Browsing Harvard Medical School by Keyword "antigen recognition"

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    • Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination 

      Brazin, Kristine N.; Mallis, Robert J.; Das, Dibyendu Kumar; Feng, Yinnian; Hwang, Wonmuk; Wang, Jia-huai; Wagner, Gerhard; Lang, Matthew J.; Reinherz, Ellis L. (Frontiers Media S.A., 2015)
      The αβTCR was recently revealed to function as a mechanoreceptor. That is, it leverages mechanical energy generated during immune surveillance and at the immunological synapse to drive biochemical signaling following ...

    • TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling 

      Kim, Sun Taek; Sun, Zhen-Yu Jim; Shin, Yongdae; Brazin, Kristine N.; Mallis, Robert J.; Wagner, Gerhard; Lang, Matthew J.; Reinherz, Ellis Leonard (Frontiers Research Foundation, 2012)
      Mechanotransduction is a basis for receptor signaling in many biological systems. Recent data based upon optical tweezer experiments suggest that the TCR is an anisotropic mechanosensor, converting mechanical energy into ...