Browsing Harvard Medical School by Keyword "activation"
Now showing items 1-4 of 4
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Cockayne Syndrome Protein B Interacts with and Is Phosphorylated by c-Abl Tyrosine Kinase
(Oxford University Press, 2007)The Cockayne Syndrome group B (CSB) protein plays important roles in transcription, transcription-coupled nucleotide excision repair and base excision DNA repair. c-Abl kinase also plays a role in DNA repair as a ... -
Gene Expression-Based Screening for Inhibitors of PDGFR Signaling
(BioMed Central, 2008)Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high-throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth ... -
Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis
(Blackwell, 2014)Incorporation of locally produced signaling molecules into cell-derived vesicles may serve as an endogenous mediator delivery system. We recently reported that levels alpha-2-macroglobulin (A2MG)-containing microparticles ... -
Selenoproteins Regulate Macrophage Invasiveness and Extracellular Matrix-related Gene Expression
(BioMed Central, 2009)Background: Selenium, a micronutrient whose deficiency in diet causes immune dysfunction and inflammatory disorders, is thought to exert its physiological effects mostly in the form of selenium-containing proteins ...