Browsing Harvard Medical School by Title

Now showing items 9796-9815 of 18428

    • Large-Scale Screening of a Targeted Enterococcus faecalis Mutant Library Identifies Envelope Fitness Factors 

      Rigottier-Gois, Lionel; Alberti, Adriana; Houel, Armel; Taly, Jean-François; Palcy, Philippe; Manson, Janet; Pinto, Daniela; Matos, Renata C.; Carrilero, Laura; Montero, Natalia; Tariq, Muhammad; Karsens, Harma; Repp, Christian; Kropec, Andrea; Budin-Verneuil, Aurélie; Benachour, Abdellah; Sauvageot, Nicolas; Bizzini, Alain; Gilmore, Michael S.; Bessières, Philippe; Kok, Jan; Huebner, Johannes; Lopes, Fatima; Gonzalez-Zorn, Bruno; Hartke, Axel; Serror, Pascale (Public Library of Science (PLoS), 2011)
      Spread of antibiotic resistance among bacteria responsible for nosocomial and community-acquired infections urges for novel therapeutic or prophylactic targets and for innovative pathogen-specific antibacterial compounds. ...

    • Laser Microdissection of the Alveolar Duct Enables Single-Cell Genomic Analysis 

      Bennett, Robert D.; Ysasi, Alexandra B.; Belle, Janeil M.; Wagner, Willi L.; Konerding, Moritz A.; Blainey, Paul C.; Pyne, Saumyadipta; Mentzer, Steven J. (Frontiers Media S.A., 2014)
      Complex tissues such as the lung are composed of structural hierarchies such as alveoli, alveolar ducts, and lobules. Some structural units, such as the alveolar duct, appear to participate in tissue repair as well as the ...

    • Laser microsurgery reveals conserved viscoelastic behavior of the kinetochore 

      Cojoc, Gheorghe; Roscioli, Emanuele; Zhang, Lijuan; García-Ulloa, Alfonso; Shah, Jagesh V.; Berns, Michael W.; Pavin, Nenad; Cimini, Daniela; Tolić, Iva M.; Gregan, Juraj (The Rockefeller University Press, 2016)
      Accurate chromosome segregation depends on proper kinetochore–microtubule attachment. Upon microtubule interaction, kinetochores are subjected to forces generated by the microtubules. In this work, we used laser ablation ...

    • Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds 

      Hajjarian, Zeinab; Nia, Hadi Tavakoli; Ahn, Shawn; Grodzinsky, Alan J.; Jain, Rakesh K.; Nadkarni, Seemantini K. (Nature Publishing Group, 2016)
      Natural and synthetic hydrogel scaffolds exhibit distinct viscoelastic properties at various length scales and deformation rates. Laser Speckle Rheology (LSR) offers a novel, non-contact optical approach for evaluating the ...

    • Laser thermal therapy monitoring using complex differential variance in optical coherence tomography 

      Lo, William C. Y.; Villiger, Martin; Bouma, Brett; Vakoc, Benjamin; Nam, Ahhyun; Uribe-Patarroyo, Nestor (Wiley, 2016-09-14)
      Conventional thermal therapy monitoring techniques based on temperature are often invasive, limited by point sampling, and are indirect measures of tissue injury, while techniques such as magnetic resonance and ultrasound ...

    • Laser-Supported CD133+ Cell Therapy in Patients with Ischemic Cardiomyopathy: Initial Results from a Prospective Phase I Multicenter Trial 

      Assmann, Alexander; Heke, Michael; Kröpil, Patric; Ptok, Lena; Hafner, Dieter; Ohmann, Christian; Martens, Andreas; Karluß, Antje; Emmert, Maximilian Y.; Kutschka, Ingo; Sievers, Hans-Hinrich; Klein, Hans-Michael (Public Library of Science, 2014)
      Objectives: This study evaluates the safety, principal feasibility and restoration potential of laser-supported CD133+ intramyocardial cell transplantation in patients with ischemic cardiomyopathy. Methods: Forty-two ...

    • Lassa Fever in Post-Conflict Sierra Leone 

      Shaffer, Jeffrey G.; Grant, Donald S.; Schieffelin, John S.; Boisen, Matt L.; Goba, Augustine; Hartnett, Jessica N.; Levy, Danielle C.; Yenni, Rachael E.; Moses, Lina M.; Fullah, Mohammed; Momoh, Mambo; Fonnie, Mbalu; Fonnie, Richard; Kanneh, Lansana; Koroma, Veronica J.; Kargbo, Kandeh; Ottomassathien, Darin; Muncy, Ivana J.; Jones, Abigail B.; Illick, Megan M.; Kulakosky, Peter C.; Haislip, Allyson M.; Bishop, Christopher M.; Elliot, Deborah H.; Brown, Bethany L.; Zhu, Hu; Hastie, Kathryn M.; Andersen, Kristian G.; Gire, Stephen K.; Tabrizi, Shervin; Tariyal, Ridhi; Stremlau, Mathew; Matschiner, Alex; Sampey, Darryl B.; Spence, Jennifer S.; Cross, Robert W.; Geisbert, Joan B.; Folarin, Onikepe A.; Happi, Christian T.; Pitts, Kelly R.; Geske, F. Jon; Geisbert, Thomas W.; Saphire, Erica Ollmann; Robinson, James E.; Wilson, Russell B.; Sabeti, Pardis C.; Henderson, Lee A.; Khan, S. Humarr; Bausch, Daniel G.; Branco, Luis M.; Garry, Robert F. (Public Library of Science, 2014)
      Background: Lassa fever (LF), an often-fatal hemorrhagic disease caused by Lassa virus (LASV), is a major public health threat in West Africa. When the violent civil conflict in Sierra Leone (1991 to 2002) ended, an ...

    • Late Na+ current and protracted electrical recovery are critical determinants of the aging myopathy 

      Signore, Sergio; Sorrentino, Andrea; Borghetti, Giulia; Cannata, Antonio; Meo, Marianna; Zhou, Yu; Kannappan, Ramaswamy; Pasqualini, Francesco; O'Malley, Heather; Sundman, Mark; Tsigkas, Nikolaos; Zhang, Eric; Arranto, Christian; Mangiaracina, Chiara; Isobe, Kazuya; Sena, Brena F.; Kim, Junghyun; Goichberg, Polina; Nahrendorf, Matthias; Isom, Lori L.; Leri, Annarosa; Anversa, Piero; Rota, Marcello (Nature Pub. Group, 2015)
      The aging myopathy manifests itself with diastolic dysfunction and preserved ejection fraction. We raised the possibility that, in a mouse model of physiological aging, defects in electromechanical properties of cardiomyocytes ...

    • Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation 

      Cerqueira, Sofia; Tan, Min; Li, Shijun; Juillard, Franceline; McVey, Colin; Kaye, Kenneth; Simas, J. Pedro (American Society for Microbiology, 2016)
      Viruses have evolved mechanisms to hijack components of cellular E3 ubiquitin ligases, thus modulating the ubiquitination pathway. However, the biological relevance of such mechanisms for viral pathogenesis in vivo remains ...

    • Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV☆☆☆★ 

      Sullivan, Zuri A.; Wong, Emily B.; Ndung'u, Thumbi; Kasprowicz, Victoria O.; Bishai, William R. (Elsevier, 2015)
      In recent years, chronic immune activation and systemic inflammation have emerged as hallmarks of HIV disease progression and mortality. Several studies indicate that soluble inflammatory biomarkers (sCD14, IL-6, IL-8, CRP ...

    • Latent Herpes Simplex Virus Infection of Sensory Neurons Alters Neuronal Gene Expression 

      Kramer, Martha F.; Cook, W. James; Roth, Frederick P.; Zhu, Jia; Holman, Holly; Knipe, David M.; Coen, Donald M. (American Society for Microbiology, 2003)
      of expression,The persistence of herpes simplex virus (HSV) and the diseases that it causes in the human population can be attributed to the maintenance of a latent infection within neurons in sensory ganglia. Little is ...

    • The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro 

      Arbuckle, J. H.; Medveczky, M. M.; Luka, J.; Hadley, S. H.; Luegmayr, A.; Ablashi, D.; Lund, T. C.; Tolar, J.; De Meirleir, K.; Montoya, J. G.; Komaroff, Anthony L.; Ambros, P. F.; Medveczky, P. G. (Proceedings of the National Academy of Sciences, 2010)
      Previous research has suggested that human herpesvirus-6 (HHV-6) may integrate into host cell chromosomes and be vertically transmitted in the germ line, but the evidence—primarily fluorescence in situ hybridization (FISH)—is ...

    • Latent Membrane Protein 1 as a Molecular Adjuvant for Single-Cycle Lentiviral Vaccines 

      Gupta, Sachin; Termini, James M; Niu, Liguo; Kanagavelu, Saravana K; Rahmberg, Andrew Richard; Kornbluth, Richard S; Evans, David T.; Stone, Geoffrey W (BioMed Central, 2011)
      Background Molecular adjuvants are a promising method to enhance virus-specific immune responses and protect against HIV-1 infection. Immune activation by ligands for receptors such as CD40 can induce dendritic cell ...

    • A Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells 

      Zheng, Grace X. Y.; Medeiros, Lea A.; Kirak, Oktay; Dennis, Lucas M.; Jaenisch, Rudolf; Burge, Christopher B.; Ravi, Arvind; Calabrese, Joseph Michael; McManus, Michael Louis; Sharp, Phillip A. (Public Library of Science, 2011)
      MicroRNAs (miRNAs) post-transcriptionally regulate the expression of thousands of distinct mRNAs. While some regulatory interactions help to maintain basal cellular functions, others are likely relevant in more specific ...

    • Lateral Femoral Traction Pin Entry: Risk to the Femoral Artery and Other Medial Neurovascular Structures 

      Kwon, John Young-Yul; Johnson, Catherine E; Appleton, Paul Timothy; Rodriguez, Edward Kenneth (BioMed Central, 2010)
      Background: Femoral skeletal traction assists in the reduction and transient stabilization of pelvic, acetabular, hip, and femoral fractures when splinting is ineffective. Traditional teaching has recommended a medial entry ...

    • The Lateral Prefrontal Cortex Mediates the Hyperalgesic Effects of Negative Cognitions in Chronic Pain Patients 

      Loggia, Marco Luciano; Berna, Chantal; Kim, Jieun; Cahalan, Christine M.; Martel, Marc-Olivier; Gollub, Randy Lyanne; Wasan, Ajay D.; Napadow, Vitaly J.; Edwards, Robert R (Elsevier BV, 2015)
      While high levels of negative affect and cognitions have been associated in chronic pain conditions with greater pain sensitivity, the neural mechanisms mediating the hyperalgesic effect of psychological factors in patients ...

    • The lateralization of language comprehension using event-related potentials 

      COLLINS, PAUL F.; TORRES, FERNANDO T; Nelson, Charles A. (Elsevier, 1990)
      Event-Related Potentials were recorded over occipital and parietal scalp from left- and right-handed adults presented with a language and a non-language visual stimulus using a divided field, “oddball” paradigm. The major ...

    • Lateralized P3 deficit in schizotypal personality disorder 

      Niznikiewicz, Margaret A.; Voglmaier, Martina M.; Shenton, Martha Elizabeth; Dickey, Chandlee C.; Seidman, Larry Joel; Teh, EngKeat; Van Rhoads, Richard; McCarley, Robert William (Elsevier BV, 2000)
      Background: Reduced, left-lateralized P3 amplitude has been reported in several studies focusing on electrophysiologic function in schizophrenia. Also, several lines of evidence suggest a similarity between schizophrenia ...

    • Lateralized, nonepileptic convulsions in an adult with cerebral palsy: Case report and review of the literature☆ 

      Gale, Seth; Safar, Laura; Robbins, Jeffrey; Daffner, Kirk (Elsevier, 2014)
      The authors report a case of unilateral functional neurological symptoms (nonepileptic convulsions) in a 38-year-old man with mild, motor-predominant cerebral palsy. His convulsions are all lateralized to the same side as ...

    • Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway 

      You, Y; Wen, R; Pathak, R; Li, A; Li, W; St Clair, D; Hauer-Jensen, M; Zhou, D; Liang, Y (Nature Publishing Group, 2014)
      Leukemia is a leading cause of cancer death. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or ...