Browsing Harvard Medical School by Keyword "Alzheimer's disease"

Now showing items 1-20 of 24

    • Alzheimer's Disease Amyloid-\(\beta\) Links Lens and Brain Pathology in Down Syndrome 

      Moncaster, Juliet A.; Lu, Suqian; Burton, Mark A.; Ghosh, Joy G.; Soscia, Stephanie J.; Mocofanescu, Anca; Kuszak, Jer R.; Pineda, Roberto; Moir, Robert D.; Ericsson, Maria; Folkerth, Rebecca Dunn; Robb, Richard Moore; Clark, John I.; Tanzi, Rudolph Emile; Hunter, David; Goldstein, Lee David (Public Library of Science, 2010)
      Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication of chromosome 21 invariably includes the APP gene (21q21) ...

    • The Alzheimer's Disease-Associated Amyloid \(\beta\)-Protein Is an Antimicrobial Peptide 

      Soscia, Stephanie; Kirby, James Edward; Washicosky, Kevin J.; Tucker, Stephanie; Ingelsson, Martin; Hyman, Bradley Theodore; Burton, Mark A.; Duong, Scott; Tanzi, Rudolph Emile; Moir, Robert D.; Goldstein, Lee E. (Public Library of Science, 2010)
      Background: The amyloid \(\beta\)-protein (A\(\beta\)) is believed to be the key mediator of Alzheimer's disease (AD) pathology. A\(\beta\) is most often characterized as an incidental catabolic byproduct that lacks a ...

    • The Alzheimer’s Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide 

      Kirby, James Edward; Washicosky, Kevin J.; Tucker, Stephanie M.; Ingelsson, Martin; Hyman, Bradley Theodore; Burton, Mark A.; Goldstein, Lee E.; Duong, Scott; Tanzi, Rudolph Emile; Moir, Robert D. (Public Library of Science, 2010)
      Background: The amyloid β-protein (Aβ) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. ...

    • The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase 

      Bolduc, David M; Montagna, Daniel R; Seghers, Matthew C; Wolfe, Michael S; Selkoe, Dennis J (eLife Sciences Publications, Ltd, 2016)
      γ-secretase is responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-prone amyloid-beta (Aβ) peptides, which are centrally implicated in the pathogenesis of Alzheimer’s disease (AD). ...

    • Biomarker-based prediction of progression in MCI: Comparison of AD signature and hippocampal volume with spinal fluid amyloid-β and tau 

      Dickerson, Bradford C.; Wolk, David A. (Frontiers Media S.A., 2013)
      Objective: New diagnostic criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) have been developed using biomarkers aiming to establish whether the clinical syndrome is likely due to underlying AD. ...

    • Characterization of Age-Dependent and Progressive Cortical Neuronal Degeneration in Presenilin Conditional Mutant Mice 

      Wines-Samuelson, Mary; Schulte, Eva C.; Smith, Miriam J.; Aoki, Chiye; Liu, Xinran; Cookson, Mark R.; Kelleher, Raymond J.; Shen, Jie (Public Library of Science, 2010)
      Presenilins are the major causative genes of familial Alzheimer's disease (AD). Our previous study has demonstrated essential roles of presenilins in memory and neuronal survival. Here, we explore further how loss of ...

    • Cross-View Neuroimage Pattern Analysis in Alzheimer's Disease Staging 

      Liu, Sidong; Cai, Weidong; Pujol, Sonia; Kikinis, Ron; Feng, Dagan D. (Frontiers Media S.A., 2016)
      The research on staging of pre-symptomatic and prodromal phase of neurological disorders, e.g., Alzheimer's disease (AD), is essential for prevention of dementia. New strategies for AD staging with a focus on early detection, ...

    • Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function 

      Kim, B M; You, M-H; Chen, C-H; Lee, S; Hong, Y; Kimchi, A; Zhou, X Z; Lee, T H (Nature Publishing Group, 2014)
      The presence of tangles composed of phosphorylated tau is one of the neuropathological hallmarks of Alzheimer's disease (AD). Tau, a microtubule (MT)-associated protein, accumulates in AD potentially as a result of ...

    • Dementia and Race: Are There Differences Between African Americans and Caucasians? 

      Inouye, Sharon; Miles, Toni; Froehlich, Tanya; Bogardus, Sidney (Wiley-Blackwell, 2001)
      This study provides an overview of racial differences in etiology and prevalence of dementia. Preliminary findings indicate that the clinical and molecular etiologies of dementia differ between races. African Americans ...

    • Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?☆ 

      Whitwell, Jennifer L.; Tosakulwong, Nirubol; Weigand, Stephen D.; Senjem, Matthew L.; Lowe, Val J.; Gunter, Jeffrey L.; Boeve, Bradley F.; Knopman, David S.; Dickerson, Bradford C.; Petersen, Ronald C.; Jack, Clifford R. (Elsevier, 2013)
      The objective of our study was to evaluate whether cognitively normal (CN) elderly participants showing elevated cortical beta-amyloid (Aβ) deposition have a consistent neuroanatomical signature of brain atrophy that may ...

    • Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia 

      Spires-Jones, Tara L.; Fox, Leora M.; Rozkalne, Anete; Pitstick, Rose; Carlson, George A.; Kazantsev, Aleksey G. (Frontiers Research Foundation, 2012)
      Tauopathies including tau-associated Frontotemporal dementia (FTD) and Alzheimer’s disease are characterized pathologically by the formation of tau-containing neurofibrillary aggregates and neuronal loss, which contribute ...

    • Intelligence quotient–adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion 

      Rentz, Dorene May; Huh, Terri J.; Sardinha, Lisa M.; Moran, Erin K.; Becker, John Alex; Daffner, Kirk R.; Sperling, Reisa Anne; Johnson, Keith Alan (Cambridge University Press (CUP), 2007)
      Cognitive reserve among highly intelligent older individuals makes detection of early Alzheimer's disease (AD) difficult. We tested the hypothesis that mild memory impairment determined by IQ-adjusted norms is associated ...

    • Lessons from a Rare Familial Dementia: Amyloid and Beyond 

      Cantlon, Adam; Frigerio, Carlo Sala; Walsh, Dominic M. (2015)
      Here we review the similarities between a rare inherited disorder, familial British dementia (FBD), and the most common of all late-life neurological conditions, Alzheimer's diseases (AD). We describe the symptoms, pathology ...

    • Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo 

      Khurana, Vikram; Elson-Schwab, Ilan; Fulga, Tudor Alexandru; Sharp, Katherine A.; Loewen, Carin A.; Mulkearns, Erin; Tyynelä, Jaana; Scherzer, Clemens; Feany, Mel B. (Public Library of Science, 2010)
      Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal ...

    • MIND diet associated with reduced incidence of Alzheimer's disease 

      Morris, Martha Clare; Tangney, Christy C.; Wang, Yamin; Sacks, Frank Martin; Bennett, David William; Aggarwal, Neelum T. (Elsevier BV, 2015)
      INTRODUCTION: In a previous study, higher concordance to the MIND diet, a hybrid Mediterranean-Dietary Approaches to Stop Hypertension diet, was associated with slower cognitive decline. In this study we related these ...

    • Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study 

      Frost, Jeffrey L.; Liu, Bin; Kleinschmidt, Martin; Schilling, Stephan; Demuth, Hans-Ulrich; Lemere, Cynthia A. (S. Karger AG, 2012)
      Background: N-terminally truncated and modified pyroglutamate-3 amyloid-β protein (pE3-Aβ) is present in most, if not all, cerebral plaque and vascular amyloid deposits in human Alzheimer's disease (AD). pE3-Aβ deposition ...

    • Patients With Mild Alzheimer's Disease Attribute Conceptual Fluency to Prior Experience 

      Wolk, David A.; Schacter, Daniel L.; Berman, Alyssa R.; Holcomb, Phillip J.; Daffner, Kirk; Budson, Andrew E. (Elsevier BV, 2005)
      Patients with Alzheimer's disease (AD) have been found to be relatively dependent on familiarity in their recognition memory judgments. Conceptual fluency has been argued to be an important basis of familiarity. This study ...

    • Physiological and Pathological Role of Alpha-Synuclein in Parkinson’s Disease through Iron Mediated Oxidative Stress; The Role of a Putative Iron-Responsive Element 

      Olivares, David; Huang, Xudong; Branden, Lars; Greig, Nigel H.; Rogers, Jack Timothy (Molecular Diversity Preservation International (MDPI), 2009)
      Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder after Alzheimer’s disease (AD) and represents a large health burden to society. Genetic and oxidative risk factors have been proposed ...

    • Retinal blood flow in mild cognitive impairment and Alzheimer's disease 

      Feke, Gilbert T.; Hyman, Bradley T.; Stern, Robert A.; Pasquale, Louis R. (Elsevier, 2015)
      Background: Patients with Alzheimer's disease (AD) demonstrate the narrowing of retinal veins and decreased retinal venous blood flow compared with control subjects. We assessed whether these abnormalities are present in ...

    • The SORL1 Gene and Convergent Neural Risk for Alzheimer's Disease Across the Human Lifespan 

      Felsky, Daniel; Szeszko, Philip; Yu, Lei; Honer, William G; De Jager, Philip L; Schneider, Julie A; Malhotra, Anil K; Lencz, Todd; Ikuta, Toshikazu; Pipitone, Jon; Chakravarty, M Mallar; Lobaugh, Nancy J; Mulsant, Benoit H; Pollock, Bruce G; Kennedy, James L; Bennett, David A; Voineskos, Aristotle N (2013)
      Prior to intervention trials in individuals genetically at-risk for late-onset Alzheimer's disease, critical first steps are identifying where (neuroanatomic effects), when (timepoint in the lifespan) and how (gene expression ...