Browsing Harvard Medical School by Keyword "Chronic Obstructive Pulmonary Disease"

Now showing items 1-10 of 10

    • Altered Gene Expression in Blood and Sputum in COPD Frequent Exacerbators in the ECLIPSE Cohort 

      Singh, Dave; Fox, Steven M.; Tal-Singer, Ruth; Bates, Stewart; Riley, John H.; Celli, Bartolome (Public Library of Science, 2014)
      Patients with chronic obstructive pulmonary disease (COPD) who are defined as frequent exacerbators suffer with 2 or more exacerbations every year. The molecular mechanisms responsible for this phenotype are poorly understood. ...

    • Autoreactivity to Glucose Regulated Protein 78 Links Emphysema and Osteoporosis in Smokers 

      Bon, Jessica; Kahloon, Rehan; Zhang, Yingze; Xue, Jianmin; Fuhrman, Carl R.; Tan, Jiangning; Burger, Mathew; Kass, Daniel J.; Csizmadia, Eva; Otterbein, Leo; Chandra, Divay; Bhargava, Arpit; Pilewski, Joseph M.; Roodman, G. David; Sciurba, Frank C.; Duncan, Steven R. (Public Library of Science, 2014)
      Rationale: Emphysema and osteoporosis are epidemiologically associated diseases of cigarette smokers. The causal mechanism(s) linking these illnesses is unknown. We hypothesized autoimmune responses may be involved in both ...

    • Basal Gene Expression by Lung CD4+ T Cells in Chronic Obstructive Pulmonary Disease Identifies Independent Molecular Correlates of Airflow Obstruction and Emphysema Extent 

      Freeman, Christine M.; McCubbrey, Alexandra L.; Crudgington, Sean; Nelson, Joshua; Martinez, Fernando J.; Han, MeiLan K.; Washko, George R.; Chensue, Stephen W.; Arenberg, Douglas A.; Meldrum, Catherine A.; McCloskey, Lisa; Curtis, Jeffrey L. (Public Library of Science, 2014)
      Lung CD4+ T cells accumulate as chronic obstructive pulmonary disease (COPD) progresses, but their role in pathogenesis remains controversial. To address this controversy, we studied lung tissue from 53 subjects undergoing ...

    • Bipartite Community Structure of eQTLs 

      Platig, John; Castaldi, Peter J.; DeMeo, Dawn; Quackenbush, John (Public Library of Science, 2016)
      Genome Wide Association Studies (GWAS) and expression quantitative trait locus (eQTL) analyses have identified genetic associations with a wide range of human phenotypes. However, many of these variants have weak effects ...

    • Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD 

      Sun, Wei; Kechris, Katerina; Jacobson, Sean; Drummond, M. Bradley; Hawkins, Gregory A.; Yang, Jenny; Chen, Ting-huei; Quibrera, Pedro Miguel; Anderson, Wayne; Barr, R. Graham; Basta, Patricia V.; Bleecker, Eugene R.; Beaty, Terri; Casaburi, Richard; Castaldi, Peter; Cho, Michael H.; Comellas, Alejandro; Crapo, James D.; Criner, Gerard; Demeo, Dawn; Christenson, Stephanie A.; Couper, David J.; Curtis, Jeffrey L.; Doerschuk, Claire M.; Freeman, Christine M.; Gouskova, Natalia A.; Han, MeiLan K.; Hanania, Nicola A.; Hansel, Nadia N.; Hersh, Craig P.; Hoffman, Eric A.; Kaner, Robert J.; Kanner, Richard E.; Kleerup, Eric C.; Lutz, Sharon; Martinez, Fernando J.; Meyers, Deborah A.; Peters, Stephen P.; Regan, Elizabeth A.; Rennard, Stephen I.; Scholand, Mary Beth; Silverman, Edwin K.; Woodruff, Prescott G.; O’Neal, Wanda K.; Bowler, Russell P. (Public Library of Science, 2016)
      Implementing precision medicine for complex diseases such as chronic obstructive lung disease (COPD) will require extensive use of biomarkers and an in-depth understanding of how genetic, epigenetic, and environmental ...

    • Hemizygous Deletion on Chromosome 3p26.1 Is Associated with Heavy Smoking among African American Subjects in the COPDGene Study 

      Begum, Ferdouse; Ruczinski, Ingo; Hokanson, John E.; Lutz, Sharon M.; Parker, Margaret M.; Cho, Michael H.; Hetmanski, Jacqueline B.; Scharpf, Robert B.; Crapo, James D.; Silverman, Edwin K.; Beaty, Terri H. (Public Library of Science, 2016)
      Many well-powered genome-wide association studies have identified genetic determinants of self-reported smoking behaviors and measures of nicotine dependence, but most have not considered the role of structural variants, ...

    • Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012 

      Zein, Joe G.; Udeh, Belinda L.; Teague, W. Gerald; Koroukian, Siran M.; Schlitz, Nicholas K.; Bleecker, Eugene R.; Busse, William B.; Calhoun, William J.; Castro, Mario; Comhair, Suzy A.; Fitzpatrick, Anne M.; Israel, Elliot; Wenzel, Sally E.; Holguin, Fernando; Gaston, Benjamin M.; Erzurum, Serpil C. (Public Library of Science, 2016)
      Background: Worldwide, asthma is a leading cause of morbidity, mortality and economic burden, with significant gender and racial disparities. However, little attention has been given to the independent role of age on ...

    • Is COPD a Progressive Disease? A Long Term Bode Cohort Observation 

      de-Torres, Juan P.; Marín, Jose M.; Pinto-Plata, Víctor; Divo, Miguel; Sanchez-Salcedo, Pablo; Zagaceta, Jorge; Zulueta, Javier J.; Berto, Juan; Cabrera, Carlos; Celli, Bartolome R.; Casanova, Ciro (Public Library of Science, 2016)
      Background: The Global Initiative for Obstructive Lung Diseases (GOLD) defines COPD as a disease that is usually progressive. GOLD also provides a spirometric classification of airflow limitation. However, little is known ...

    • A Simplified Score to Quantify Comorbidity in COPD 

      Putcha, Nirupama; Puhan, Milo A.; Drummond, M. Bradley; Han, MeiLan K.; Regan, Elizabeth A.; Hanania, Nicola A.; Martinez, Carlos H.; Foreman, Marilyn; Bhatt, Surya P.; Make, Barry; Ramsdell, Joe; DeMeo, Dawn L.; Barr, R. Graham; Rennard, Stephen I.; Martinez, Fernando; Silverman, Edwin K.; Crapo, James; Wise, Robert A.; Hansel, Nadia N. (Public Library of Science, 2014)
      Importance Comorbidities are common in COPD, but quantifying their burden is difficult. Currently there is a COPD-specific comorbidity index to predict mortality and another to predict general quality of life. We sought ...

    • Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study 

      Dijkstra, Akkelies E.; Smolonska, Joanna; van den Berge, Maarten; Wijmenga, Ciska; Zanen, Pieter; Luinge, Marjan A.; Platteel, Mathieu; Lammers, Jan-Willem; Dahlback, Magnus; Tosh, Kerrie; Hiemstra, Pieter S.; Sterk, Peter J.; Spira, Avi; Vestbo, Jorgen; Nordestgaard, Borge G.; Benn, Marianne; Nielsen, Sune F.; Dahl, Morten; Verschuren, W. Monique; Picavet, H. Susan J.; Smit, Henriette A.; Owsijewitsch, Michael; Kauczor, Hans U.; de Koning, Harry J.; Nizankowska-Mogilnicka, Eva; Mejza, Filip; Nastalek, Pawel; van Diemen, Cleo C.; Cho, Michael H.; Silverman, Edwin K.; Crapo, James D.; Beaty, Terri H.; Lomas, David A.; Bakke, Per; Gulsvik, Amund; Bossé, Yohan; Obeidat, M. A.; Loth, Daan W.; Lahousse, Lies; Rivadeneira, Fernando; Uitterlinden, Andre G.; Hofman, Andre; Stricker, Bruno H.; Brusselle, Guy G.; van Duijn, Cornelia M.; Brouwer, Uilke; Koppelman, Gerard H.; Vonk, Judith M.; Nawijn, Martijn C.; Groen, Harry J. M.; Timens, Wim; Boezen, H. Marike; Postma, Dirkje S. (Public Library of Science, 2014)
      Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. ...