Browsing Harvard Medical School by Keyword "Biomarkers"

Now showing items 1-20 of 63

    • The Absence of Obstructive Sleep Apnea May Protect against Non-Alcoholic Fatty Liver in Patients Undergoing Bariatric Surgery 

      Corey, Kathleen Elizabeth; Misdraji, Joseph; Zheng, Zheng; Malecki, Kyle M.; Kneeman, Jacob; Gelrud, Louis; Chung, Raymond Taeyong (Public Library of Science, 2013)
      Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide and its progressive form, steatohepatitis, will be the leading indication for liver transplant by 2020. While risk ...

    • Alterations of Serum Levels of BDNF-Related miRNAs in Patients with Depression 

      Li, You-Jie; Xu, Mei; Gao, Zong-Hua; Wang, Ya-Qi; Yue, Zhen; Zhang, Yan-Xia; Li, Xin-Xin; Zhang, Can; Xie, Shu-Yang; Wang, Ping-Yu (Public Library of Science, 2013)
      Depression is a serious and potentially life-threatening mental disorder with unknown etiology. Emerging evidence shows that brain-derived neurotrophic factor (BDNF) and microRNAs (miRNAs) play critical roles in the etiology ...

    • Apocrine-Eccrine Carcinomas: Molecular and Immunohistochemical Analyses 

      Pawlak, Amanda C.; Cosper, Arjola K.; Deng, April; Horick, Nora K.; Le, Long Phi; Dias-Santagata, Dora; Selim, M. Angelica; Iafrate, Anthony John; Hoang, Mai P; Mihm, Martin Charles; Nguyen, Anh Thu (Public Library of Science, 2012)
      Apocrine-eccrine carcinomas are rare and associated with poor prognosis. Currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target cancer-promoting pathways may complement conventional ...

    • Assessment of pharmacogenomic agreement 

      Safikhani, Zhaleh; El-Hachem, Nehme; Quevedo, Rene; Smirnov, Petr; Goldenberg, Anna; Juul Birkbak, Nicolai; Mason, Christopher; Hatzis, Christos; Shi, Leming; Aerts, Hugo JWL; Quackenbush, John; Haibe-Kains, Benjamin (F1000Research, 2016)
      In 2013 we published an analysis demonstrating that drug response data and gene-drug associations reported in two independent large-scale pharmacogenomic screens, Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer ...

    • Association of N-Linked Glycoprotein Acetyls and Colorectal Cancer Incidence and Mortality 

      Chandler, Paulette D.; Akinkuolie, Akintunde O.; Tobias, Deirdre K.; Lawler, Patrick R.; Li, Chungying; Moorthy, M. Vinayaga; Wang, Lu; Duprez, Daniel A.; Jacobs, David R.; Glynn, Robert J.; Otvos, James; Connelly, Margery A.; Post, Wendy S.; Ridker, Paul M.; Manson, JoAnn E.; Buring, Julie E.; Lee, I-Min; Mora, Samia (Public Library of Science, 2016)
      Background: Acute phase proteins highlight the dynamic interaction between inflammation and oncogenesis. GlycA, a novel nuclear magnetic resonance (NMR) inflammatory marker that identifies primarily circulating N-acetyl ...

    • The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes 

      Carolan, Brendan J; Hughes, Grant; Morrow, Jarrett; Hersh, Craig P; O’Neal, Wanda K; Rennard, Stephen; Pillai, Sreekumar G; Belloni, Paula; Cockayne, Debra A; Comellas, Alejandro P; Han, Meilan; Zemans, Rachel L; Kechris, Katerina; Bowler, Russell P (BioMed Central, 2014)
      Rationale: Chronic obstructive pulmonary disease (COPD) is a phenotypically heterogeneous disease. In COPD, the presence of emphysema is associated with increased mortality and risk of lung cancer. High resolution computed ...

    • Associations of Radiomic Data Extracted from Static and Respiratory-Gated CT Scans with Disease Recurrence in Lung Cancer Patients Treated with SBRT 

      Huynh, Elizabeth; Coroller, Thibaud P.; Narayan, Vivek; Agrawal, Vishesh; Romano, John; Franco, Idalid; Parmar, Chintan; Hou, Ying; Mak, Raymond H.; Aerts, Hugo J. W. L. (Public Library of Science, 2017)
      Radiomics aims to quantitatively capture the complex tumor phenotype contained in medical images to associate them with clinical outcomes. This study investigates the impact of different types of computed tomography (CT) ...

    • Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil 

      Guerrant, Richard L.; Leite, Alvaro M.; Pinkerton, Relana; Medeiros, Pedro H. Q. S.; Cavalcante, Paloma A.; DeBoer, Mark; Kosek, Margaret; Duggan, Christopher; Gewirtz, Andrew; Kagan, Jonathan C.; Gauthier, Anna E.; Swann, Jonathan; Mayneris-Perxachs, Jordi; Bolick, David T.; Maier, Elizabeth A.; Guedes, Marjorie M.; Moore, Sean R.; Petri, William A.; Havt, Alexandre; Lima, Ila F.; Prata, Mara de Moura Gondim; Michaleckyj, Josyf C.; Scharf, Rebecca J.; Sturgeon, Craig; Fasano, Alessio; Lima, Aldo A. M. (Public Library of Science, 2016)
      Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and ...

    • The biomarkers of immune dysregulation and inflammation response in Parkinson disease 

      Chen, Li; Mo, Mingshu; Li, Guangning; Cen, Luan; Wei, Lei; Xiao, Yousheng; Chen, Xiang; Li, Shaomin; Yang, Xinling; Qu, Shaogang; Xu, Pingyi (BioMed Central, 2016)
      Parkinson’s disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histocompatibility ...

    • Blood RNA biomarker panel detects both left- and right-sided colorectal neoplasms: a case-control study 

      Chao, Samuel; Ying, Jay; Liew, Gailina; Marshall, Wayne; Liew, Choong-Chin; Burakoff, Robert (BioMed Central, 2013)
      Background: Colonoscopy is widely regarded to be the gold standard for colorectal cancer (CRC) detection. Recent studies, however, suggest that the effectiveness of colonoscopy is mostly confined to tumors on the left side ...

    • Blood-Based Biomarkers of Aggressive Prostate Cancer 

      Liong, Men Long; Lim, Chun Ren; Yang, Hengxuan; Chao, Samuel; Bong, Chin Wei; Leong, Wing Seng; Das, Prashanta Kumar; Loh, Chit Sin; Lau, Ban Eng; Yu, Choon Geok; Ooi, Edie Jian Jiek; Nam, Robert K.; Allen, Paul Denney; Steele, Graeme S.; Wassmann, Karl; Richie, Jerome Paul; Liew, Choong Chin (Public Library of Science, 2012)
      Purpose: Prostate cancer is a bimodal disease with aggressive and indolent forms. Current prostate-specific-antigen testing and digital rectal examination screening provide ambiguous results leading to both under-and ...

    • Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation 

      Kuo, Angera H; Ancukiewicz, Marek; Kozak, Kevin R; Yock, Torunn I; Padera, Timothy P (BioMed Central, 2015)
      Background: Thoracic and cardiac irradiation increases the risk of pulmonary and cardiovascular disease. In addition, radiation, often in combination with chemotherapy, can cause treatment-related pneumonitis. Previously, ...

    • Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome 

      Hall, Kathryn Tayo; Lembo, Anthony J.; Kirsch, Irving; Ziogas, Dimitrios C.; Douaiher, Jeffrey; Jensen, Karin; Conboy, Lisa Ann; Kelley, John Michael; Kokkotou, Efi G.; Kaptchuk, Ted Jack (Public Library of Science, 2012)
      Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in ...

    • Cellular Expression Profile for Interstitial Cells of Cajal in Bladder - A Cell Often Misidentified as Myocyte or Myofibroblast 

      Yu, Weiqun; Zeidel, Mark Lawrence; Hill, Warren Gary (Public Library of Science, 2012)
      Background: Interstitial cells of Cajal (ICC) have been identified in urinary bladder of several species, but their presence in mice remains uncertain. Meanwhile, dozens of reports indicate that dysregulation of connexin ...

    • Cervical Mucus Properties Stratify Risk for Preterm Birth 

      Critchfield, Agatha S.; Yao, Grace; Jaishankar, Aditya; Friedlander, Ronn S.; Lieleg, Oliver; Doyle, Patrick S.; McKinley, Gareth; House, Michael; Ribbeck, Katharina (Public Library of Science, 2013)
      Background: Ascending infection from the colonized vagina to the normally sterile intrauterine cavity is a well-documented cause of preterm birth. The primary physical barrier to microbial ascension is the cervical canal, ...

    • Circulating MicroRNAs: Association with Lung Function in Asthma 

      Kho, Alvin T.; Sharma, Sunita; Davis, Joshua S.; Spina, Joseph; Howard, Dagnie; McEnroy, Kevin; Moore, Kip; Sylvia, Jody; Qiu, Weiliang; Weiss, Scott T.; Tantisira, Kelan G. (Public Library of Science, 2016)
      Background: MicroRNAs are key transcriptional and network regulators previously associated with asthma susceptibility. However, their role in relation to asthma severity has not been delineated. Objective: We hypothesized ...

    • Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD 

      Sun, Wei; Kechris, Katerina; Jacobson, Sean; Drummond, M. Bradley; Hawkins, Gregory A.; Yang, Jenny; Chen, Ting-huei; Quibrera, Pedro Miguel; Anderson, Wayne; Barr, R. Graham; Basta, Patricia V.; Bleecker, Eugene R.; Beaty, Terri; Casaburi, Richard; Castaldi, Peter; Cho, Michael H.; Comellas, Alejandro; Crapo, James D.; Criner, Gerard; Demeo, Dawn; Christenson, Stephanie A.; Couper, David J.; Curtis, Jeffrey L.; Doerschuk, Claire M.; Freeman, Christine M.; Gouskova, Natalia A.; Han, MeiLan K.; Hanania, Nicola A.; Hansel, Nadia N.; Hersh, Craig P.; Hoffman, Eric A.; Kaner, Robert J.; Kanner, Richard E.; Kleerup, Eric C.; Lutz, Sharon; Martinez, Fernando J.; Meyers, Deborah A.; Peters, Stephen P.; Regan, Elizabeth A.; Rennard, Stephen I.; Scholand, Mary Beth; Silverman, Edwin K.; Woodruff, Prescott G.; O’Neal, Wanda K.; Bowler, Russell P. (Public Library of Science, 2016)
      Implementing precision medicine for complex diseases such as chronic obstructive lung disease (COPD) will require extensive use of biomarkers and an in-depth understanding of how genetic, epigenetic, and environmental ...

    • Diagnostic Immunohistochemistry in Cutaneous Neoplasia: An Update 

      Compton, Leigh A.; Murphy, George F.; Lian, Christine G. (S. Karger AG, 2015)
      Immunohistochemistry (IHC) is an important adjunct in the diagnosis of neoplastic skin diseases. In addition to the many established IHC markers currently in use, new markers continue to emerge, although their general ...

    • The diagnostic value of circulating microRNAs for middle-aged (40–60-year-old) coronary artery disease patients 

      Md Sayed, Ali Sheikh; Xia, Ke; Li, Fei; Deng, Xu; Salma, Umme; Li, Tingbo; Deng, Hai; Yang, Dafeng; Haoyang, Zhou; Yang, TianLun; Peng, Jun (Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 2015)
      OBJECTIVE: Circulating microRNAs have been recognized as promising biomarkers for various diseases. The present study aimed to explore the potential roles of circulating miR-149, miR-424 and miR-765 as non-invasive biomarkers ...

    • Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten? 

      Volta, Umberto; Pinto-Sanchez, Maria Ines; Boschetti, Elisa; Caio, Giacomo; De Giorgio, Roberto; Verdu, Elena F (Korean Society of Neurogastroenterology and Motility, 2016)
      A tight link exists between dietary factors and irritable bowel syndrome (IBS), one of the most common functional syndromes, characterized by abdominal pain/discomfort, bloating and alternating bowel habits. Amongst the ...