Now showing items 1-9 of 9

    • An Active Learning Approach for Rapid Characterization of Endothelial Cells in Human Tumors 

      Padmanabhan, Raghav K.; Somasundar, Vinay H.; Griffith, Sandra D.; Zhu, Jianliang; Samoyedny, Drew; Tan, Kay See; Hu, Jiahao; Liao, Xuejun; Carin, Lawrence; Yoon, Sam S.; Flaherty, Keith T.; DiPaola, Robert S.; Heitjan, Daniel F.; Lal, Priti; Feldman, Michael D.; Roysam, Badrinath; Lee, William M. F. (Public Library of Science, 2014)
      Currently, no available pathological or molecular measures of tumor angiogenesis predict response to antiangiogenic therapies used in clinical practice. Recognizing that tumor endothelial cells (EC) and EC activation and ...
    • Basal Gene Expression by Lung CD4+ T Cells in Chronic Obstructive Pulmonary Disease Identifies Independent Molecular Correlates of Airflow Obstruction and Emphysema Extent 

      Freeman, Christine M.; McCubbrey, Alexandra L.; Crudgington, Sean; Nelson, Joshua; Martinez, Fernando J.; Han, MeiLan K.; Washko, George R.; Chensue, Stephen W.; Arenberg, Douglas A.; Meldrum, Catherine A.; McCloskey, Lisa; Curtis, Jeffrey L. (Public Library of Science, 2014)
      Lung CD4+ T cells accumulate as chronic obstructive pulmonary disease (COPD) progresses, but their role in pathogenesis remains controversial. To address this controversy, we studied lung tissue from 53 subjects undergoing ...
    • Carbon Monoxide Abrogates Ischemic Insult to Neuronal Cells via the Soluble Guanylate Cyclase-cGMP Pathway 

      Schallner, Nils; Romão, Carlos C.; Biermann, Julia; Lagrèze, Wolf A.; Otterbein, Leo E.; Buerkle, Hartmut; Loop, Torsten; Goebel, Ulrich (Public Library of Science, 2013)
      Purpose Carbon monoxide (CO) is an accepted cytoprotective molecule. The extent and mechanisms of protection in neuronal systems have not been well studied. We hypothesized that delivery of CO via a novel releasing molecule ...
    • Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease 

      Longhi, Maria Serena; Moss, Alan; Bai, Aiping; Wu, Yan; Huang, Huang; Cheifetz, Adam; Quintana, Francisco J.; Robson, Simon C. (Public Library of Science, 2014)
      Induced regulatory T-cells (iT-reg) and T helper type 17 (Th17) in the mouse share common CD4 progenitor cells and exhibit overlapping phenotypic and functional features. Here, we show that human Th17 cells endowed with ...
    • Icariside II Induces Apoptosis in U937 Acute Myeloid Leukemia Cells: Role of Inactivation of STAT3-Related Signaling 

      Kang, Sang-Hun; Jeong, Soo-Jin; Kim, Sun-Hee; Kim, Ji-Hyun; Koh, Wonil; Kim, Sung-Hoon; Jung, Ji Hoon; Kim, Jung Hyo; Kim, Dae Keun; Chen, Chang-Yan (Public Library of Science, 2012)
      Background: The aim of this study is to determine anti-cancer effect of Icariside II purified from the root of Epimedium koreanum Nakai on human acute myeloid leukemia (AML) cell line U937. Methodology/Principal Findings ...
    • Increasing fMRI Sampling Rate Improves Granger Causality Estimates 

      Lin, Fa-Hsuan; Ahveninen, Jyrki; Raij, Tommi; Witzel, Thomas; Chu, Ying-Hua; Jääskeläinen, Iiro P.; Tsai, Kevin Wen-Kai; Kuo, Wen-Jui; Belliveau, John W. (Public Library of Science, 2014)
      Estimation of causal interactions between brain areas is necessary for elucidating large-scale functional brain networks underlying behavior and cognition. Granger causality analysis of time series data can quantitatively ...
    • Microcarrier-Based Expansion of Adult Murine Side Population Stem Cells 

      Pacak, Christina Ann; Eddy, Mau-Thek; Woodhull, Lindsey; Wang, Kai-Roy; Alpatov, Ivan; Fullen, Shelby; Dowd, Rory P.; Choi, Yeong-Hoon; Cowan, Douglas Burr (Public Library of Science, 2013)
      The lack of reliable methods to efficiently isolate and propagate stem cell populations is a significant obstacle to the advancement of cell-based therapies for human diseases. One isolation technique is based on efflux ...
    • A Novel Flow Cytometric HTS Assay Reveals Functional Modulators of ATP Binding Cassette Transporter ABCB6 

      Polireddy, Kishore; Khan, Mohiuddin Md. Taimur; Chavan, Hemantkumar; Young, Susan; Ma, Xiaochao; Waller, Anna; Garcia, Matthew; Perez, Dominique; Chavez, Stephanie; Strouse, Jacob J.; Haynes, Mark K.; Bologa, Cristian G.; Oprea, Tudor I.; Tegos, George; Sklar, Larry A.; Krishnamurthy, Partha (Public Library of Science, 2012)
      ABCB6 is a member of the adenosine triphosphate (ATP)-binding cassette family of transporter proteins that is increasingly recognized as a relevant physiological and therapeutic target. Evaluation of modulators of ABCB6 ...
    • P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death 

      Bian, Shu; Sun, Xiaofeng; Bai, Aiping; Zhang, Chunqing; Li, Lingling; Enjoji, Keiichi; Junger, Wolfgang G; Robson, Simon Christopher; Wu, Yan (Public Library of Science, 2013)
      Background: Extracellular adenosine triphosphate (ATP) functions as a novel danger signal that boosts antitumor immunity and can also directly kill tumor cells. We have previously reported that chronic exposure of tumor ...