Browsing Harvard Medical School by Keyword "Amino Acids"

Now showing items 1-6 of 6

    • Addition of Alanyl-Glutamine to Dialysis Fluid Restores Peritoneal Cellular Stress Responses – A First-In-Man Trial 

      Kratochwill, Klaus; Boehm, Michael; Herzog, Rebecca; Gruber, Katharina; Lichtenauer, Anton Michael; Kuster, Lilian; Csaicsich, Dagmar; Gleiss, Andreas; Alper, Seth L.; Aufricht, Christoph; Vychytil, Andreas (Public Library of Science, 2016)
      Background: Peritonitis and ultrafiltration failure remain serious complications of chronic peritoneal dialysis (PD). Dysfunctional cellular stress responses aggravate peritoneal injury associated with PD fluid exposure, ...

    • Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil 

      Guerrant, Richard L.; Leite, Alvaro M.; Pinkerton, Relana; Medeiros, Pedro H. Q. S.; Cavalcante, Paloma A.; DeBoer, Mark; Kosek, Margaret; Duggan, Christopher; Gewirtz, Andrew; Kagan, Jonathan C.; Gauthier, Anna E.; Swann, Jonathan; Mayneris-Perxachs, Jordi; Bolick, David T.; Maier, Elizabeth A.; Guedes, Marjorie M.; Moore, Sean R.; Petri, William A.; Havt, Alexandre; Lima, Ila F.; Prata, Mara de Moura Gondim; Michaleckyj, Josyf C.; Scharf, Rebecca J.; Sturgeon, Craig; Fasano, Alessio; Lima, Aldo A. M. (Public Library of Science, 2016)
      Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and ...

    • Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study 

      Nowak, Christoph; Salihovic, Samira; Ganna, Andrea; Brandmaier, Stefan; Tukiainen, Taru; Broeckling, Corey D.; Magnusson, Patrik K.; Prenni, Jessica E.; Wang-Sattler, Rui; Peters, Annette; Strauch, Konstantin; Meitinger, Thomas; Giedraitis, Vilmantas; Ärnlöv, Johan; Berne, Christian; Gieger, Christian; Ripatti, Samuli; Lind, Lars; Pedersen, Nancy L.; Sundström, Johan; Ingelsson, Erik; Fall, Tove (Public Library of Science, 2016)
      Insulin resistance (IR) and impaired insulin secretion contribute to type 2 diabetes and cardiovascular disease. Both are associated with changes in the circulating metabolome, but causal directions have been difficult to ...

    • HIF1α and HIF2α Exert Distinct Nutrient Preferences in Renal Cells 

      Arreola, Alexandra; Cowey, C. Lance; Coloff, Jonathan L.; Rathmell, Jeffrey C.; Rathmell, W. Kimryn (Public Library of Science, 2014)
      Background: Hypoxia Inducible Factors (HIF1α and HIF2α) are commonly stabilized and play key roles related to cell growth and metabolic programming in clear cell renal cell carcinoma. The relationship of these factors to ...

    • The Outer Pore and Selectivity Filter of TRPA1 

      Christensen, Adam P.; Akyuz, Nurunisa; Corey, David P. (Public Library of Science, 2016)
      TRPA1 (transient-receptor-potential-related ion channel with ankyrin domains) is a direct receptor or indirect effector for a wide variety of nociceptive signals, and thus is a compelling target for development of analgesic ...

    • Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins 

      Sun, Zhen-Yu J.; Bhanu, Meera K.; Allan, Martin G.; Arthanari, Haribabu; Wagner, Gerhard; Hanna, John (Public Library of Science, 2016)
      Zinc binding domains are common and versatile protein structural motifs that mediate diverse cellular functions. Among the many structurally distinct families of zinc finger (ZnF) proteins, the AN1 domain remains poorly ...