Browsing Harvard Medical School by Keyword "Biophysics Theory"
Now showing items 1-4 of 4
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Epigenetic Landscapes Explain Partially Reprogrammed Cells and Identify Key Reprogramming Genes
(Public Library of Science, 2014)A common metaphor for describing development is a rugged “epigenetic landscape” where cell fates are represented as attracting valleys resulting from a complex regulatory network. Here, we introduce a framework for explicitly ... -
A Linear Framework for Time-Scale Separation in Nonlinear Biochemical Systems
(Public Library of Science, 2012)Cellular physiology is implemented by formidably complex biochemical systems with highly nonlinear dynamics, presenting a challenge for both experiment and theory. Time-scale separation has been one of the few theoretical ... -
Point Charges Optimally Placed to Represent the Multipole Expansion of Charge Distributions
(Public Library of Science, 2013)We propose an approach for approximating electrostatic charge distributions with a small number of point charges to optimally represent the original charge distribution. By construction, the proposed optimal point charge ... -
Theory on the Coupled Stochastic Dynamics of Transcription and Splice-Site Recognition
(Public Library of Science, 2012)Eukaryotic genes are typically split into exons that need to be spliced together to form the mature mRNA. The splicing process depends on the dynamics and interactions among transcription by the RNA polymerase II complex ...