Browsing Harvard Medical School by Title
Now showing items 997-1016 of 18427
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Application of Respondent Driven Sampling to Collect Baseline Data on FSWs and MSM for HIV Risk Reduction Interventions in Two Urban Centres in Papua New Guinea
(Kluwer Academic Publishers-Plenum Publishers, 2006)The need to obtain unbiased information among hard–to-reach and hidden populations for behavioural and biological surveillance, epidemiological studies, and intervention program evaluations has led researchers to search ... -
Applications and Limitations of Inflammatory Biomarkers for Studies on Neurocognitive Impairment in HIV Infection
(Springer US, 2013)Despite reduced prevalence of severe forms of HIV-associated neurocognitive disorders (HAND) on current antiretroviral therapy (ART) regimens, milder forms of neurocognitive impairment (NCI) remain prevalent in HIV-infected ... -
Applications of Computational Fluid Dynamics in Cardiovascular Disease
(Tan Tao University, 2022-10-09)Computational fluid dynamics (CFD), alone or coupled with the most advanced imaging tools, allows for the assessment of blood flow patterns in cardiovascular disease to both understand their pathophysiology and anticipate ... -
Applications of High-Throughput RNA Interference Screens to Problems in Cell and Developmental Biology
(Genetics Society of America, 2007)RNA interference (RNAi) in tissue culture cells has emerged as an excellent methodology for identifying gene functions systematically and in an unbiased manner. Here, we describe how RNAi high-throughput screening (HTS) ... -
Applied statistical training to strengthen analysis and health research capacity in Rwanda
(BioMed Central, 2016)Background: To guide efficient investment of limited health resources in sub-Saharan Africa, local researchers need to be involved in, and guide, health system and policy research. While extensive survey and census data ... -
Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression
(Elsevier, 2015)Diffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations of MDD, however, have thwarted ... -
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper
(Co-Action Publishing, 2015)Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different cell types and participate in physiological and pathophysiological processes. EVs mediate intercellular communication as cell-derived ... -
Applying mathematical models to predict resident physician performance and alertness on traditional and novel work schedules
(BioMed Central, 2016)Background: In 2011 the U.S. Accreditation Council for Graduate Medical Education began limiting first year resident physicians (interns) to shifts of ≤16 consecutive hours. Controversy persists regarding the effectiveness ... -
An Approach to Localizing Corneal Pain Representation in Human Primary Somatosensory Cortex
(Public Library of Science, 2012)The cornea has been a focus of animal electrophysiological research for decades, but little is known regarding its cortical representation in the human brain. This study attempts to localize the somatotopic representation ... -
Approaches to ensuring and improving quality in the context of health system strengthening: a cross-site analysis of the five African Health Initiative Partnership programs
(BioMed Central, 2013)Background: Integrated into the work in health systems strengthening (HSS) is a growing focus on the importance of ensuring quality of the services delivered and systems which support them. Understanding how to define and ... -
Approaches to improve the diagnosis and treatment of traumatic neuropathic pain
(2023-05-11)"The most terrible of all tortures which a nerve wound may inflict.” Silas W. Mitchell, a neurologist during the American Civil War, stated in his book Injuries of Nerves and their Consequence. (1) One hundred and fifty ... -
Approaches to Peripheral Nerve Repair: Generations of Biomaterial Conduits Yielding to Replacing Autologous Nerve Grafts in Craniomaxillofacial Surgery
(Hindawi Publishing Corporation, 2016)Peripheral nerve injury is a common clinical entity, which may arise due to traumatic, tumorous, or even iatrogenic injury in craniomaxillofacial surgery. Despite advances in biomaterials and techniques over the past several ... -
Approaches to Recording Drug Allergies in Electronic Health Records: Qualitative Study
(Public Library of Science, 2014)Background: Drug allergy represent an important subset of adverse drug reactions that is worthy of attention because many of these reactions are potentially preventable with use of computerised decision support systems. ... -
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae
(Cold Spring Harbor Laboratory Press, 2007)The availability of an annotated genome sequence for the yeast Saccharomyces cerevisiae has made possible the proteome-scale study of protein function and protein-protein interactions. These studies rely on availability ... -
“Appropriate” diagnostic testing: supporting diagnostics with evidence-based medicine and shared decision making
(BioMed Central, 2014)Background: Evidence-based medicine is an important approach to avoiding care that is unlikely to benefit patients in both the treatment and the diagnostic context. The medical evidence alone may not determine the most ... -
APRIL Signaling via TACI Mediates Immunosuppression by T Regulatory Cells in Multiple Myeloma: Therapeutic Implications
(Springer Science and Business Media LLC, 2019-02-01)We here investigate how APRIL impacts immune regulatory T cells and directly contributes to the immunosuppressive multiple myeloma (MM) bone marrow (BM) microenvironment. First, APRIL receptor TACI expression is significantly ... -
Aptamer-Functionalized Nanoparticles for Medical Applications: Challenges and Opportunities
(American Chemical Society (ACS), 2012-05-10)With advances in aptamer selection technologies and nanomedicine, aptamer-functionalized nanoparticles are being explored as promising platforms for targeted therapeutic and diagnostic applications. In this Perspective, ... -
AQP2 is Necessary for Vasopressin- and Forskolin-Mediated Filamentous Actin Depolymerization in Renal Epithelial Cells
(The Company of Biologists, 2011)Remodeling of the actin cytoskeleton is required for vasopressin (VP)‐induced aquaporin 2 (AQP2) trafficking. Here, we asked whether VP and forskolin (FK)‐mediated F‐actin depolymerization depends on AQP2 expression. Using ... -
An Aquaporin 3-Notch1 Axis in Keratinocyte Differentiation and Inflammation
(Public Library of Science, 2013)Aquaporin 3 (AQP3) is an aquaglyceroporin which transports water, glycerol and small solutes across the plasma membrane. Its functions are not limited to fluid transport but also involve the regulation of cell proliferation, ... -
Aquaporin 4 is a Ubiquitously Expressed Isoform in the Dogfish (Squalus acanthias) Shark
(Frontiers Research Foundation, 2012)The dogfish ortholog of aquaporin 4 (AQP4) was amplified from cDNA using degenerate PCR followed by cloning and sequencing. The complete coding region was then obtained using 5′ and 3′ RACE techniques. Alignment of the ...