Now showing items 9710-9729 of 18423

    • l(1)pole hole is required maternally for pattern formation in the terminal regions of the embryo 

      Ambrosio, Linda; Mahowald, Anthony P.; Perrimon, Norbert (1989)
      Maternal expression of the l(l)pole hole (l(l)ph) gene product is required for the development of the Drosophila embryo. When maternal l(l)ph activity is ab- sent, alterations in the embryonic fate map occur as visualized ...
    • LAB-1 Targets PP1 and Restricts Aurora B Kinase upon Entrance into Meiosis to Promote Sister Chromatid Cohesion 

      Egydio de Carvalho, Carlos; Van Bostelen, Ivo; Gu, Yanjie; Chu, Diana S.; Cheeseman, Iain M.; Tzur, Yonatan B; Nadarajan, Saravanapriah; Colaiacovo, Monica P. (Public Library of Science, 2012)
      Successful execution of the meiotic program depends on the timely establishment and removal of sister chromatid cohesion. LAB-1 has been proposed to act in the latter by preventing the premature removal of the meiosis-specific ...
    • Label Space: A Coupled Multi-shape Representation 

      Malcolm, James; Rathi, Yogesh; Shenton, Martha Elizabeth; Tannenbaum, Allen (Springer Science + Business Media, 2008)
      Richly labeled images representing several sub-structures of an organ occur quite frequently in medical images. For example, a typical brain image can be labeled into grey matter, white matter or cerebrospinal fluid, each ...
    • Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor 

      Im, Hyungsoon; Shao, Huilin; Park, Yong Il; Peterson, Vanessa M.; Castro, Cesar M.; Weissleder, Ralph; Lee, Hakho (Nature Research, 2014)
      Exosomes show potential for cancer diagnostics because they transport molecular contents of the cells from which they originate. Detection and molecular profiling of exosomes is technically challenging and often requires ...
    • LabKey Server NAb: A Tool for Analyzing, Visualizing and Sharing Results from Neutralizing Antibody Assays 

      Piehler, Britt; Nelson, Elizabeth K.; Eckels, Josh; Ramsay, Sarah; Lum, Karl; Wood, Blake; Greene, Kelli M.; Gao, Hongmei; Montefiori, David C.; Igra, Mark; Seaman, Michael S. (BioMed Central, 2011)
      Background: Multiple types of assays allow sensitive detection of virus-specific neutralizing antibodies. For example, the extent of antibody neutralization of HIV-1, SIV and SHIV can be measured in the TZM-bl cell line ...
    • A Laboratory Driving Simulation for Assessment of Driving Behavior in Adults with ADHD: A Controlled Study 

      Monuteaux, Michael C; Reimer, Bryan; Coughlin, Joseph F; Aleardi, Megan; Dougherty, Meghan; Schoenfeld, Steven; Biederman, Joseph; Fried, Ronna; Surman, Craig B.H.; Spencer, Thomas J.; Faraone, Stephen V. (BioMed Central, 2007)
      Background: It is now estimated that attention deficit-hyperactivity disorder (ADHD) afflicts at least 4% of adults in the United States and is associated with high levels of morbidity and functional impairment. One key ...
    • Laboratory evolution of a sortase enzyme that modifies amyloid-β protein 

      Podracky, Christopher J.; An, Chihui; DeSousa, Alexandra; Dorr, Brent M.; Walsh, Dominic M.; Liu, David (Springer Science and Business Media LLC, 2021-01-11)
    • Laboratory-Based Prospective Surveillance for Community Outbreaks of Shigella spp. in Argentina 

      Viñas, María R.; Tuduri, Ezequiel; Galar, Alicia; Yih, Katherine; Pichel, Mariana; Stelling, John; Brengi, Silvina P.; Della Gaspera, Anabella; van der Ploeg, Claudia; Bruno, Susana; Rogé, Ariel; Caffer, María I.; Kulldorff, Martin; Galas, Marcelo (Public Library of Science, 2013)
      Background: To implement effective control measures, timely outbreak detection is essential. Shigella is the most common cause of bacterial diarrhea in Argentina. Highly resistant clones of Shigella have emerged, and ...
    • Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review 

      Ravnskov, Uffe; Diamond, David M; Hama, Rokura; Hamazaki, Tomohito; Hammarskjöld, Björn; Hynes, Niamh; Kendrick, Malcolm; Langsjoen, Peter H; Malhotra, Aseem; Mascitelli, Luca; McCully, Kilmer S; Ogushi, Yoichi; Okuyama, Harumi; Rosch, Paul J; Schersten, Tore; Sultan, Sherif; Sundberg, Ralf (BMJ Publishing Group, 2016)
      Objective: It is well known that total cholesterol becomes less of a risk factor or not at all for all-cause and cardiovascular (CV) mortality with increasing age, but as little is known as to whether low-density lipoprotein ...
    • Lack of Association Between 25(OH)D Levels and Incident Type 2 Diabetes in Older Women 

      Larson, Joseph; Liu, Simin; Howard, Barbara V.; Phillips, Lawrence; Shikany, James M.; Allison, Matthew; Curb, J. David; Johnson, Karen C.; Watts, Nelson; Robinson, Jennifer G.; Manson, JoAnn Elisabeth; Song, Yiqing (American Diabetes Association, 2011)
      Objective: To examine whether lower serum levels of serum 25-hydroxyvitamin (OH) D [25(OH)D] are associated with increased risk of developing type 2 diabetes. Research Design and Methods: A post hoc analysis of three nested ...
    • Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study 

      Hornig, Mady; Briese, Thomas; Siemetzki, Ulrike; Hummel, Kimberly; Rota, Paul A.; Bellini, William J.; Sheils, Orla; Alden, Errol; Pickering, Larry; Lipkin, W. Ian; Cookson, Mark R.; Buie, Timothy M.; Bauman, Margaret Estelle Lang; Lauwers, Gregory Y.; O'Leary, John J. (Public Library of Science, 2008)
      Background: The presence of measles virus (MV) RNA in bowel tissue from children with autism spectrum disorders (ASD) and gastrointestinal (GI) disturbances was reported in 1998. Subsequent investigations found no associations ...
    • Lack of Association of Polymorphisms in Homocysteine Metabolism Genes with Pseudoexfoliation Syndrome and Glaucoma 

      Fan, Baojian; Chen, Teresa Chia-Ching; Grosskreutz, Cynthia Lee; Pasquale, Louis; Rhee, Douglas J; DelBono, Elizabeth; Haines, Jonathan L.; Wiggs, Janey Lee (Molecular Vision, 2008)
      Purpose: To evaluate genes involved in homocysteine metabolism as secondary risk factors for pseudoexfoliation syndrome (PXFS) and the associated glaucoma (PXFG). Methods: One hundred eighty-six unrelated patients with ...
    • Lack of Association of Rare Functional Variants in TSC1/TSC2 Genes with Autism Spectrum Disorder 

      Bahl, Samira; Chiang, Colby; Beauchamp, Roberta L; Neale, Benjamin Michael; Daly, Mark Joseph; Gusella, James Francis; Talkowski, Michael Edward; Ramesh, Vijaya (BioMed Central, 2013)
      Background: Autism spectrum disorder (ASD) is reported in 30 to 60% of patients with tuberous sclerosis complex (TSC) but shared genetic mechanisms that exist between TSC-associated ASD and idiopathic ASD have yet to be ...
    • Lack of Cholesterol Awareness among Physicians Who Smoke 

      Scranton, Richard E.; Farwell, Wildon Randal; Gaziano, John Michael (Molecular Diversity Preservation International (MDPI), 2009)
      Cigarette use is a known risk factor for the development of coronary artery disease (CAD) as it adversely affects HDL cholesterol levels and promotes thrombogenesis. Smoking may also be associated with behavioral characteristics ...
    • Lack of Correlation Between Pulmonary Disease and Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Cystic Fibrosis: A Case Report 

      Levy, Hara; Cannon, Carolynn L; Asher, Daniel; García, Christopher; Cleveland, Robert Harris; Pier, Gerald B.; Knowles, Michael R; Colin, Andrew A (BioMed Central, 2010)
      Introduction: Mutations in both alleles of the cystic fibrosis transmembrane conductance regulator gene result in the disease cystic fibrosis, which usually manifests as chronic sinopulmonary disease, pancreatic insufficiency, ...
    • Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals 

      Brainard, Diana M.; Rathod, Almas; Piechocka-Trocha, Alicja; Fideli, Ulgen; Mulenga, Joseph; Shutes, Erin; Alvino, Donna Marie L.; Hunter, Eric; Allen, Susan A.; Addo, Marylyn Martina; Altfeld, Marcus; Walker, Bruce David (Oxford University Press, 2011)
      Human immunodeficiency virus type 1 (HIV-1)–specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. ...
    • Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions 

      Tang, E. H. C.; Shimizu, K.; Christen, T.; Rocha, V. Z.; Shvartz, E.; Tesmenitsky, Y.; Sukhova, Galina K.; Shi, Guo-Ping; Libby, Peter (Oxford University Press (OUP), 2010)
      Aim: Prostaglandin E2, by ligation of its receptor EP4, suppresses the production of inflammatory cytokines and chemokines in macrophages in vitro. Thus, activation of EP4 may constitute an endogenous anti-inflammatory ...
    • Lack of impact of mild obstructive sleep apnea on sleepiness, mood and quality of life 

      Quan, Stuart Fun; Budhiraja, Rohit; Batool-Anwar, Salma; Gottlieb, Daniel J; Eichling, Phillip; Patel, Sanjay R; Shen, Wei; Walsh, James; Kushida, Clete (Southwest Journal of Pulmonary and Critical Care, 2014)
      Background and Objectives: Obstructive sleep apnea (OSA) is associated with sleepiness, depression and reduced quality of life. However, it is unclear whether mild OSA has these negative impacts. Using data from the Apnea ...
    • Lack of mature lymphocytes results in obese but metabolically healthy mice when fed a high-fat diet 

      Liu, Xiaowen; Huh, Joo Young; Gong, Huizhi; Chamberland, John; Hamnvik, Ole-Petter Riksfjord; Mantzoros, Christos (Springer Science and Business Media LLC, 2015-05-21)
      Background/Objectives: Obesity is characterized by chronic inflammation and immune dysregulation, as well as insulin resistance, but the link between obesity and adaptive immunity remains to be fully studied. Methods: To ...
    • Lack of PD-L1 Expression by iNKT Cells Improves the Course of Influenza A Infection 

      Maazi, Hadi; Singh, Abinav K.; Speak, Anneliese O.; Lombardi, Vincent; Lam, Jonathan; Khoo, Bryant; Inn, Kyung Soo; Sharpe, Arlene Helen; Jung, Jae U.; Akbari, Omid (Public Library of Science, 2013)
      There is evidence indicating that invariant Natural Killer T (iNKT) cells play an important role in defense against influenza A virus (IAV). However, the effect of inhibitory receptor, programmed death-1 (PD-1), and its ...