Browsing Harvard Medical School by Keyword "BMP"

Now showing items 1-3 of 3

    • Normal Growth and Development in Mice Over-Expressing the CCN Family Member WISP3 

      Nakamura, Yukio; Cui, Yajun; Fernando, Carol; Kutz, Wendy E.; Warman, Matthew L. (Springer Verlag, 2009)
      Loss-of-function mutations in the gene WISP3 cause the autosomal recessive human skeletal disease Progressive Pseudorheumatoid Dysplasia, whereas mice with knockout mutations of Wisp3 have no phenotype. The lack of a ...

    • Segregation of striated and smooth muscle lineages by a Notch-dependent regulatory network 

      Applebaum, Mordechai; Ben-Yair, Raz; Kalcheim, Chaya (BioMed Central, 2014)
      Background: Lineage segregation from multipotent epithelia is a central theme in development and in adult stem cell plasticity. Previously, we demonstrated that striated and smooth muscle cells share a common progenitor ...

    • TAK1 is an Essential Regulator of BMP Signalling in Cartilage 

      Shim, Jae-Hyuck; Greenblatt, Matthew Blake; Xie, Min; Schneider, Michael D; Zou, Weigou; Zhai, Bo; Gygi, Steven P.; Glimcher, Laurie Hollis (Nature Publishing Group, 2009)
      TGFβ activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis. To analyse the in vivo function of ...