefficient burning of coal and biomass (wood, charcoal, animal dung and crop residues) for cooking and heating has been linked to a number of ...