Browsing Harvard Medical School by Keyword "Arc"

Now showing items 1-2 of 2

    • Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses 

      Rudinskiy, Nikita; Hawkes, Jonathan M; Wegmann, Susanne; Kuchibhotla, Kishore V; Muzikansky, Alona; Betensky, Rebecca A; Spires-Jones, Tara L; Hyman, Bradley T (BioMed Central, 2014)
      Intraneuronal neurofibrillary tangles (NFTs) – a characteristic pathological feature of Alzheimer’s and several other neurodegenerative diseases – are considered a major target for drug development. Tangle load correlates ...

    • Temporal dynamics of a homeostatic pathway controlling neural network activity 

      Bateup, Helen S.; Denefrio, Cassandra L.; Johnson, Caroline A.; Saulnier, Jessica L.; Sabatini, Bernardo L. (Frontiers Media S.A., 2013)
      Neurons use a variety of mechanisms to homeostatically regulate neural network activity in order to maintain firing in a bounded range. One such process involves the bi-directional modulation of excitatory synaptic drive ...