Browsing Harvard Medical School by Keyword "Bumetanide"
Now showing items 1-2 of 2
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Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures
(BlackWell Publishing Ltd, 2014)Seizures are a common manifestation of acute neurologic insults in neonates and are often resistant to the standard antiepileptic drugs that are efficacious in children and adults. The paucity of evidence-based treatment ... -
WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration
(BioMed Central, 2014)Background: The bumetanide (BMT)-sensitive Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) maintains cell volume homeostasis by increasing intracellular K+ and Cl- content via regulatory volume increase (RVI). Expression levels ...