Browsing Harvard Medical School by Title
Now showing items 62-81 of 18423
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A 12-Residue-long Polyleucine Tail Is Sufficient to Anchor Synaptobrevin to the Endoplasmic Reticulum Membrane
(American Society for Biochemistry and Molecular Biology, 1996) -
A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice
(National Academy of Sciences, 2005) -
A broad-spectrum antiviral targeting entry of enveloped viruses
(National Academy of Sciences, 2010)We describe an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1. In sharp ... -
A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance
(National Academy of Sciences, 2016)The bacterial cell wall is critical for maintenance of cell shape and survival. Following exposure to antibiotics that target enzymes required for cell wall synthesis, bacteria typically lyse. Although several cell envelope ... -
A Chimeric Protein of Simian Immunodeficiency Virus Envelope Glycoprotein gp140 and Escherichia coli Aspartate Transcarbamoylase
(American Society for Microbiology, 2004)The envelope glycoproteins of the human immunodeficiency virus and the related simian immunodeficiency virus (SIV) mediate viral entry into host cells by fusing viral and target cell membranes. We have reported expression, ... -
A Cholera Toxin B-subunit Variant That Binds Ganglioside G M1 but Fails to Induce Toxicity
(American Society for Biochemistry and Molecular Biology, 2001) -
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
(National Academy of Sciences, 2010)Many proteins that respond to DNA damage are recruited to DNA lesions. We used a proteomics approach that coupled isotopic labeling with chromatin fractionation and mass spectrometry to uncover proteins that associate with ... -
A Clinician-administered Severity Rating Scale for Illness Anxiety: Development, Reliability, and Validity of the H-ybocs-m
(2012)Background Clinician-administered measures to assess severity of illness anxiety and response to treatment are few. The authors evaluated a modified version of the hypochondriasis-Y-BOCS (H-YBOCS-M), a 19-item, semistructured, ... -
A Combined Mastery Learning and Flipped-Classroom Approach: The Effect on Self-Assessment of Leadership Skills
(2022-05-12)Abstract Strong leadership is associated with better performance of individuals, teams, and organizations. This project aimed to determine whether a flipped-classroom and mastery-learning curriculum is associated with ... -
A Comparative Analysis of Incident Reporting Lag Times in Academic Medical Centres in Japan and the USA
(2010)Background Delays in reporting of medical errors may signal deficiencies in the performance of hospital-based incident reporting. We sought to understand the characteristics of hospitals, providers and patient injuries ... -
A Comparison of Heritability Maps of Cortical Surface Area and Thickness and the Influence of Adjustment for Whole Brain Measures: A Magnetic Resonance Imaging Twin Study
(BMC, 2012)Understanding the genetic and environmental contributions to measures of brain structure such as surface area and cortical thickness is important for a better understanding of the nature of brain-behavior relationships and ... -
A Complex of the Bacteriophage T7 Primase-Helicase and DNA Polymerase Directs Primer Utilization
(American Society for Biochemistry and Molecular Biology, 2001) -
A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance
(BMC, 2008)Background: Quantitative polymerase chain reaction (QPCR) is a widely applied analytical method for the accurate determination of transcript abundance. Primers for QPCR have been designed on a genomic scale but non-specific ... -
A Conserved Motif in Region V of the Large Polymerase Proteins of Nonsegmented Negative-Sense RNA Viruses That Is Essential for mRNA Capping
(American Society for Microbiology, 2008)Nonsegmented negative-sense (NNS) RNA viruses cap their mRNA by an unconventional mechanism. Specifically, 5 ' monophosphate mRNA is transferred to GDP derived from GTP through a reaction that involves a covalent intermediate ... -
A Conserved Motif within the Vitamin K-dependent Carboxylase Gene Is Widely Distributed across Animal Phyla
(American Society for Biochemistry and Molecular Biology, 2000) -
A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors
(Company of Biologists, 2015)Sonic hedgehog (Shh) signaling patterns the vertebrate spinal cord by activating a group of transcriptional repressors in distinct neural progenitors of somatic motor neuron and interneuron subtypes. To identify the action ... -
A DNA-binding Gd chelate for the detection of cell death by MRI
(Royal Society of Chemistry, 2009)GadoTO, a MR contrast agent for the detection of cell death, consists of a nucleic acid-binding fluorophore attached to a gadolinium chelate. -
A Domain of the Gene 4 Helicase/Primase of Bacteriophage T7 Required for the Formation of an Active Hexamer
(American Society for Biochemistry and Molecular Biology, 1995) -
A Dominant Negative Mutant of the Kcc1 K-cl Cotransporter. Both N- And C-terminal Cytoplasmic Domains Are Required for K-cl Cotransport Activity
(American Society for Biochemistry and Molecular Biology, 2001) -
A Double, Long Polar Fimbria Mutant of Escherichia coli O157:H7 Expresses Curli and Exhibits Reduced in Vivo Colonization
(American Society for Microbiology, 2012)Escherichia coli O157:H7 causes food and waterborne enteric infections that can result in hemorrhagic colitis and life-threatening hemolytic uremic syndrome. Intimate adherence of the bacteria to intestinal epithelial cells ...