Browsing Harvard Medical School by Keyword "Anatomical Pathology"

Now showing items 1-13 of 13

    • Apocrine-Eccrine Carcinomas: Molecular and Immunohistochemical Analyses 

      Pawlak, Amanda C.; Cosper, Arjola K.; Deng, April; Horick, Nora K.; Le, Long Phi; Dias-Santagata, Dora; Selim, M. Angelica; Iafrate, Anthony John; Hoang, Mai P; Mihm, Martin Charles; Nguyen, Anh Thu (Public Library of Science, 2012)
      Apocrine-eccrine carcinomas are rare and associated with poor prognosis. Currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target cancer-promoting pathways may complement conventional ...

    • Causes of Death on Antiretroviral Therapy: A Post-Mortem Study from South Africa 

      Wong, Emily Beth; Omar, Tanvier; Setlhako, Gosetsemang J.; Osih, Regina; Feldman, Charles; Murdoch, David M.; Martinson, Neil A.; Bangsberg, David Roy; Venter, W. D. F. (Public Library of Science, 2012)
      Background: Mortality in the first months of antiretroviral therapy (ART) is a significant clinical problem in sub-Saharan Africa. To date, no post-mortem study has investigated the causes of mortality in these patients. ...

    • Characterization of Defects in Ion Transport and Tissue Development in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Knockout Rats 

      Tuggle, Katherine L.; Birket, Susan E.; Cui, Xiaoxia; Hong, Jeong; Warren, Joe; Reid, Lara; Chambers, Andre; Ji, Diana; Gamber, Kevin; Chu, Kengyeh K.; Tearney, Guillermo; Tang, Li Ping; Fortenberry, James A.; Du, Ming; Cadillac, Joan M.; Bedwell, David M.; Rowe, Steven M.; Sorscher, Eric J.; Fanucchi, Michelle V. (Public Library of Science, 2014)
      Animal models for cystic fibrosis (CF) have contributed significantly to our understanding of disease pathogenesis. Here we describe development and characterization of the first cystic fibrosis rat, in which the cystic ...

    • Computational Pathology to Discriminate Benign from Malignant Intraductal Proliferations of the Breast 

      Dong, Fei; Irshad, Humayun; Oh, Eun-Yeong; Lerwill, Melinda F.; Brachtel, Elena F.; Jones, Nicholas C.; Knoblauch, Nicholas W.; Montaser-Kouhsari, Laleh; Johnson, Nicole B.; Rao, Luigi K. F.; Faulkner-Jones, Beverly; Wilbur, David C.; Schnitt, Stuart J.; Beck, Andrew H. (Public Library of Science, 2014)
      The categorization of intraductal proliferative lesions of the breast based on routine light microscopic examination of histopathologic sections is in many cases challenging, even for experienced pathologists. The development ...

    • Cost-Effectiveness Analysis: Risk Stratification of Nonalcoholic Fatty Liver Disease (NAFLD) by the Primary Care Physician Using the NAFLD Fibrosis Score 

      Tapper, Elliot B.; Hunink, M. G. Myriam; Afdhal, Nezam H.; Lai, Michelle; Sengupta, Neil (Public Library of Science, 2016)
      Background: The complications of Nonalcoholic Fatty Liver Disease (NAFLD) are dependent on the presence of advanced fibrosis. Given the high prevalence of NAFLD in the US, the optimal evaluation of NAFLD likely involves ...

    • Developmental Trajectories of Resting EEG Power: An Endophenotype of Autism Spectrum Disorder 

      Tierney, Adrienne Leigh; Gabard-Durnam, Laurel; Vogel-Farley, Vanessa; Tager-Flusberg, Helen; Nelson, Charles A. (Public Library of Science, 2012)
      Current research suggests that autism spectrum disorder (ASD) is characterized by asynchronous neural oscillations. However, it is unclear whether changes in neural oscillations represent an index of the disorder or are ...

    • DNA Fragmentation Simulation Method (FSM) and Fragment Size Matching Improve aCGH Performance of FFPE Tissues 

      Craig, Justin M.; Vena, Natalie; Idbaih, Ahmed; Fouse, Shaun D.; Ozek, Memet; Sav, Aydin; Margraf, Linda R.; Eberhart, Charles G.; Norden, Andrew D.; Ramkissoon, Shakti; Hill, D. Ashley; Kieran, Mark W.; Wen, Patrick Yung Chih; Loda, Massimo; Santagata, Sandro; Ligon, Keith Lloyd; Ligon, Azra Hadi (Public Library of Science, 2012)
      Whole-genome copy number analysis platforms, such as array comparative genomic hybridization (aCGH) and single nucleotide polymorphism (SNP) arrays, are transformative research discovery tools. In cancer, the identification ...

    • Evaluation of New Morphometric Parameters of Neoangiogenesis in Human Colorectal Cancer Using Confocal Laser Endomicroscopy (CLE) and Targeted Panendothelial Markers 

      Ciocâlteu, Adriana; Săftoiu, Adrian; Cârţână, Tatiana; Gruionu, Lucian Gheorghe; Pirici, Daniel; Georgescu, Corneliu Cristian; Georgescu, Claudia-Valentina; Gheonea, Dan Ionuţ; Gruionu, Gabriel (Public Library of Science, 2014)
      The tumor microcirculation is characterized by an abnormal vascular network with dilated, tortuous and saccular vessels. Therefore, imaging the tumor vasculature and determining its morphometric characteristics represent ...

    • Histopathologic Alterations Associated with Global Gene Expression Due to Chronic Dietary TCDD Exposure in Juvenile Zebrafish 

      Liu, Qing; Spitsbergen, Jan M.; Cariou, Ronan; Huang, Chun-Yuan; Jiang, Nan; Goetz, Giles; Hutz, Reinhold J.; Tonellato, Peter J.; Carvan, Michael J. (Public Library of Science, 2014)
      The goal of this project was to investigate the effects and possible developmental disease implication of chronic dietary TCDD exposure on global gene expression anchored to histopathologic analysis in juvenile zebrafish ...

    • An MRI Study of Symptomatic Adhesive Capsulitis 

      Zhao, Wen; Zheng, Xiaofeng; Liu, Yuying; Yang, Wenlu; Amirbekian, Vardan; Diaz, Luis E.; Huang, Xudong (Public Library of Science, 2012)
      Background: Appilication of MR imaging to diagnose Adhesive Capsulitis (AC) has previously been described. However, there is insufficient information available for the MRI analysis of AC. This study is to describe and ...

    • Peritoneal Dissemination Complicating Morcellation of Uterine Mesenchymal Neoplasms 

      Seidman, Michael A.; Oduyebo, Titilope; Muto, Michael George; Crum, Christopher Paul; Nucci, Marisa Rose; Quade, Bradley Joseph (Public Library of Science, 2012)
      Background: Power morcellation has become a common technique for the minimally invasive resection of uterine leiomyomas. This technique is associated with dissemination of cellular material throughout the peritoneum. When ...

    • The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults 

      Valenca, Guilherme T.; Srivastava, Gyan P.; Oliveira-Filho, Jamary; White, Charles C.; Yu, Lei; Schneider, Julie A.; Buchman, Aron S.; Shulman, Joshua M.; Bennett, David A.; De Jager, Philip L. (Public Library of Science, 2016)
      Background and Objective Recently, we have shown that the Parkinson’s disease (PD) susceptibility locus MAPT (microtubule associated protein tau) is associated with parkinsonism in older adults without a clinical diagnosis ...

    • Virtual Hematoxylin and Eosin Transillumination Microscopy Using Epi-Fluorescence Imaging 

      Giacomelli, Michael G.; Husvogt, Lennart; Vardeh, Hilde; Faulkner-Jones, Beverly E.; Hornegger, Joachim; Connolly, James L.; Fujimoto, James G. (Public Library of Science, 2016)
      We derive a physically realistic model for the generation of virtual transillumination, white light microscopy images using epi-fluorescence measurements from thick, unsectioned tissue. We demonstrate this technique by ...