Browsing Harvard Medical School by Keyword "ATM"
Now showing items 1-2 of 2
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DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction
(Impact Journals LLC, 2012)The Mdm2 oncoprotein promotes p53 ubiquitination and destruction. Yet, exact molecular mechanisms of Mdm2 destruction itself, under DNA damaging conditions, remain unclear. Recently, we identified SCFβ-TRCP as a novel E3 ... -
Targeted ultra-deep sequencing reveals recurrent and mutually exclusive mutations of cancer genes in blastic plasmacytoid dendritic cell neoplasm
(Impact Journals LLC, 2014)Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare haematopoietic malignancy characterized by dismal prognosis and overall poor therapeutic response. Since the biology of BPDCN is barely understood, our study ...