Browsing Harvard Medical School by Keyword "Breast cancer"

Now showing items 1-20 of 21

    • Access to care issues adversely affect breast cancer patients in Mexico: oncologists’ perspective 

      Chavarri-Guerra, Yanin; St Louis, Jessica; Liedke, Pedro ER; Symecko, Heather; Villarreal-Garza, Cynthia; Mohar, Alejandro; Finkelstein, Dianne M; Goss, Paul E (BioMed Central, 2014)
      Background: Despite recently implemented access to care programs, Mexican breast cancer (BC) mortality rates remain substantially above those in the US. We conducted a survey among Mexican Oncologists to determine whether ...

    • Analysis of growth factor signaling in genetically diverse breast cancer lines 

      Niepel, Mario; Hafner, Marc; Pace, Emily A; Chung, Mirra; Chai, Diana H; Zhou, Lili; Muhlich, Jeremy L; Schoeberl, Birgit; Sorger, Peter K (BioMed Central, 2014)
      Background: Soluble growth factors present in the microenvironment play a major role in tumor development, invasion, metastasis, and responsiveness to targeted therapies. While the biochemistry of growth factor-dependent ...

    • Assessing the acceptability and feasibility of encounter decision aids for early stage breast cancer targeted at underserved patients 

      Alam, Shama; Elwyn, Glyn; Percac-Lima, Sanja; Grande, Stuart; Durand, Marie-Anne (BioMed Central, 2016)
      Background: Women of low socioeconomic status (SES) diagnosed with early stage breast cancer are less likely to be involved in treatment decisions. They tend to report higher decisional regret and poorer communication. ...

    • Association of microRNAs and pathologic response to preoperative chemotherapy in triple negative breast cancer: preliminary report 

      Kolacinska, Agnieszka; Morawiec, Jan; Fendler, Wojciech; Malachowska, Beata; Morawiec, Zbigniew; Szemraj, Janusz; Pawlowska, Zofia; Chowdhury, Dipanjan; Choi, Young Eun; Kubiak, Robert; Pakula, Lukasz; Zawlik, Izabela (Springer Netherlands, 2014)
      Triple negative breast cancer (TNBC) has caught the attention of oncologists worldwide because of poor prognosis and paucity of targeted therapies. Gene pathways have been widely studied, but less is known about epigenetic ...

    • Data on Medicare eligibility and cancer screening utilization 

      Meyer, Christian P.; Allard, Christopher B.; Sammon, Jesse D.; Hanske, Julian; McNabb-Baltar, Julia; Goldberg, Joel E.; Reznor, Gally; Lipsitz, Stuart R.; Choueiri, Toni K.; Nguyen, Paul L.; Weissman, Joel S.; Trinh, Quoc-Dien (Elsevier, 2016)
      Health insurance is associated with increased utilization of cancer screening services. Data on breast, prostate and colorectal cancer screening were abstracted from the 2012 Behavioral Risk Factor and Surveillance System. ...

    • Deep targeted sequencing of 12 breast cancer susceptibility regions in 4611 women across four different ethnicities 

      Lindström, Sara; Ablorh, Akweley; Chapman, Brad; Gusev, Alexander; Chen, Gary; Turman, Constance; Eliassen, A. Heather; Price, Alkes L.; Henderson, Brian E.; Le Marchand, Loic; Hofmann, Oliver; Haiman, Christopher A.; Kraft, Peter (BioMed Central, 2016)
      Background: Although genome-wide association studies (GWASs) have identified thousands of disease susceptibility regions, the underlying causal mechanism in these regions is not fully known. It is likely that the GWAS ...

    • Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling 

      Bancovik, Jasna; Moreira, Dayson F; Carrasco, Daniel; Yao, Jun; Porter, Dale; Moura, Ricardo; Camargo, Anamaria; Fontes-Oliveira, Cibely C; Malpartida, Miguel G; Carambula, Silvia; Vannier, Edouard; Strauss, Bryan E; Wakamatsu, Alda; Alves, Venancio AF; Logullo, Angela F; Soares, Fernando A; Polyak, Kornelia; Belizário, José E (BioMed Central, 2015)
      Background: We previously identified dermicidin (DCD), which encodes a growth and survival factor, as a gene amplified and overexpressed in a subset of breast tumors. Patients with DCD-positive breast cancer have worse ...

    • Does veteran status mitigate racial and ethnic disparities in cancer screening? A comprehensive analysis of Prostate, Colorectal, Breast, and Cervical cancer screening among veterans and non-veterans using the United States Behavioral Risk Factor Surveillance System. 

      Alkhatib, Khalid Yusuf (2022-05-10)
      In the United States, racial/ethnic minorities have been associated with worse outcomes for many chronic diseases, ranging from cardiovascular conditions to cancer. Indeed, the cancer literature is replete with such findings ...

    • Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype 

      Hefti, Marco M; Hu, Rong; Knoblauch, Nicholas W; Collins, Laura C; Haibe-Kains, Benjamin; Tamimi, Rulla M; Beck, Andrew H (BioMed Central, 2013)
      Introduction: Estrogen receptor (ER) and progesterone receptor (PR) testing are performed in the evaluation of breast cancer. While the clinical utility of ER as a predictive biomarker to identify patients likely to benefit ...

    • Extranuclear ERα is associated with regression of T47D PKCα-overexpressing, tamoxifen-resistant breast cancer 

      Perez White, Bethany; Molloy, Mary Ellen; Zhao, Huiping; Zhang, Yiyun; Tonetti, Debra A (BioMed Central, 2013)
      Background: Prior to the introduction of tamoxifen, high dose estradiol was used to treat breast cancer patients with similar efficacy as tamoxifen, albeit with some undesirable side effects. There is renewed interest to ...

    • Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems 

      Burton, Anya; Byrnes, Graham; Stone, Jennifer; Tamimi, Rulla M.; Heine, John; Vachon, Celine; Ozmen, Vahit; Pereira, Ana; Garmendia, Maria Luisa; Scott, Christopher; Hipwell, John H.; Dickens, Caroline; Schüz, Joachim; Aribal, Mustafa Erkin; Bertrand, Kimberly; Kwong, Ava; Giles, Graham G.; Hopper, John; Pérez Gómez, Beatriz; Pollán, Marina; Teo, Soo-Hwang; Mariapun, Shivaani; Taib, Nur Aishah Mohd; Lajous, Martín; Lopez-Riduara, Ruy; Rice, Megan; Romieu, Isabelle; Flugelman, Anath Arzee; Ursin, Giske; Qureshi, Samera; Ma, Huiyan; Lee, Eunjung; Sirous, Reza; Sirous, Mehri; Lee, Jong Won; Kim, Jisun; Salem, Dorria; Kamal, Rasha; Hartman, Mikael; Miao, Hui; Chia, Kee-Seng; Nagata, Chisato; Vinayak, Sudhir; Ndumia, Rose; van Gils, Carla H.; Wanders, Johanna O. P.; Peplonska, Beata; Bukowska, Agnieszka; Allen, Steve; Vinnicombe, Sarah; Moss, Sue; Chiarelli, Anna M.; Linton, Linda; Maskarinec, Gertraud; Yaffe, Martin J.; Boyd, Norman F.; dos-Santos-Silva, Isabel; McCormack, Valerie A. (BioMed Central, 2016)
      Background: Inter-women and intra-women comparisons of mammographic density (MD) are needed in research, clinical and screening applications; however, MD measurements are influenced by mammography modality (screen film/digital) ...

    • Measuring decision quality: psychometric evaluation of a new instrument for breast cancer chemotherapy 

      Lee, Clara N; Wetschler, Matthew H; Chang, Yuchiao; Belkora, Jeffrey K; Moy, Beverly; Partridge, Ann; Sepucha, Karen R (BioMed Central, 2014)
      Background: Women diagnosed with early stage (I or II) breast cancer face a highly challenging decision – whether or not to undergo adjuvant chemotherapy. We developed a decision quality instrument for chemotherapy for ...

    • miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer 

      Corcoran, Claire; Rani, Sweta; Breslin, Susan; Gogarty, Martina; Ghobrial, Irene M; Crown, John; O’Driscoll, Lorraine (BioMed Central, 2014)
      Background: While the treatment of HER2 over-expressing breast cancer with recent HER-targeted drugs has been highly effective for some patients, primary (also known as innate) or acquired resistance limits the success of ...

    • No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer 

      Hollestelle, Antoinette; van der Baan, Frederieke H.; Berchuck, Andrew; Johnatty, Sharon E.; Aben, Katja K.; Agnarsson, Bjarni A.; Aittomäki, Kristiina; Alducci, Elisa; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Antoniou, Antonis C.; Apicella, Carmel; Arndt, Volker; Arnold, Norbert; Arun, Banu K.; Arver, Brita; Ashworth, Alan; Baglietto, Laura; Balleine, Rosemary; Bandera, Elisa V.; Barrowdale, Daniel; Bean, Yukie T.; Beckmann, Lars; Beckmann, Matthias W.; Benitez, Javier; Berger, Andreas; Berger, Raanan; Beuselinck, Benoit; Bisogna, Maria; Bjorge, Line; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Anders; Bojesen, Stig E.; Bolla, Manjeet K.; Bonanni, Bernardo; Brand, Judith S.; Brauch, Hiltrud; Brenner, Hermann; Brinton, Louise; Brooks-Wilson, Angela; Bruinsma, Fiona; Brunet, Joan; Brüning, Thomas; Budzilowska, Agnieszka; Bunker, Clareann H.; Burwinkel, Barbara; Butzow, Ralf; Buys, Saundra S.; Caligo, Maria A.; Campbell, Ian; Carter, Jonathan; Chang-Claude, Jenny; Chanock, Stephen J.; Claes, Kathleen B.M.; Collée, J. Margriet; Cook, Linda S.; Couch, Fergus J.; Cox, Angela; Cramer, Daniel William; Cross, Simon S.; Cunningham, Julie M.; Cybulski, Cezary; Czene, Kamila; Damiola, Francesca; Dansonka-Mieszkowska, Agnieszka; Darabi, Hatef; de la Hoya, Miguel; deFazio, Anna; Dennis, Joseph; Devilee, Peter; Dicks, Ed M.; Diez, Orland; Doherty, Jennifer A.; Domchek, Susan M.; Dorfling, Cecilia M.; Dörk, Thilo; Silva, Isabel Dos Santos; du Bois, Andreas; Dumont, Martine; Dunning, Alison M.; Duran, Mercedes; Easton, Douglas F.; Eccles, Diana; Edwards, Robert P.; Ehrencrona, Hans; Ejlertsen, Bent; Ekici, Arif B.; Ellis, Steve D.; Engel, Christoph; Eriksson, Mikael; Fasching, Peter A.; Feliubadalo, Lidia; Figueroa, Jonine; Flesch-Janys, Dieter; Fletcher, Olivia; Fontaine, Annette; Fortuzzi, Stefano; Fostira, Florentia; Fridley, Brooke L.; Friebel, Tara; Friedman, Eitan; Friel, Grace; Frost, Debra; Garber, Judy Ellen; García-Closas, Montserrat; Gayther, Simon A.; Gentry-Maharaj, Aleksandra; Gerdes, Anne-Marie; Giles, Graham G.; Glasspool, Rosalind; Glendon, Gord; Godwin, Andrew K.; Goodman, Marc T.; Gore, Martin; Greene, Mark H.; Grip, Mervi; Gronwald, Jacek; Gschwantler Kaulich, Daphne; Guénel, Pascal; Guzman, Starr R.; Haeberle, Lothar; Haiman, Christopher A.; Hall, Per; Halverson, Sandra L.; Hamann, Ute; Hansen, Thomas V.O.; Harter, Philipp; Hartikainen, Jaana M.; Healey, Sue; Hein, Alexander; Heitz, Florian; Henderson, Brian E.; Herzog, Josef; T Hildebrandt, Michelle A.; Høgdall, Claus K.; Høgdall, Estrid; Hogervorst, Frans B.L.; Hopper, John L.; Humphreys, Keith; Huzarski, Tomasz; Imyanitov, Evgeny N.; Isaacs, Claudine; Jakubowska, Anna; Janavicius, Ramunas; Jaworska, Katarzyna; Jensen, Allan; Jensen, Uffe Birk; Johnson, Nichola; Jukkola-Vuorinen, Arja; Kabisch, Maria; Karlan, Beth Y.; Kataja, Vesa; Kauff, Noah; Kelemen, Linda E.; Kerin, Michael J.; Kiemeney, Lambertus A.; Kjaer, Susanne K.; Knight, Julia A.; Knol-Bout, Jacoba P.; Konstantopoulou, Irene; Kosma, Veli-Matti; Krakstad, Camilla; Kristensen, Vessela; Kuchenbaecker, Karoline B.; Kupryjanczyk, Jolanta; Laitman, Yael; Lambrechts, Diether; Lambrechts, Sandrina; Larson, Melissa C.; Lasa, Adriana; Laurent-Puig, Pierre; Lazaro, Conxi; Le, Nhu D.; Le Marchand, Loic; Leminen, Arto; Lester, Jenny; Levine, Douglas A.; Li, Jingmei; Liang, Dong; Lindblom, Annika; Lindor, Noralane; Lissowska, Jolanta; Long, Jirong; Lu, Karen H.; Lubinski, Jan; Lundvall, Lene; Lurie, Galina; Mai, Phuong L.; Mannermaa, Arto; Margolin, Sara; Mariette, Frederique; Marme, Frederik; Martens, John W.M.; Massuger, Leon F.A.G.; Maugard, Christine; Mazoyer, Sylvie; McGuffog, Lesley; McGuire, Valerie; McLean, Catriona; McNeish, Iain; Meindl, Alfons; Menegaux, Florence; Menéndez, Primitiva; Menkiszak, Janusz; Menon, Usha; Mensenkamp, Arjen R.; Miller, Nicola; Milne, Roger L.; Modugno, Francesmary; Montagna, Marco; Moysich, Kirsten B.; Müller, Heiko; Mulligan, Anna Marie; Muranen, Taru A.; Narod, Steven A.; Nathanson, Katherine L.; Ness, Roberta B.; Neuhausen, Susan L.; Nevanlinna, Heli; Neven, Patrick; Nielsen, Finn C.; Nielsen, Sune F.; Nordestgaard, Børge G.; Nussbaum, Robert L.; Odunsi, Kunle; Offit, Kenneth; Olah, Edith; Olopade, Olufunmilayo I.; Olson, Janet E.; Olson, Sara H.; Oosterwijk, Jan C.; Orlow, Irene; Orr, Nick; Orsulic, Sandra; Osorio, Ana; Ottini, Laura; Paul, James; Pearce, Celeste L.; Pedersen, Inge Sokilde; Peissel, Bernard; Pejovic, Tanja; Pelttari, Liisa M.; Perkins, Jo; Permuth-Wey, Jenny; Peterlongo, Paolo; Peto, Julian; Phelan, Catherine M.; Phillips, Kelly-Anne; Piedmonte, Marion; Pike, Malcolm C.; Platte, Radka; Plisiecka-Halasa, Joanna; Poole, Elizabeth M.; Poppe, Bruce; Pylkäs, Katri; Radice, Paolo; Ramus, Susan J.; Rebbeck, Timothy R; Reed, Malcolm W.R.; Rennert, Gad; Risch, Harvey A.; Robson, Mark; Rodriguez, Gustavo C.; Romero, Atocha; Rossing, Mary Anne; Rothstein, Joseph H.; Rudolph, Anja; Runnebaum, Ingo; Salani, Ritu; Salvesen, Helga B.; Sawyer, Elinor J.; Schildkraut, Joellen M.; Schmidt, Marjanka K.; Schmutzler, Rita K.; Schneeweiss, Andreas; Schoemaker, Minouk J.; Schrauder, Michael G.; Schumacher, Fredrick; Schwaab, Ira; Scuvera, Giulietta; Sellers, Thomas A.; Severi, Gianluca; Seynaeve, Caroline M.; Shah, Mitul; Shrubsole, Martha; Siddiqui, Nadeem; Sieh, Weiva; Simard, Jacques; Singer, Christian F.; Sinilnikova, Olga M.; Smeets, Dominiek; Sohn, Christof; Soller, Maria; Song, Honglin; Soucy, Penny; Southey, Melissa C.; Stegmaier, Christa; Stoppa-Lyonnet, Dominique; Sucheston, Lara; Swerdlow, Anthony; Tangen, Ingvild L.; Tea, Muy-Kheng; Teixeira, Manuel R.; Terry, Kathryn Lynne; Terry, Mary Beth; Thomassen, Mads; Thompson, Pamela J.; Tihomirova, Laima; Tischkowitz, Marc; Toland, Amanda Ewart; Tollenaar, Rob A.E.M.; Tomlinson, Ian; Torres, Diana; Truong, Thérèse; Tsimiklis, Helen; Tung, Nadine Muskatel; Tworoger, Shelley Slate; Tyrer, Jonathan P.; Vachon, Celine M.; Van, Laura J.; van Altena, Anne M.; Van Asperen, C.J.; van den Berg, David; van den Ouweland, Ans M.W.; van Doorn, Helena C.; Van Nieuwenhuysen, Els; van Rensburg, Elizabeth J.; Vergote, Ignace; Verhoef, Senno; Vierkant, Robert A.; Vijai, Joseph; Vitonis, Allison F.; von Wachenfeldt, Anna; Walsh, Christine; Wang, Qin; Wang-Gohrke, Shan; Wappenschmidt, Barbara; Weischer, Maren; Weitzel, Jeffrey N.; Weltens, Caroline; Wentzensen, Nicolas; Whittemore, Alice S.; Wilkens, Lynne R.; Winqvist, Robert; Wu, Anna H.; Wu, Xifeng; Yang, Hannah P.; Zaffaroni, Daniela; Pilar Zamora, M.; Zheng, Wei; Ziogas, Argyrios; Chenevix-Trench, Georgia; Pharoah, Paul D.P.; Rookus, Matti A.; Hooning, Maartje J.; Goode, Ellen L. (Elsevier BV, 2016)
      OBJECTIVE: Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer ...

    • The Nuclear Matrix Protein, NRP/B, Acts as a Transcriptional Repressor of E2F-mediated Transcriptional Activity 

      Choi, Jina; Yang, Eun Sung; Cha, Kiweon; Whang, John; Choi, Woo-Jung; Avraham, Shalom; Kim, Tae-Aug (Korean Society of Cancer Prevention, 2014)
      Background: NRP/B, a family member of the BTB/Kelch repeat proteins, is implicated in neuronal and cancer development, as well as the regulation of oxidative stress responses in breast and brain cancer. Our previous studies ...

    • The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway 

      Sun, Ye; Kaneko, Satoshi; Li, Xiaokun; Li, Xue (2014)
      Eya1 is a conserved critical regulator of organ-specific stem cells. Ectopic Eya1 activities, however, promote transformation of mammary epithelial cells. Signals that instigate Eya1 oncogenic activities remain to be ...

    • Proton radiotherapy for chest wall and regional lymphatic radiation; dose comparisons and treatment delivery 

      MacDonald, Shannon Michelle; Jimenez, Rachel Beth; Paetzold, Peter; Adams, Judith; Beatty, Jonathan; Delaney, Thomas F.; Kooy, Hanne M.; Taghian, Alphonse G.; Lu, Hsiao-ming (BioMed Central, 2013)
      Purpose The delivery of post-mastectomy radiation therapy (PMRT) can be challenging for patients with left sided breast cancer that have undergone mastectomy. This study investigates the use of protons for PMRT in selected ...

    • Study protocol for Young & Strong: a cluster randomized design to increase attention to unique issues faced by young women with newly diagnosed breast cancer 

      Greaney, Mary L; Sprunck-Harrild, Kim; Ruddy, Kathryn J; Ligibel, Jennifer; Barry, William T; Baker, Emily; Meyer, Meghan; Emmons, Karen M; Partridge, Ann H (BioMed Central, 2015)
      Background: Each year, approximately 11% of women diagnosed with breast cancer in the United States are 45 years of age or younger. These women have concerns specific to or accentuated by their age, including fertility-related ...

    • Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer 

      Chandler, Paige; Kochupurakkal, Bose S.; Alam, Samina; Richardson, Andrea L.; Soybel, David I.; Kelleher, Shannon L. (BioMed Central, 2016)
      Background: Zinc (Zn) hyper-accumulates in breast tumors and malignant cell lines compared to normal mammary epithelium. The mechanisms responsible for Zn accumulation and the consequence of Zn dysregulation are poorly ...

    • Systemic treatment in breast cancer: a primer for radiologists 

      Michaels, Aya Y.; Keraliya, Abhishek R.; Tirumani, Sree Harsha; Shinagare, Atul B.; Ramaiya, Nikhil H. (Springer Berlin Heidelberg, 2015)
      Abstract Cytotoxic chemotherapy, hormonal therapy and molecular targeted therapy are the three major classes of drugs used to treat breast cancer. Imaging modalities such as computed tomography (CT), magnetic resonance ...