Browsing Harvard Medical School by Title

Now showing items 9738-9757 of 18428

    • Lactadherin Inhibits Secretory Phospholipase A2 Activity on Pre-Apoptotic Leukemia Cells 

      Nyegaard, Steffen; Novakovic, Valerie A.; Rasmussen, Jan T.; Gilbert, Gary E. (Public Library of Science, 2013)
      Secretory phospholipase A2 (sPLA2) is a critical component of insect and snake venoms and is secreted by mammalian leukocytes during inflammation. Elevated secretory PLA2 concentrations are associated with autoimmune ...

    • Lactate, a Neglected Factor for Diabetes and Cancer Interaction 

      Wu, Yong; Dong, Yunzhou; Atefi, Mohammad; Liu, Yanjun; Elshimali, Yahya; Vadgama, Jaydutt V. (Hindawi Publishing Corporation, 2016)
      Increasing body of evidence suggests that there exists a connection between diabetes and cancer. Nevertheless, to date, the potential reasons for this association are still poorly understood and currently there is no ...

    • Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation 

      Okubo, Koshu; Kamiya, Mako; Urano, Yasuteru; Nishi, Hiroshi; Herter, Jan M.; Mayadas, Tanya; Hirohama, Daigoro; Suzuki, Kazuo; Kawakami, Hiroshi; Tanaka, Mototsugu; Kurosawa, Miho; Kagaya, Shinji; Hishikawa, Keiichi; Nangaku, Masaomi; Fujita, Toshiro; Hayashi, Matsuhiko; Hirahashi, Junichi (Elsevier, 2016)
      Neutrophils are central players in the innate immune system. They generate neutrophil extracellular traps (NETs), which protect against invading pathogens but are also associated with the development of autoimmune and/or ...

    • Lacunar Infarction and Small Vessel Disease: Pathology and Pathophysiology 

      Caplan, Louis R (Korean Stroke Society, 2015)
      Two major vascular pathologies underlie brain damage in patients with disease of small size penetrating brain arteries and arterioles; 1) thickening of the arterial media and 2) obstruction of the origins of penetrating ...

    • Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development 

      Razafsky, David; Ward, Candace; Potter, Chloe; Zhu, Wanqiu; Xue, Yunlu; Kefalov, Vladimir J.; Fong, Loren G.; Young, Stephen G.; Hodzic, Didier (The American Society for Cell Biology, 2016)
      Lamin B1 and lamin B2 are essential building blocks of the nuclear lamina, a filamentous meshwork lining the nucleoplasmic side of the inner nuclear membrane. Deficiencies in lamin B1 and lamin B2 impair neurodevelopment, ...

    • Land use regression modeling of intra-urban residential variability in multiple traffic-related air pollutants 

      Clougherty, Jane E; Wright, Rosalind Jo; Baxter, Lisa K; Levy, Jonathan Ian (BioMed Central, 2008)
      Background: There is a growing body of literature linking GIS-based measures of traffic density to asthma and other respiratory outcomes. However, no consensus exists on which traffic indicators best capture variability ...

    • The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis 

      Ben-David, Uri; Ha, Gavin; Khadka, Prasidda; Jin, Xin; Wong, Bang; Franke, Lude; Golub, Todd R. (Nature Publishing Group, 2016)
      Aneuploidy and copy-number alterations (CNAs) are a hallmark of human cancer. Although genetically engineered mouse models (GEMMs) are commonly used to model human cancer, their chromosomal landscapes remain underexplored. ...

    • The Landscape of Inappropriate Laboratory Testing: A 15-Year Meta-Analysis 

      Zhi, Ming; Ding, Eric L.; Theisen-Toupal, Jesse; Whelan, Julia; Arnaout, Ramy (Public Library of Science, 2013)
      Background: Laboratory testing is the single highest-volume medical activity and drives clinical decision-making across medicine. However, the overall landscape of inappropriate testing, which is thought to be dominated ...

    • The landscape of metastatic progression patterns across major human cancers 

      Budczies, Jan; von Winterfeld, Moritz; Klauschen, Frederick; Bockmayr, Michael; Lennerz, Jochen K.; Denkert, Carsten; Wolf, Thomas; Warth, Arne; Dietel, Manfred; Anagnostopoulos, Ioannis; Weichert, Wilko; Wittschieber, Daniel; Stenzinger, Albrecht (Impact Journals LLC, 2015)
      The majority of patients with solid malignancies die from metastatic burden. However, our current understanding of the mechanisms and resulting patterns of dissemination is limited. Here, we analyzed patterns of metastatic ...

    • The landscape of Neandertal ancestry in present-day humans 

      Sankararaman, Sriram; Mallick, Swapan; Dannemann, Michael; Prüfer, Kay; Kelso, Janet; Pääbo, Svante; Patterson, Nick; Reich, David (2014)
      Analyses of Neandertal genomes have revealed that Neandertals have contributed genetic variants to modern humans1–2. The antiquity of Neandertal gene flow into modern humans means that regions that derive from Neandertals ...

    • A Landscape of Pharmacogenomic Interactions in Cancer 

      Iorio, Francesco; Knijnenburg, Theo A.; Vis, Daniel J.; Bignell, Graham R.; Menden, Michael P.; Schubert, Michael; Aben, Nanne; Gonçalves, Emanuel; Barthorpe, Syd; Lightfoot, Howard; Cokelaer, Thomas; Greninger, Patricia; van Dyk, Ewald; Chang, Han; de Silva, Heshani; Heyn, Holger; Deng, Xianming; Egan, Regina K.; Liu, Qingsong; Mironenko, Tatiana; Mitropoulos, Xeni; Richardson, Laura; Wang, Jinhua; Zhang, Tinghu; Moran, Sebastian; Sayols, Sergi; Soleimani, Maryam; Tamborero, David; Lopez-Bigas, Nuria; Ross-Macdonald, Petra; Esteller, Manel; Gray, Nathanael S.; Haber, Daniel A.; Stratton, Michael R.; Benes, Cyril H.; Wessels, Lodewyk F.A.; Saez-Rodriguez, Julio; McDermott, Ultan; Garnett, Mathew J. (Cell Press, 2016)
      Summary Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies in the clinic is challenging. ...

    • The landscape of RNA Pol II binding reveals a stepwise transition during ZGA 

      Liu, Bofeng; Xu, Qianhua; Wang, Qiujun; Feng, Su; Lai, Fangnong; Wang, Peizhe; Zheng, Fangyuan; Xiang, Yunlong; Wu, Jingyi; Nie, Junwei; Qiu, Cui; Xia, Weikun; Li, Lijia; Yu, Guang; Lin, Zili; Xu, Kai; Xiong, Zhuqing; Kong, Feng; Liu, Ling; Huang, Chunyi; Yu, Yang; Na, Jie; Xie, Wei (Springer Science and Business Media LLC, 2020-10-28)

    • The Landscape of Structural Variants Within Pediatric High Grade Glioma 

      Zack, Travis (2018-05-15)
      Pediatric high grade glioma is class of aggressive pediatric brain tumors with no current effective means of treatment. Unlike other pediatric tumors that often are characterized by specific, high frequency driver alterations ...

    • Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment 

      Friedman, Adam A.; Amzallag, Arnaud; Pruteanu-Malinici, Iulian; Baniya, Subash; Cooper, Zachary A.; Piris, Adriano; Hargreaves, Leeza; Igras, Vivien; Frederick, Dennie T.; Lawrence, Donald P.; Haber, Daniel A.; Flaherty, Keith T.; Wargo, Jennifer A.; Ramaswamy, Sridhar; Benes, Cyril H.; Fisher, David E. (Public Library of Science, 2015)
      A newer generation of anti-cancer drugs targeting underlying somatic genetic driver events have resulted in high single-agent or single-pathway response rates in selected patients, but few patients achieve complete responses ...

    • The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets 

      Chong, Dawn Q.; Zhu, Andrew X. (Impact Journals LLC, 2016)
      Cholangiocarcinoma (CCA) is a relatively rare malignancy that arises from the epithelial cells of the intrahepatic, perihilar and distal biliary tree. Intrahepatic CCA (ICC) represents the second most common primary liver ...

    • Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization 

      Sarraf, Shireen A.; Raman, Malavika; Guarani-Pereira, Virginia; Sowa, Mathew E.; Huttlin, Edward L.; Gygi, Steven P.; Harper, J. Wade (2013)
      The PARKIN (PARK2) ubiquitin ligase and its regulatory kinase PINK1 (PARK6), often mutated in familial early onset Parkinson’s Disease (PD), play central roles in mitochondrial homeostasis and mitophagy.1–3 While PARKIN ...

    • The Langerhans cell histiocytosis: a disease in search of an identity 

      Rodriguez-Galindo, Carlos (Associação Brasileira de Hematologia e Hemoterapia, 2011)

    • Langerin+ Dermal DC, but not Langerhans cells, are required for effective CD8 mediated immune responses after skin scarification with Vaccinia Virus (VACV) 

      Seneschal, Julien; Jiang, Xiaodong; Kupper, Thomas S. (2013)
      Skin scarification (s.s.) with Vaccinia virus (VACV) is essential for generation of an optimal protective T cell memory immune response. Dendritic Cells (DC), which are professional antigen presenting cells, are required ...

    • Language and Traits of Autism Spectrum Conditions: Evidence of Limited Phenotypic and Etiological Overlap 

      Taylor, Mark J.; Charman, Tony; Robinson, Elise B.; Hayiou-Thomas, Marianna E.; Happé, Francesca; Dale, Philip S.; Ronald, Angelica (2015)
      Language difficulties have historically been viewed as integral to autism spectrum conditions (ASC), leading molecular genetic studies to consider whether ASC and language difficulties have overlapping genetic bases. The ...

    • The Language of Delirium: Keywords for Identifying Delirium from Medical Records 

      Puelle, Margaret R.; Kosar, Cyrus M.; Xu, Guoquan; Schmitt, Eva; Jones, Richard N.; Marcantonio, Edward Ralph; Cooper, Zara R; Inouye, Sharon K.; Saczynski, Jane S. (SLACK, Inc., 2015)
      Electronic medical records (EMRs) offer the opportunity to streamline the search for patients with possible delirium. The purpose of the current study was to identify words and phrases commonly noted in charts of patients ...