Browsing Harvard Medical School by Keyword "Embryology"

Now showing items 1-12 of 12

    • Bmp7 Maintains Undifferentiated Kidney Progenitor Population and Determines Nephron Numbers at Birth 

      Tomita, Mayumi; Asada, Misako; Asada, Nariaki; Nakamura, Jin; Oguchi, Akiko; Higashi, Atsuko Y.; Endo, Shuichiro; Robertson, Elizabeth; Kimura, Takeshi; Kita, Toru; Economides, Aris N.; Kreidberg, Jordan; Yanagita, Motoko (Public Library of Science, 2013)
      The number of nephrons, the functional units of the kidney, varies among individuals. A low nephron number at birth is associated with a risk of hypertension and the progression of renal insufficiency. The molecular ...

    • Diffusion MRI Tractography of the Developing Human Fetal Heart 

      Mekkaoui, Choukri; Porayette, Prashob; Jackowski, Marcel P.; Kostis, William J.; Dai, Guangping; Sanders, Stephen; Sosnovik, David E. (Public Library of Science, 2013)
      Objective: Human myocardium has a complex and anisotropic 3D fiber pattern. It remains unknown, however, when in fetal life this anisotropic pattern develops and whether the human heart is structurally fully mature at ...

    • eduSPIM: Light Sheet Microscopy in the Museum 

      Jahr, Wiebke; Schmid, Benjamin; Weber, Michael; Huisken, Jan (Public Library of Science, 2016)
      Light Sheet Microscopy in the Museum Light sheet microscopy (or selective plane illumination microscopy) is an important imaging technique in the life sciences. At the same time, this technique is also ideally suited for ...

    • Embryonic Origin and Remodeling of the Urinary and Digestive Outlets 

      Wang, Cheng-yen; Wang, Jingying; Borer, Joseph G.; Li, Xue (Public Library of Science, 2013)
      Separating digestive and urinary outlets is a critical step during mammalian embryogenesis. However, the natural history of these structures is poorly studied, and little is known about their embryonic origin. Here, we ...

    • Live Pups from Evaporatively Dried Mouse Sperm Stored at Ambient Temperature for up to 2 Years 

      Liu, Jie; Lee, Gloria Y.; Lawitts, Joel A.; Toner, Mehmet; Biggers, John D. (Public Library of Science, 2014)
      The purpose of this study is to develop a mouse sperm preservation method based on evaporative drying. Mouse sperm were evaporatively dried and stored at 4°C and ambient temperature for 3 months to 2 years. Upon rehydration, ...

    • Middle Meningeal Artery Arising from the Basilar Artery 

      Salem, Mohamed M.; Fusco, Matthew R.; Dolati, Parviz; Reddy, Arra S.; Gross, Bradley A.; Ogilvy, Christopher S.; Thomas, Ajith J. (Korean Society of Cerebrovascular Surgeons; Society of Korean Endovascular Neurosurgeons, 2014)
      Various anomalies for the origin of the middle meningeal artery (MMA) have been described in the literature. However, origin of the MMA from the basilar trunk is an extremely rare variant. We report on a 54-year-old female ...

    • miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga 

      De Lella Ezcurra, Ana Laura; Bertolin, Agustina Paola; Kim, Kevin; Katz, Maximiliano Javier; Gándara, Lautaro; Misra, Tvisha; Luschnig, Stefan; Perrimon, Norbert; Melani, Mariana; Wappner, Pablo (Public Library of Science, 2016)
      Cellular and systemic responses to low oxygen levels are principally mediated by Hypoxia Inducible Factors (HIFs), a family of evolutionary conserved heterodimeric transcription factors, whose alpha- and beta-subunits ...

    • MiR-449a Affects Epithelial Proliferation during the Pseudoglandular and Canalicular Phases of Avian and Mammal Lung Development 

      Sanford, Ethan L.; Choy, Kwong W.; Donahoe, Patricia K.; Tracy, Adam A.; Hila, Regis; Loscertales, Maria; Longoni, Mauro (Public Library of Science, 2016)
      Congenital diaphragmatic hernia is associated with pulmonary hypoplasia and respiratory distress, which result in high mortality and morbidity. Although several transgenic mouse models of lung hypoplasia exist, the role ...

    • p600 Plays Essential Roles in Fetal Development 

      Nakaya, Takeo; Ishiguro, Kei-ichiro; Belzil, Camille; Rietsch, Anna M.; Yu, Qunyan; Mizuno, Shin-ichi; Bronson, Roderick T.; Geng, Yan; Nguyen, Minh Dang; Akashi, Koichi; Sicinski, Piotr; Nakatani, Yoshihiro (Public Library of Science, 2013)
      p600 is a multifunctional protein implicated in cytoskeletal organization, integrin-mediated survival signaling, calcium-calmodulin signaling and the N-end rule pathway of ubiquitin-proteasome-mediated proteolysis. While ...

    • Perinatal Natural History of the Ts1Cje Mouse Model of Down Syndrome: Growth Restriction, Early Mortality, Heart Defects, and Delayed Development 

      Ferrés, Millie A.; Bianchi, Diana W.; Siegel, Ashley E.; Bronson, Roderick T.; Huggins, Gordon S.; Guedj, Faycal (Public Library of Science, 2016)
      Background: The Ts1Cje model of Down syndrome is of particular interest for perinatal studies because affected males are fertile. This permits affected pups to be carried in wild-type females, which is similar to human ...

    • Slc39a7/zip7 Plays a Critical Role in Development and Zinc Homeostasis in Zebrafish 

      Yan, Guang; Zhang, Yuchao; Yu, Junlei; Zhang, Zhuzhen; Wu, Aimin; Yan, Xianghua; Wang, Fudi; Yu, Yu; Zhang, Fan; Zhou, Yi (Public Library of Science, 2012)
      Background: Slc39a7/Zip7, also known as Ke4, is a member of solute carrier family 39 (Slc39a) and plays a critical role in regulating cell growth and death. Because the function of Zip7 in vivo was unclear, the present ...

    • Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome 

      Klase, Zachary A.; Khakhina, Svetlana; Schneider, Adriano De Bernardi; Callahan, Michael V.; Glasspool-Malone, Jill; Malone, Robert (Public Library of Science, 2016)
      The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain–Barré syndrome) has brought attention to this ...