Now showing items 1-7 of 7

    • Aberrant Expression of Functional BAFF-System Receptors by Malignant B-Cell Precursors Impacts Leukemia Cell Survival 

      Maia, Sara; Pelletier, Marc; Ding, Jixin; Hsu, Yen-Ming; Sallan, Stephen Earl; Rao, Sambasiva P.; Nadler, Lee Marshall; Cardoso, Angelo A. (Public Library of Science, 2011)
      Despite exhibiting oncogenic events, patient's leukemia cells are responsive and dependent on signals from their malignant bone marrow (BM) microenvironment, which modulate their survival, cell cycle progression, trafficking ...
    • Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi's Sarcoma 

      Jham, Bruno C.; Ma, Tao; Hu, Jiadi; Chaisuparat, Risa; Friedman, Eitan R.; Pandolfi, Pier Paolo; Schneider, Abraham; Sodhi, Akrit; Montaner, Silvia (Public Library of Science, 2011)
      Background: Kaposi’s sarcoma (KS) is a vascular neoplasm characterized by the dysregulated expression of angiogenic and inflammatory cytokines. The driving force of the KS lesion, the KSHV-infected spindle cell, secretes ...
    • Angiogenic mRNA and microRNA Gene Expression Signature Predicts a Novel Subtype of Serous Ovarian Cancer 

      Risch, Thomas; Fan, Jian-Bing; Holton, Kristina; Rubio, Renee; April, Craig; Wickham-Garcia, Eliza; Bentink, Stefan; Haibe-Kains, Benjamin; Hirsch, Michelle S.; Chen, Jing; Liu, Joyce; Culhane, Aedin; Drapkin, Ronny I.; Quackenbush, John; Matulonis, Ursula Anne (Public Library of Science, 2012)
      Ovarian cancer is the fifth leading cause of cancer death for women in the U.S. and the seventh most fatal worldwide. Although ovarian cancer is notable for its initial sensitivity to platinum-based therapies, the vast ...
    • canEvolve: A Web Portal for Integrative Oncogenomics 

      Samur, Mehmet Kemal; Yan, Zhenyu; Wang, Xujun; Cao, Qingyi; Munshi, Nikhil C.; Li, Cheng; Shah, Parantu K. (Public Library of Science, 2013)
      Background & objective: Genome-wide profiles of tumors obtained using functional genomics platforms are being deposited to the public repositories at an astronomical scale, as a result of focused efforts by individual ...
    • Impact of Circulating Cholesterol Levels on Growth and Intratumoral Androgen Concentration of Prostate Tumors 

      Mostaghel, Elahe A.; Solomon, Keith R.; Pelton, Kristine; Freeman, Michael R.; Montgomery, R. Bruce (Public Library of Science, 2012)
      Prostate cancer (PCa) is the second most common cancer in men. Androgen deprivation therapy (ADT) leads to tumor involution and reduction of tumor burden. However, tumors eventually reemerge that have overcome the absence ...
    • Lung Adenocarcinoma of Never Smokers and Smokers Harbor Differential Regions of Genetic Alteration and Exhibit Different Levels of Genomic Instability 

      Thu, Kelsie L.; Vucic, Emily A.; Lockwood, William W.; English, John C.; Fu, Rong; Feng, Ziding; MacAulay, Calum E.; Gazdar, Adi F.; Lam, Wan L.; Chari, Rajagopal; Zhang, Wei; Wang, Pei; Lam, Stephen (Public Library of Science, 2012)
      Recent evidence suggests that the observed clinical distinctions between lung tumors in smokers and never smokers (NS) extend beyond specific gene mutations, such as EGFR, EML4-ALK, and KRAS, some of which have been ...
    • Recurrent Chromosomal Copy Number Alterations in Sporadic Chordomas 

      Le, Long Phi; Nielsen, Gunnlaugur Petur; Rosenberg, Andrew Eric; Thomas, Dafydd; Batten, Julie M.; Deshpande, Vikram; Schwab, Joseph H; Duan, Zhenfeng; Xavier, Ramnik; Hornicek, Francis John; Iafrate, Anthony John (Public Library of Science, 2011)
      The molecular events in chordoma pathogenesis have not been fully delineated, particularly with respect to copy number changes. Understanding copy number alterations in chordoma may reveal critical disease mechanisms that ...