Browsing Harvard Medical School by Keyword "Computer and Information Sciences"
Now showing items 1-20 of 50
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Approaches to Recording Drug Allergies in Electronic Health Records: Qualitative Study
(Public Library of Science, 2014)Background: Drug allergy represent an important subset of adverse drug reactions that is worthy of attention because many of these reactions are potentially preventable with use of computerised decision support systems. ... -
Are Maternal Social Networks and Perceptions of Trust Associated with Suspected Autism Spectrum Disorder in Offspring? A Population-Based Study in Japan
(Public Library of Science, 2014)Objective: To investigate the associations of maternal social networks and perceptions of trust with the prevalence of suspected autism spectrum disorders in 18-month-old offspring in Japan. Methods: Questionnaires included ... -
Assessing and Responding to Palliative Care Needs in Rural Sub-Saharan Africa: Results from a Model Intervention and Situation Analysis in Malawi
(Public Library of Science, 2014)Introduction: Palliative care is rarely accessible in rural sub-Saharan Africa. Partners In Health and the Malawi government established the Neno Palliative Care Program (NPCP) to provide palliative care in rural Neno ... -
Biological Time Series Analysis Using a Context Free Language: Applicability to Pulsatile Hormone Data
(Public Library of Science, 2014)We present a novel approach for analyzing biological time-series data using a context-free language (CFL) representation that allows the extraction and quantification of important features from the time-series. This ... -
Bipartite Community Structure of eQTLs
(Public Library of Science, 2016)Genome Wide Association Studies (GWAS) and expression quantitative trait locus (eQTL) analyses have identified genetic associations with a wide range of human phenotypes. However, many of these variants have weak effects ... -
C3-PRO: Connecting ResearchKit to the Health System Using i2b2 and FHIR
(Public Library of Science, 2016)A renewed interest by consumer information technology giants in the healthcare domain is focused on transforming smartphones into personal health data storage devices. With the introduction of the open source ResearchKit, ... -
CGBayesNets: Conditional Gaussian Bayesian Network Learning and Inference with Mixed Discrete and Continuous Data
(Public Library of Science, 2014)Bayesian Networks (BN) have been a popular predictive modeling formalism in bioinformatics, but their application in modern genomics has been slowed by an inability to cleanly handle domains with mixed discrete and continuous ... -
ClinicalTrials.gov as a Data Source for Semi-Automated Point-Of-Care Trial Eligibility Screening
(Public Library of Science, 2014)Background: Implementing semi-automated processes to efficiently match patients to clinical trials at the point of care requires both detailed patient data and authoritative information about open studies. Objective: To ... -
Combining Healthcare-Based and Participatory Approaches to Surveillance: Trends in Diarrheal and Respiratory Conditions Collected by a Mobile Phone System by Community Health Workers in Rural Nepal
(Public Library of Science, 2016)Background: Surveillance systems are increasingly relying upon community-based or crowd-sourced data to complement traditional facilities-based data sources. Data collected by community health workers during the routine ... -
Complex Breakpoints and Template Switching Associated with Non-canonical Termination of Homologous Recombination in Mammalian Cells
(Public Library of Science, 2016)A proportion of homologous recombination (HR) events in mammalian cells resolve by “long tract” gene conversion, reflecting copying of several kilobases from the donor sister chromatid prior to termination. Cells lacking ... -
Computational Reconstruction of NFκB Pathway Interaction Mechanisms during Prostate Cancer
(Public Library of Science, 2016)Molecular research in cancer is one of the largest areas of bioinformatic investigation, but it remains a challenge to understand biomolecular mechanisms in cancer-related pathways from high-throughput genomic data. This ... -
Computer Aided Diagnosis for Confocal Laser Endomicroscopy in Advanced Colorectal Adenocarcinoma
(Public Library of Science, 2016)Introduction: Confocal laser endomicroscopy (CLE) is becoming a popular method for optical biopsy of digestive mucosa for both diagnostic and therapeutic procedures. Computer aided diagnosis of CLE images, using image ... -
The Connectome Visualization Utility: Software for Visualization of Human Brain Networks
(Public Library of Science, 2014)In analysis of the human connectome, the connectivity of the human brain is collected from multiple imaging modalities and analyzed using graph theoretical techniques. The dimensionality of human connectivity data is high, ... -
Conscious Brain-to-Brain Communication in Humans Using Non-Invasive Technologies
(Public Library of Science, 2014)Human sensory and motor systems provide the natural means for the exchange of information between individuals, and, hence, the basis for human civilization. The recent development of brain-computer interfaces (BCI) has ... -
Determinants of Smoking and Quitting in HIV-Infected Individuals
(Public Library of Science, 2016)Background: Cigarette smoking is widespread among HIV-infected patients, who confront increased risk of smoking-related co-morbidities. The effects of HIV infection and HIV-related variables on smoking and smoking cessation ... -
Development, Calibration and Performance of an HIV Transmission Model Incorporating Natural History and Behavioral Patterns: Application in South Africa
(Public Library of Science, 2014)Understanding HIV transmission dynamics is critical to estimating the potential population-wide impact of HIV prevention and treatment interventions. We developed an individual-based simulation model of the heterosexual ... -
Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus
(Public Library of Science, 2016)Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the ... -
Disease Surveillance on Complex Social Networks
(Public Library of Science, 2016)As infectious disease surveillance systems expand to include digital, crowd-sourced, and social network data, public health agencies are gaining unprecedented access to high-resolution data and have an opportunity to ... -
Dynamics of the Microbiota in Response to Host Infection
(Public Library of Science, 2014)Longitudinal studies of the microbiota are important for discovering changes in microbial communities that affect the host. The complexity of these ecosystems requires rigorous integrated experimental and computational ... -
eduSPIM: Light Sheet Microscopy in the Museum
(Public Library of Science, 2016)Light Sheet Microscopy in the Museum Light sheet microscopy (or selective plane illumination microscopy) is an important imaging technique in the life sciences. At the same time, this technique is also ideally suited for ...