Browsing Harvard Medical School by Keyword "Computational Neuroscience"
Now showing items 1-16 of 16
-
An Approach to Localizing Corneal Pain Representation in Human Primary Somatosensory Cortex
(Public Library of Science, 2012)The cornea has been a focus of animal electrophysiological research for decades, but little is known regarding its cortical representation in the human brain. This study attempts to localize the somatotopic representation ... -
Characteristics and Predictive Value of Blood Transcriptome Signature in Males with Autism Spectrum Disorders
(Public Library of Science, 2012)Autism Spectrum Disorders (ASD) is a spectrum of highly heritable neurodevelopmental disorders in which known mutations contribute to disease risk in 20% of cases. Here, we report the results of the largest blood transcriptome ... -
Depth Sensitivity and Source-Detector Separations for Near Infrared Spectroscopy Based on the Colin27 Brain Template
(Public Library of Science, 2013)Understanding the spatial and depth sensitivity of non-invasive near-infrared spectroscopy (NIRS) measurements to brain tissue–i.e., near-infrared neuromonitoring (NIN) – is essential for designing experiments as well as ... -
Development of Antipsychotic Medications with Novel Mechanisms of Action Based on Computational Modeling of Hippocampal Neuropathology
(Public Library of Science, 2013)A large number of cellular level abnormalities have been identified in the hippocampus of schizophrenic subjects. Nonetheless, it remains uncertain how these pathologies interact at a system level to create clinical symptoms, ... -
Efficient Universal Computing Architectures for Decoding Neural Activity
(Public Library of Science, 2012)The ability to decode neural activity into meaningful control signals for prosthetic devices is critical to the development of clinically useful brain– machine interfaces (BMIs). Such systems require input from tens to ... -
Fractal Patterns of Neural Activity Exist within the Suprachiasmatic Nucleus and Require Extrinsic Network Interactions
(Public Library of Science, 2012)The mammalian central circadian pacemaker (the suprachiasmatic nucleus, SCN) contains thousands of neurons that are coupled through a complex network of interactions. In addition to the established role of the SCN in ... -
GABA\(_A\) Receptors Containing the \(\alpha\)2 Subunit Are Critical for Direction-Selective Inhibition in the Retina
(Public Library of Science, 2012)Far from being a simple sensor, the retina actively participates in processing visual signals. One of the best understood aspects of this processing is the detection of motion direction. Direction-selective (DS) retinal ... -
Network-Level Structural Abnormalities of Cerebral Cortex in Type 1 Diabetes Mellitus
(Public Library of Science, 2013)Type 1 diabetes mellitus (T1DM) usually begins in childhood and adolescence and causes lifelong damage to several major organs including the brain. Despite increasing evidence of T1DM-induced structural deficits in cortical ... -
Non-Invasive Brain-to-Brain Interface (BBI): Establishing Functional Links between Two Brains
(Public Library of Science, 2013)Transcranial focused ultrasound (FUS) is capable of modulating the neural activity of specific brain regions, with a potential role as a non-invasive computer-to-brain interface (CBI). In conjunction with the use of ... -
A Novel Approach of Groupwise fMRI-Guided Tractography Allowing to Characterize the Clinical Evolution of Alzheimer's Disease
(Public Library of Science, 2014)Guiding diffusion tract-based anatomy by functional magnetic resonance imaging (fMRI), we aim to investigate the relationship between structural connectivity and functional activity in the human brain. To this purpose, we ... -
A Physiologically Based Model of Orexinergic Stabilization of Sleep and Wake
(Public Library of Science, 2014)The orexinergic neurons of the lateral hypothalamus (Orx) are essential for regulating sleep-wake dynamics, and their loss causes narcolepsy, a disorder characterized by severe instability of sleep and wake states. However, ... -
The Problem of Thresholding in Small-World Network Analysis
(Public Library of Science, 2013)Graph theory deterministically models networks as sets of vertices, which are linked by connections. Such mathematical representation of networks, called graphs are increasingly used in neuroscience to model functional ... -
A Real-Time Brain-Machine Interface Combining Motor Target and Trajectory Intent Using an Optimal Feedback Control Design
(Public Library of Science, 2013)Real-time brain-machine interfaces (BMI) have focused on either estimating the continuous movement trajectory or target intent. However, natural movement often incorporates both. Additionally, BMIs can be modeled as a ... -
Synchronization of Isolated Downstates (K-Complexes) May Be Caused by Cortically-Induced Disruption of Thalamic Spindling
(Public Library of Science, 2014)Sleep spindles and K-complexes (KCs) define stage 2 NREM sleep (N2) in humans. We recently showed that KCs are isolated downstates characterized by widespread cortical silence. We demonstrate here that KCs can be ... -
Teaching the Blind to Find Their Way by Playing Video Games
(Public Library of Science, 2012)Computer based video games are receiving great interest as a means to learn and acquire new skills. As a novel approach to teaching navigation skills in the blind, we have developed Audio-based Environment Simulator (AbES); ... -
Using Pattern Classification to Measure Adaptation to the Orientation of High Order Aberrations
(Public Library of Science, 2013)Background: The image formed by the eye's optics is blurred by the ocular aberrations, specific to each eye. Recent studies demonstrated that the eye is adapted to the level of blur produced by the high order aberrations ...