Browsing Harvard Medical School by Title
Now showing items 9648-9667 of 18423
-
K63 polyubiquitination is a new modulator of the oxidative stress response
(2014)Ubiquitination is a post-translational modification that signals multiple processes, including protein degradation, trafficking, and DNA repair. Polyubiquitin accumulates globally during the oxidative stress response, which ... -
Kainate Receptor-Mediated Modulation of Hippocampal Fast Spiking Interneurons in a Rat Model of Schizophrenia
(Public Library of Science, 2012)Kainate receptor (KAR) subunits are believed to be involved in abnormal GABAergic neurotransmission in the hippocampus (HIPP) in schizophrenia (SZ) and bipolar disorder. Postmortem studies have shown changes in the expression ... -
Kangaroo mother care: a systematic review of barriers and enablers
(World Health Organization, 2016)Abstract Objective: To investigate factors influencing the adoption of kangaroo mother care in different contexts. Methods: We searched PubMed, Embase, Scopus, Web of Science and the World Health Organization’s regional ... -
Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence
(National Academy of Sciences, 2014)Kaposi's sarcoma-associated herpesvirus (KSHV) latently infects tumor cells and persists as a multiple-copy, extrachromosomal, circular episome. To persist, the viral genome must replicate with each cell cycle. The KSHV ... -
Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Bromodomain Protein Brd4 on Host Mitotic Chromosomes
(American Society for Microbiology, 2006)The latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus (KSHV) is required for viral episome maintenance in host cells during latent infection. Two regions of the protein have been implicated ... -
Kaposi’s Sarcoma Herpesvirus Genome Persistence
(Frontiers Media S.A., 2016)Kaposi’s sarcoma-associated herpesvirus (KSHV) has an etiologic role in Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. These diseases are most common in immunocompromised individuals, ... -
Kappa‐opioid receptors differentially regulate low and high levels of ethanol intake in female mice
(John Wiley and Sons Inc., 2016)Abstract Introduction: Studies in laboratory animals and humans indicate that endogenous opioids play an important role in regulating the rewarding value of various drugs, including ethanol (EtOH). Indeed, opioid antagonists ... -
Karma and Ayurveda
(Medknow Publications & Media Pvt Ltd, 1987)Belief in the role of Karma explains a variety of Phenomena in India. For a traditional medical system such as Ayurveda, the conflict between simultaneously held beliefs in fatalism and the efficacy of medical interventions ... -
KCTD13 is a Major Driver of Mirrored Neuroanatomical Phenotypes Associated with the 16p11.2 CNV
(Nature Publishing Group, 2012)Copy number variants (CNVs) are major contributors to genetic disorders1. We have dissected a region of the 16p11.2 chromosome—which encompasses 29 genes—that confers susceptibility to neurocognitive defects when deleted ... -
KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival
(Springer Nature, 2017)Recent studies have delineated cancer type-specific roles of histone 3 lysine 27 (H3K27) demethylase KDM6B/JMJD3 depending on its H3K27 demethylase activity. Here we show that KDM6B is expressed in multiple myeloma (MM); ... -
Kdo Hydrolase Is Required for Francisella tularensis Virulence and Evasion of TLR2-Mediated Innate Immunity
(American Society of Microbiology, 2013)ABSTRACT The highly virulent Francisella tularensis subsp. tularensis has been classified as a category A bioterrorism agent. A live vaccine strain (LVS) has been developed but remains unlicensed in the United States because ... -
The kdr-bearing haplotype and susceptibility to Plasmodium falciparum in Anopheles gambiae: genetic correlation and functional testing
(BioMed Central, 2015)Background: Members of the Anophelesgambiae species complex are primary vectors of human malaria in Africa. It is known that a large haplotype shared between An. gambiae and Anophelescoluzzii by introgression carries point ... -
Kelch proteins: emerging roles in skeletal muscle development and diseases
(BioMed Central, 2014)Our understanding of genes that cause skeletal muscle disease has increased tremendously over the past three decades. Advances in approaches to genetics and genomics have aided in the identification of new pathogenic ... -
Keloids and Hypertrophic Scars: Update and Future Directions
(Wolters Kluwer Health, 2013)Summary: The development of cutaneous pathological scars, namely, hypertrophic scars (HSs) and keloids, involves complex pathways, and the exact mechanisms by which they are initiated, evolved, and regulated remain to be ... -
Keratins Regulate Protein Biosynthesis Through Localization of GLUT1 and -3 Upstream of AMP Kinase and Raptor
(The Rockefeller University Press, 2009)Keratin intermediate filament proteins form cytoskeletal scaffolds in epithelia, the disruption of which affects cytoarchitecture, cell growth, survival, and organelle transport. However, owing to redundancy, the global ... -
Keratocyte Apoptosis and Failure of Corneal Allografts
(Ovid Technologies (Wolters Kluwer Health), 2006)Background Murine models of high-risk and low-risk corneal transplantation were used to determine the role of keratocyte apoptosis in the failure of orthotopic allogeneic corneal transplants. Materials and Methods Normal ... -
KERIS: kaleidoscope of gene responses to inflammation between species
(Oxford University Press, 2017)A cornerstone of modern biomedical research is the use of animal models to study disease mechanisms and to develop new therapeutic approaches. In order to help the research community to better explore the similarities and ... -
A Kernel-Based Approach for User-Guided Fiber Bundling using Diffusion Tensor Data
(2006)This paper describes a novel user-guided method for grouping fibers from diffusion tensor MRI tractography into bundles. The method finds fibers, that passing through user-defined ROIs, still fit to the underlying data ... -
Key clinical beam parameters for nanoparticle-mediated radiation dose amplification
(Nature Publishing Group, 2016)As nanoparticle solutions move towards human clinical trials in radiation therapy, the influence of key clinical beam parameters on therapeutic efficacy must be considered. In this study, we have investigated the clinical ... -
Key Concepts for Estimating the Burden of Surgical Conditions and the Unmet Need for Surgical Care
(Springer-Verlag, 2009)Background: Surgical care is emerging as a crucial issue in global public health. Methodology is needed to assess the impact of surgical care from a public health perspective. Methods: A consensus opinion of a group of ...