Browsing Harvard Medical School by Keyword "bone"
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Dinosaur Peptides Suggest Mechanisms of Protein Survival
(Public Library of Science, 2011)Eleven collagen peptide sequences recovered from chemical extracts of dinosaur bones were mapped onto molecular models of the vertebrate collagen fibril derived from extant taxa. The dinosaur peptides localized to fibril ... -
Effects of Age-Related Differences in Femoral Loading and Bone Mineral Density on Strains in the Proximal Femur during Controlled Walking
(Human Kinetics, 2013)Maintenance of healthy bone mineral density (BMD) is important for preventing fractures in older adults. Strains experienced by bone in vivo stimulate remodeling processes, which can increase or decrease BMD. However, there ... -
Fetal Lead Exposure at Each Stage of Pregnancy as a Predictor of Infant Mental Development
(National Institute of Environmental Health Sciences, 2006)Background: The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure. Objective: We ... -
Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production
(2015)Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with chronic kidney disease (CKD), but the mechanisms are poorly understood. Here we tested whether inflammation and iron deficiency regulate ... -
SIRT1 Regulates Differentiation of Mesenchymal Stem Cells by Deacetylating β-Catenin
(WILEY-VCH Verlag, 2013)Mesenchymal stem cells (MSCs) are multi-potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a ...