Browsing Harvard Medical School by Keyword "CD4"
Now showing items 1-9 of 9
-
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes
(BioMed Central, 2013)Background: The highly genetically diverse HIV-1 group M subtypes may differ in their biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a comprehensive inter-subtype comparison ... -
CD4+ and viral load outcomes of antiretroviral therapy switch strategies after virologic failure of combination antiretroviral therapy in perinatally HIV-infected youth in the United States
(Lippincott Williams & Wilkins, 2015)Objective: This study compared 12-month CD4+ and viral load outcomes in HIV-infected children and adolescents with virological failure, managed with four treatment switch strategies. Design: This observational study included ... -
Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins
(Elsevier, 2016)Human immunodeficiency virus type 1 (HIV-1) has evolved a sophisticated strategy to conceal conserved epitopes of its envelope glycoproteins (Env) recognized by antibody-dependent cellular cytotoxicity (ADCC)-mediating ... -
Etiology and risk factors associated with a pruritic papular eruption in people living with HIV in India
(International AIDS Society, 2013)Introduction: Papulopruritic eruption (PPE) occurs in people living with HIV in India. Understanding the risk factors associated with this disease may help decrease the prevalence of PPE. Methods: This study was a case-control ... -
Metallothionein regulates intracellular zinc signaling during CD4+ T cell activation
(BioMed Central, 2016)Background: The ultra-low redox potential and zinc binding properties of the intracellular pool of mammalian metallothioneins (MT) suggest a role for MT in the transduction of redox signals into intracellular zinc signals. ... -
The Non-Obese Diabetic Mouse Strain as a Model to Study CD8+ T Cell Function in Relapsing and Progressive Multiple Sclerosis
(Frontiers Media S.A., 2015)Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack on central nervous system (CNS) myelin. Although CD4+ T cell function in MS pathology has been extensively studied, there is also ... -
Predictors of suboptimal CD4 response among women achieving virologic suppression in a randomized antiretroviral treatment trial, Africa
(BioMed Central, 2014)Background: A subset of HIV-1 infected patients starting highly active antiretroviral treatment (HAART) experience suboptimal CD4 response (SCR) despite virologic suppression. We studied the rate of and risk factors for ... -
Response to hepatitis B vaccination among HIV-infected adults in Vietnam
(Mediscript Ltd, 2016)Abstract Objectives: We sought to determine the rate of response to hepatitis B (HBV) vaccination among HIV-infected adults in Vietnam. Methods: We retrospectively abstracted data from a cohort of HIV-infected adults who ... -
Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity
(Elsevier, 2015)Human immunodeficiency virus type 1 (HIV-1) infection causes a progressive depletion of CD4 + T cells. Despite its importance for HIV-1 pathogenesis, the precise mechanisms underlying CD4 + T-cell depletion remain incompletely ...