Browsing Harvard Medical School by Title
Now showing items 9623-9642 of 18423
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JAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition
(Landes Bioscience, 2013)A recent article published by Britschgi et al. in Cancer Cell, “JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer,” describes a ... -
Japanese Encephalitis Accompanied by Cerebral Venous Sinus Thrombosis: a Case Report
(BioMed Central, 2012)Background: Cerebral venous sinus thrombosis (CVST) is a relatively rare cerebrovascular condition which accounts for 0.5% of all strokes. Risk of CVST has been documented in patients with numerous conditions including ... -
A Jaw-Dropping Predicament
(Open Science Company, LLC, 2012) -
JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection
(Public Library of Science, 2016)Over half of adults are seropositive for JC polyomavirus (JCV), but rare individuals develop progressive multifocal leukoencephalopathy (PML), a demyelinating JCV infection of the central nervous system. Previously, PML ... -
Je pense donc je fais: transcranial direct current stimulation modulates brain oscillations associated with motor imagery and movement observation
(Frontiers Media S.A., 2013)Motor system neural networks are activated during movement imagery, observation and execution, with a neural signature characterized by suppression of the Mu rhythm. In order to investigate the origin of this neurophysiological ... -
Jetset: Selecting the Optimal Microarray Probe Set to Represent a Gene
(BioMed Central, 2011)Background: Interpretation of gene expression microarrays requires a mapping from probe set to gene. On many Affymetrix gene expression microarrays, a given gene may be detected by multiple probe sets, which may deliver ... -
JNER: A Forum to Discuss How Neuroscience and Biomedical Engineering are Reshaping Physical Medicine & Rehabilitation
(BioMed Central, 2004)Advances in neuroscience and biomedical engineering deeply affect the clinical practice of physical medicine & rehabilitation. New research findings and engineering tools are continuously made available that have the ... -
JNK Activation is Responsible for Mucus Overproduction in Smoke Inhalation Injury
(BioMed Central, 2010)Background: Increased mucus secretion is one of the important characteristics of the response to smoke inhalation injuries. We hypothesized that gel-forming mucins may contribute to the increased mucus production in a smoke ... -
Job Requirements Compared to Medical School Education: Differences between Graduates from Problem-Based Learning and Conventional Curricula
(BioMed Central, 2010)Background: Problem-based Learning (PBL) has been suggested as a key educational method of knowledge acquisition to improve medical education. We sought to evaluate the differences in medical school education between ... -
Job Strain, Job Insecurity, and Incident Cardiovascular Disease in the Women’s Health Study: Results from a 10-Year Prospective Study
(Public Library of Science, 2012)Objectives: Research about work-related stressors and cardiovascular disease (CVD) has produced mixed findings. Moreover, a paucity of data exists regarding the long-term associations between job strain and job insecurity ... -
Joint Coupling of Awake EEG Frequency Activity and MRI Gray Matter Volumes in the Psychosis Dimension: A BSNIP Study
(Frontiers Media S.A., 2015)Background: Many studies have examined either electroencephalogram (EEG) frequency activity or gray matter volumes (GMV) in various psychoses [including schizophrenia (SZ), schizoaffective (SZA), and psychotic bipolar ... -
Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk
(Nature Publishing Group, 2015)Prolonged estrogen exposure is believed to be the major cause of endometrial cancer. As possible markers of estrogen exposure, various menstrual and reproductive features, e.g., ages at menarche and menopause, are found ... -
Joint Effect of Multiple Common SNPs Predicts Melanoma Susceptibility
(Public Library of Science, 2013)Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the ... -
Joint Effects of Colorectal Cancer Susceptibility Loci, Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer
(Public Library of Science, 2014)Background: Genome wide association studies (GWAS) have identified several SNPs associated with colorectal cancer (CRC) susceptibility. Vitamin D is also inversely associated with CRC risk. Methods: We examined main and ... -
Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood
(Public Library of Science, 2016)Marijuana is the most widely used illicit substance in those diagnosed with bipolar I disorder. However, there is conflicting evidence as to whether marijuana may alleviate or exacerbate mood symptomatology. As bipolar ... -
Joint Modeling of Linkage and Association Using Affected Sib-pair Data
(BioMed Central, 2007)There has been a growing interest in developing strategies for identifying single-nucleotide polymorphisms (SNPs) that explain a linkage signal by joint modeling of linkage and association. We compare several existing ... -
Joint Multi-Fiber NODDI Parameter Estimation and Tractography Using the Unscented Information Filter
(Frontiers Media S.A., 2016)Tracing white matter fiber bundles is an integral part of analyzing brain connectivity. An accurate estimate of the underlying tissue parameters is also paramount in several neuroscience applications. In this work, we ... -
Joint Registration and Clustering of Images
(Wiley, 2007)We demonstrate an EM-based algorithm that jointly registers and clusters a group of images using an affine transformation model. The output is a small number of prototype images that represent the different modes of the ... -
Joint Replacement Medical Mission Trips Can Provide High Quality Care in Developing Countries: Assessing Quality Using the Structure, Process, and Outcomes Paradigm
(2016-05-17)Background: Medical mission trips that go to developing countries are becoming more popular worldwide and there is need for rigorous quality assessment of the care that these trips provide. Current scrutiny of these trips ... -
JunB Mediates Basal- and TGFβ1-Induced Smooth Muscle Cell Contractility
(Public Library of Science, 2013)Smooth muscle contraction is a dynamic process driven by acto-myosin interactions that are controlled by multiple regulatory proteins. Our studies have shown that members of the AP-1 transcription factor family control ...