Browsing Harvard Medical School by Keyword "Chronic Kidney Disease"

Now showing items 1-16 of 16

    • The Association between Individual and Combined Components of Metabolic Syndrome and Chronic Kidney Disease among African Americans: The Jackson Heart Study 

      Mendy, Vincent L.; Azevedo, Mario J.; Sarpong, Daniel F.; Rosas, Sylvia E.; Ekundayo, Olugbemiga T.; Sung, Jung Hye; Bhuiyan, Azad R.; Jenkins, Brenda C.; Addison, Clifton (Public Library of Science, 2014)
      Introduction: Approximately 26.3 million people in the United States have chronic kidney disease and many more are at risk of developing the condition. The association between specific metabolic syndrome components and ...

    • Association of Estimated Glomerular Filtration Rate and Urinary Uromodulin Concentrations with Rare Variants Identified by UMOD Gene Region Sequencing 

      Köttgen, Anna; Yang, Qiong; Shimmin, Lawrence C.; Tin, Adrienne; Schaeffer, Céline; Coresh, Josef; Liu, Xuan; Rampoldi, Luca; Hwang, Shih-Jen; Boerwinkle, Eric; Hixson, James E.; Kao, W.H. Linda; Fox, Caroline (Public Library of Science, 2012)
      Background: Recent genome-wide association studies (GWAS) have identified common variants in the UMOD region associated with kidney function and disease in the general population. To identify novel rare variants as well ...

    • The Association of Systemic Microvascular Changes with Lung Function and Lung Density: A Cross-Sectional Study 

      Harris, Bianca; Klein, Ronald; Jerosch-Herold, Michael; Hoffman, Eric A.; Ahmed, Firas S.; Klein, Barbara E. K.; Wong, Tien Y.; Lima, Joao A. C.; Cotch, Mary Frances; Barr, R. Graham; Jacobs, David R., Jr. (Public Library of Science, 2012)
      Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We ...

    • Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing 

      Feng, Di; Steinke, Julia M.; Krishnan, Ramaswamy; Birrane, Gabriel; Pollak, Martin R. (Public Library of Science, 2016)
      Genetic testing in the clinic and research lab is becoming more routinely used to identify rare genetic variants. However, attributing these rare variants as the cause of disease in an individual patient remains challenging. ...

    • The Gap between Estimated Incidence of End-Stage Renal Disease and Use of Therapy 

      Anand, Shuchi; Bitton, Asaf; Gaziano, Thomas (Public Library of Science, 2013)
      Background: Relatively few data exist on the burden of end-stage renal disease (ESRD) and use of renal replacement therapy (RRT)–a life-saving therapy–in developing regions. No study has quantified the proportion of patients ...

    • Hypokalemia, Its Contributing Factors and Renal Outcomes in Patients with Chronic Kidney Disease 

      Wang, Hsiao-Han; Hung, Chi-Chih; Hwang, Daw-Yang; Kuo, Mei-Chuan; Chiu, Yi-Wen; Chang, Jer-Ming; Tsai, Jer-Chia; Hwang, Shang-Jyh; Seifter, Julian L.; Chen, Hung-Chun (Public Library of Science, 2013)
      Background: In the chronic kidney disease (CKD) population, the impact of serum potassium (sK) on renal outcomes has been controversial. Moreover, the reasons for the potential prognostic value of hypokalemia have not been ...

    • Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study 

      Amdur, Richard L.; Mukherjee, Monica; Go, Alan; Barrows, Ian R.; Ramezani, Ali; Shoji, Jun; Reilly, Muredach P.; Gnanaraj, Joseph; Deo, Raj; Roas, Sylvia; Keane, Martin; Master, Steve; Teal, Valerie; Soliman, Elsayed Z.; Yang, Peter; Feldman, Harold; Kusek, John W.; Tracy, Cynthia M.; Raj, Dominic S. (Public Library of Science, 2016)
      Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with chronic kidney disease (CKD). In this study, we examined the association between inflammation and AF in 3,762 adults with CKD, enrolled in ...

    • Nephronophthisis-Associated CEP164 Regulates Cell Cycle Progression, Apoptosis and Epithelial-to-Mesenchymal Transition 

      Slaats, Gisela G.; Ghosh, Amiya K.; Falke, Lucas L.; Le Corre, Stéphanie; Shaltiel, Indra A.; van de Hoek, Glenn; Klasson, Timothy D.; Stokman, Marijn F.; Logister, Ive; Verhaar, Marianne C.; Goldschmeding, Roel; Nguyen, Tri Q.; Drummond, Iain A.; Hildebrandt, Friedhelm; Giles, Rachel H. (Public Library of Science, 2014)
      We recently reported that centrosomal protein 164 (CEP164) regulates both cilia and the DNA damage response in the autosomal recessive polycystic kidney disease nephronophthisis. Here we examine the functional role of ...

    • New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes 

      Sandholm, Niina; Salem, Rany M.; McKnight, Amy Jayne; Brennan, Eoin P.; Forsblom, Carol; Isakova, Tamara; McKay, Gareth J.; Williams, Winfred Woodrow; Sadlier, Denise M.; Mäkinen, Ville-Petteri; Swan, Elizabeth J.; Palmer, Cameron Douglas; Boright, Andrew P.; Ahlqvist, Emma; Deshmukh, Harshal A.; Keller, Benjamin J.; Huang, Huateng; Ahola, Aila J.; Fagerholm, Emma; Gordin, Daniel; Harjutsalo, Valma; He, Bing; Heikkilä, Outi; Hietala, Kustaa; Kytö, Janne; Lahermo, Päivi; Lehto, Markku; Lithovius, Raija; Österholm, Anne-May; Parkkonen, Maija; Pitkäniemi, Janne; Rosengård-Bärlund, Milla; Saraheimo, Markku; Sarti, Cinzia; Söderlund, Jenny; Soro-Paavonen, Aino; Syreeni, Anna; Thorn, Lena M.; Tikkanen, Heikki; Tolonen, Nina; Tryggvason, Karl; Tuomilehto, Jaakko; Wadén, Johan; Gill, Geoffrey V.; Prior, Sarah Virginie; Guiducci, Candace; Mirel, Daniel B.; Taylor, Andrew; Hosseini, S. Mohsen; Parving, Hans-Henrik; Rossing, Peter; Tarnow, Lise; Ladenvall, Claes; Alhenc-Gelas, François; Lefebvre, Pierre; Rigalleau, Vincent; Roussel, Ronan; Tregouet, David-Alexandre; Maestroni, Anna; Maestroni, Silvia; Falhammar, Henrik; Gu, Tianwei; Möllsten, Anna; Cimponeriu, Danut; Ioana, Mihai; Mota, Maria; Mota, Eugen; Serafinceanu, Cristian; Stavarachi, Monica; Hanson, Robert L.; Nelson, Robert G.; Kretzler, Matthias; Colhoun, Helen M.; Panduru, Nicolae Mircea; Gu, Harvest F.; Brismar, Kerstin; Zerbini, Gianpaolo; Hadjadj, Samy; Marre, Michel; Groop, Leif; Lajer, Maria; Bull, Shelley B.; Waggott, Daryl; Paterson, Andrew D.; Savage, David A.; Bain, Stephen C.; Martin, Finian; Hirschhorn, Joel Naom; Godson, Catherine; Florez, Jose Carlos; Groop, Per-Henrik; Maxwell, Alexander P. (Public Library of Science, 2012)
      Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to ...

    • Risk of ESRD and All Cause Mortality in Type 2 Diabetes According to Circulating Levels of FGF-23 and TNFR1 

      Lee, Jung Eun; Gohda, Tomohito; Walker, William H.; Skupien, Jan; Smiles, Adam M.; Holak, Rita R.; Jeong, Jackson; McDonnell, Kevin P.; Krolewski, Andrzej Stefan; Niewczas, Monika Anna (Public Library of Science, 2013)
      Introduction: Recent studies demonstrated that circulating fibroblast growth factor (FGF)-23 was associated with risk of end stage renal disease (ESRD) and mortality. This study aims to examine whether the predictive effect ...

    • Serum Resistin and Kidney Function: A Family-Based Study in Non-Diabetic, Untreated Individuals 

      Menzaghi, Claudia; Salvemini, Lucia; Fini, Grazia; Mangiacotti, Davide; Di Paola, Rosa; Morini, Eleonora; Giorelli, Maddalena; De Bonis, Concetta; De Cosmo, Salvatore; Trischitta, Vincenzo; Thompson, Ryan Wesley; Doria, Alessandro (Public Library of Science, 2012)
      Background: High serum resistin levels have been associated with kidney dysfunction. Most of these studies have been carried out in individuals with severe kidney impairment, diabetes, cardiovascular disease and related ...

    • TLR-2/TLR-4 TREM-1 Signaling Pathway Is Dispensable in Inflammatory Myeloid Cells during Sterile Kidney Injury 

      Campanholle, Gabriela; Mittelsteadt, Kristen; Nakagawa, Shunsaku; Kobayashi, Akio; Lin, Shuei-Liong; Gharib, Sina A.; Heinecke, Jay W.; Hamerman, Jessica A.; Altemeier, William A.; Duffield, Jeremy S. (Public Library of Science, 2013)
      Inflammatory macrophages are abundant in kidney disease, stimulating repair, or driving chronic inflammation and fibrosis. Damage associated molecules (DAMPs), released from injured cells engage pattern recognition receptors ...

    • Transcriptional Patterns in Peritoneal Tissue of Encapsulating Peritoneal Sclerosis, a Complication of Chronic Peritoneal Dialysis 

      Reimold, Fabian Raoul; Braun, Niko; Zsengellér, Zsuzsanna K.; Stillman, Isaac Ely; Karumanchi, Subbian Ananth; Toka, Hakan; Latus, Joerg; Fritz, Peter; Biegger, Dagmar; Segerer, Stephan; Alscher, M. Dominik; Bhasin, Manoj; Alper, Seth Leo (Public Library of Science, 2013)
      Encapsulating peritoneal sclerosis (EPS) is a devastating complication of peritoneal dialysis (PD), characterized by marked inflammation and severe fibrosis of the peritoneum, and associated with high morbidity and mortality. ...

    • Transcriptome Analysis of Proximal Tubular Cells (HK-2) Exposed to Urines of Type 1 Diabetes Patients at Risk of Early Progressive Renal Function Decline 

      Wanic, Krzysztof; Krolewski, Bozena Krystyna; Ju, Wenjun; Placha, Grzegorz; Niewczas, Monika Anna; Walker, William; Warram, James H.; Kretzler, Matthias; Krolewski, Andrzej Stefan (Public Library of Science, 2013)
      Background: In patients with Type 1 Diabetes (T1D) who develop microalbuminuria, progressive decline in glomerular filtration rate (GFR) may be initiated by leakage into the urine of toxic proteins (txUPs). This study ...

    • Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Obstructive Sleep Apnea 

      Maski, Manish R.; Thomas, Robert J.; Karumanchi, S. Ananth; Parikh, Samir M. (Public Library of Science, 2016)
      Background: Obstructive sleep apnea (OSA) is a well-established risk factor for hypertension and cardiovascular morbidity and mortality. More recently, OSA has been implicated as an independent risk factor for chronic ...

    • Vitamin D Supplementation Enhances the Fixation of Titanium Implants in Chronic Kidney Disease Mice 

      Liu, Weiqing; Zhang, Shiwen; Zhao, Dan; Zou, Huawei; Sun, Ningyuan; Liang, Xing; Dard, Michel; Lanske, Beate; Yuan, Quan (Public Library of Science, 2014)
      Vitamin D (Vit D) deficiency is a common condition in chronic kidney disease (CKD) patients that negatively affects bone regeneration and fracture healing. Previous study has shown that timely healing of titanium implants ...