Browsing Harvard Medical School by Keyword "biomactomolecule-ligand interactions"

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    • Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening 

      Cabrol, Christelle; Huzarska, Malwina A.; Dinolfo, Christopher; Rodriguez, Maria C.; Reinstatler, Lael; Ni, Jake; Yeh, Li-An; Stein, Ross L.; Leissring, Malcolm A.; Cuny, Gregory Douglas; Selkoe, Dennis J. (Public Library of Science, 2009)
      Background: Hypocatabolism of the amyloid β-protein (Aβ) by insulin-degrading enzyme (IDE) is implicated in the pathogenesis of Alzheimer disease (AD), making pharmacological activation of IDE an attractive therapeutic ...