Browsing Harvard Medical School by Keyword "Chaperone Proteins"

Now showing items 1-4 of 4

    • Comprehensive Definition of the SigH Regulon of Mycobacterium tuberculosis Reveals Transcriptional Control of Diverse Stress Responses 

      Sharp, Jared D.; Singh, Atul K.; Park, Sang Tae; Lyubetskaya, Anna; Peterson, Matthew W.; Gomes, Antonio L. C.; Potluri, Lakshmi-Prasad; Raman, Sahadevan; Galagan, James E.; Husson, Robert N. (Public Library of Science, 2016)
      Expression of SigH, one of 12 Mycobacterium tuberculosis alternative sigma factors, is induced by heat, oxidative and nitric oxide stresses. SigH activation has been shown to increase expression of several genes, including ...

    • Improved Cell-Free RNA and Protein Synthesis System 

      Li, Jun; Gu, Liangcai; Aach, John; Church, George M. (Public Library of Science, 2014)
      Cell-free RNA and protein synthesis (CFPS) is becoming increasingly used for protein production as yields increase and costs decrease. Advances in reconstituted CFPS systems such as the Protein synthesis Using Recombinant ...

    • Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics 

      Swearingen, Kristian E.; Lindner, Scott E.; Shi, Lirong; Shears, Melanie J.; Harupa, Anke; Hopp, Christine S.; Vaughan, Ashley M.; Springer, Timothy A.; Moritz, Robert L.; Kappe, Stefan H. I.; Sinnis, Photini (Public Library of Science, 2016)
      Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to developing a malaria vaccine ...

    • NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies 

      Ali, Yousuf O.; Allen, Hunter M.; Yu, Lei; Li-Kroeger, David; Bakhshizadehmahmoudi, Dena; Hatcher, Asante; McCabe, Cristin; Xu, Jishu; Bjorklund, Nicole; Taglialatela, Giulio; Bennett, David A.; De Jager, Philip L.; Shulman, Joshua M.; Bellen, Hugo J.; Lu, Hui-Chen (Public Library of Science, 2016)
      Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurodegeneration. Here, we show that brain nmnat2 mRNA levels correlate positively with global cognitive ...