Browsing Harvard Medical School by Issue Date
Now showing items 41-60 of 18428
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THE EFFECTS OF A COMBINED FLIPPED CLASSROOM AND SIMULATION-BASED EDUCATION SESSION OF MALE INFANT GENITOURINARY EXAM ON PEDIATRIC RESIDENT AND ATTENDING COMFORT, CONFIDENCE, PERFORMANCE, AND KNOWLEDGE
(2023-07-08)Introduction and Objective: Pediatricians provide initial assessment and referral of boys with undescended testis (UDT) but receive little training in pediatric genitourinary physical exam (GUPE) and may not be familiar ... -
The Impact of a Hybrid Training Program on Point-of-Care Ultrasound (POCUS) Knowledge Acquisition and Skills among non-ultrasound trained Physicians
(2023-07-08)Background Physicians from around the world with a variety of training backgrounds practice medicine in the United Arab Emirates. Most of these physicians have not received formal ultrasound training, a critical skill to ... -
What Motivates Medical Educators? A Qualitative Study
(2023-07-08)Background Medical educators face many challenges, including an absence of defined roles, lack of a standard career path, and limited support in a system that generally prioritizes research and clinical productivity over ... -
Cancer aneuploidies are shaped primarily by effects on tumour fitness
(Springer Science and Business Media LLC, 2023-06-28)Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent alteration in cancer genomes1,2. However, it is still debated whether their prevalence is due to selection or because they are readily generated ... -
Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury
(Springer Science and Business Media LLC, 2023-06-08)The development of physical dependence and addiction disorders due to misuse of opioid analgesics is a major concern with pain therapeutics. In this study, we developed a mouse model of oxycodone exposure to gain insight ... -
The association of cerebrospinal fluid α-synuclein, level of olfactory disability, and enteric nervous system dysfunction with motor disability, cognitive deficits, and anxiety in Parkinson’s Disease
(2023-05-19)Thesis Overview Parkinsons disease (PD) is a complex neurodegenerative disorder with clinical symptoms of motor and non-motor dysfunction (1,2) including pathological findings of α-synuclein (SYN) aggregates within the ... -
Enhancing the Anti-Tumor Activity of Natural Killer (NK) Cells through NK-Biology Tailored Chimeric Antigen Receptors
(2023-05-17)In recent years, chimeric antigen receptor (CAR) T-cell therapy against cancer has shown remarkable efficacy against B-cell malignancies. However, CAR T-cell therapy bears lethal toxicities and requires autologous use, ... -
Adverse Events Associated with Sedative and Anesthetic Drugs in Pediatric Patients
(2023-05-11)OVERVIEW The use of sedatives and anesthetics in pediatric critical care settings and operating rooms is inevitable. Sedation is required in critically ill pediatric patients to aid ventilation and decrease anxiety and ... -
Iron Metabolism, Incident Heart Failure Phenotypes and Cardiac Dysfunction in Late Life
(2023-05-11)Iron contributes to a variety of biological processes, such as oxygen transport, mitochondrial respiration, and free radical protection with particular importance in cells with high energy requirements, such as cardiomyocytes. ... -
Engineered stem cells releasing oncolytic virus and immunomodulators have therapeutic efficacy in brain metastatic tumors
(2023-05-11)Background: Brain metastasis is common among patients with advanced lung cancer and melanoma and is associated with significant morbidity and mortality. Conventional treatments, such as surgery, radiation, and chemotherapy, ... -
PROTEOMICS IN HEART FAILURE: RISK PREDICTION AND BIOMARKER DISCOVERY
(2023-05-11)Heart failure remains an important clinical question despite significant advances in treatment. 1 Healthcare providers can intervene early and personalize treatment plans by predicting a patient's risk of developing heart ... -
Understanding Cardiovascular Risk: Insights from Obesity and Early Menopause
(2023-05-11)Chapter 1: Introduction and Aims Global burden of CVD Cardiovascular disease (CVD) is a major public health issue that demands urgent attention. In the United States, CVD claims the life of one person approximately every ... -
Approaches to improve the diagnosis and treatment of traumatic neuropathic pain
(2023-05-11)"The most terrible of all tortures which a nerve wound may inflict.” Silas W. Mitchell, a neurologist during the American Civil War, stated in his book Injuries of Nerves and their Consequence. (1) One hundred and fifty ... -
The Relationship between Depression, Stress-Related Neurobiology, and Incident Heart Failure: Understanding the Neurobiological Mechanisms Underlying Exercise as a Preventive Measure
(2023-05-11)Background: Numerous evidence underscores the link between high metabolic activity in the brain related to stress (stress-related neural network activity, SNA) and increased risk of cardiovascular disease (CVD) events, ... -
THE IMPACT OF ROBOTIC SURGICAL APPROACH AND PREOPERATIVE COVID-19 DIAGNOSIS ON POST-BARIATRIC-SURGERY COMPLICATIONS
(2023-05-11)Obesity affects more than 40% of adults in the United States and is a significant cause of metabolic disease. Bariatric surgery was one of the most effective means to improve obesity, metabolic disorders, and long-term ... -
Brain lesion and lesion network analyses of anterograde and retrograde amnesia
(2023-05-11)This thesis investigates lesion location and lesion network analyses in anterograde and retrograde amnesia using a systematic review of amnesia case reports and case series in the published peer-reviewed medical literature. ... -
Smoking Status Among Cancer Patients and its Impact on Health-related Quality of Life (HRQoL): A U.S Nationwide Representative Analysis.
(2023-05-11)By 2023, an alarming 1,958,310 new cancer cases will arise across the United States.(1) To put things into perspective, in January 2019, 16.9 million people--roughly 5% of the population--were living with cancer in the ... -
SARS-CoV-2 Vaccine-Induced Immune Responses among Hematopoietic Stem Cell Transplant Recipients
(2023-05-11)ABSTRACT Background Although SARS-CoV-2 vaccination reduces the risk and severity of coronavirus disease 2019 (COVID-19), several variables may impact the humoral response among patients undergoing hematopoietic stem cell ... -
24H FOLLOW-UP CT| METFORMIN PRETREATMENT: TWO REFLECTIONS FROM CLINICAL STROKE PRACTICE
(2023-05-11)Acute ischemic stroke is a serious medical emergency caused by the blockage of blood flow to the brain. With an estimated 15 million new cases each year, it is a leading cause of morbidity and mortality worldwide. The ... -
NEW DISCOVERIES IN THE ASSOCIATIONS OF STATIN MEDICATION EXPOSURE AND LIVER CIRRHOSIS-RELATED SEQUELAE
(2023-05-11)Abstract Background Statin association with decreased hepatocellular carcinoma (HCC) in subjects with liver cirrhosis and diabetes mellitus type 2 (DM2) has been sparsely studied. Numerous other observational studies and ...