Browsing Harvard Medical School by Keyword "CD8"

Now showing items 1-6 of 6

    • Antigen Cross-Presentation of Immune Complexes 

      Platzer, Barbara; Stout, Madeleine; Fiebiger, Edda (Frontiers Media S.A., 2014)
      The ability of dendritic cells (DCs) to cross-present tumor antigens has long been a focus of interest to physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A ...

    • Generation and Regulation of CD8+ Regulatory T Cells 

      Lu, Linrong; Cantor, Harvey (Nature Publishing Group, 2008)
      Research into the suppressive activity of CD4+FoxP3+ T regulatory cells (Treg) has defined a sublineage of CD4+ cells that contribute to self-tolerance and resistance to autoimmune disease. Much less attention has been ...

    • HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults 

      Matthews, Philippa C.; Carlson, Jonathan M.; Beloukas, Apostolos; Malik, Amna; Jooste, Pieter; Ogwu, Anthony; Shapiro, Roger; Riddell, Lynn; Chen, Fabian; Luzzi, Graz; Jesuthasan, Gerald; Jeffery, Katie; Jojic, Nebojsa; Ndung'u, Thumbi; Carrington, Mary; Goulder, Philip J. R.; Geretti, Anna Maria; Klenerman, Paul (Oxford University Press, 2015)
      Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well ...

    • HP-1γ Controls High-Affinity Antibody Response to T-Dependent Antigens 

      Ha, Ngoc; Pham, Duc-Hung; Shahsafaei, Aliakbar; Naruse, Chie; Asano, Masahide; Thai, To-Ha (Frontiers Media S.A., 2014)
      In vitro observations suggest a role for the mouse heterochromatin protein 1γ (HP-1γ) in the immune system. However, it has not been shown if and how HP-1γ contributes to immunity in vivo. Here we show that in mice, HP-1γ ...

    • Lessons to be Learned from Natural Control of HIV – Future Directions, Therapeutic, and Preventive Implications 

      Shasha, David; Walker, Bruce D. (Frontiers Media S.A., 2013)
      Accumulating data generated from persons who naturally control HIV without the need for antiretroviral treatment has led to significant insights into the possible mechanisms of durable control of AIDS virus infection. At ...

    • The Non-Obese Diabetic Mouse Strain as a Model to Study CD8+ T Cell Function in Relapsing and Progressive Multiple Sclerosis 

      Ignatius Arokia Doss, Prenitha Mercy; Roy, Andrée-Pascale; Wang, AiLi; Anderson, Ana Carrizosa; Rangachari, Manu (Frontiers Media S.A., 2015)
      Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack on central nervous system (CNS) myelin. Although CD4+ T cell function in MS pathology has been extensively studied, there is also ...