Browsing Harvard Medical School by Keyword "basal ganglia"
Now showing items 1-7 of 7
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Gray Matter Injury Associated with Periventricular Leukomalacia in the Premature Infant
(Springer-Verlag, 2007)Neuroimaging studies indicate reduced volumes of certain gray matter regions in survivors of prematurity with periventricular leukomalacia (PVL). We hypothesized that subacute and/or chronic gray matter lesions are increased ... -
Imaging Studies in Focal Dystonias: A Systems Level Approach to Studying a Systems Level Disorder
(Bentham Science Publishers, 2013)Focal dystonias are dystonias that affect one part of the body, and are sometimes task-specific. Brain imaging and transcranial magnetic stimulation techniques have been valuable in defining the pathophysiology of dystonias ... -
The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons
(eLife Sciences Publications, Ltd, 2016)Certain neuron types fire spontaneously at high rates, an ability that is crucial for their function in brain circuits. The spontaneously active GABAergic neurons of the substantia nigra pars reticulata (SNr), a major ... -
Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis
(eLife Sciences Publications, Ltd, 2014)Synaptic transmission between midbrain dopamine neurons and target neurons in the striatum is essential for the selection and reinforcement of movements. Recent evidence indicates that nigrostriatal dopamine neurons inhibit ... -
Neuromodulation of excitatory synaptogenesis in striatal development
(eLife Sciences Publications, Ltd, 2015)Dopamine is released in the striatum during development and impacts the activity of Protein Kinase A (PKA) in striatal spiny projection neurons (SPNs). We examined whether dopaminergic neuromodulation regulates activity-dependent ... -
Neuronal activity (c-Fos) delineating interactions of the cerebral cortex and basal ganglia
(Frontiers Media S.A., 2014)The cerebral cortex and basal ganglia (BG) form a neural circuit that is disrupted in disorders such as Parkinson’s disease. We found that neuronal activity (c-Fos) in the BG followed cortical activity, i.e., high in arousal ... -
Shape of caudate nucleus and its cognitive correlates in neuroleptic-naive schizotypal personality disorder
(Elsevier BV, 2004)Background: We measured the shape of the head of the caudate nucleus with a new approach based on magnetic resonance imaging (MRI) in schizotypal personality disorder (SPD) subjects in whom we previously reported decreased ...