Browsing Harvard Medical School by Keyword "brain region"
Now showing items 1-2 of 2
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A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression
(Landes Bioscience, 2013)Brain cellular heterogeneity may bias cell type specific DNA methylation patterns, influencing findings in psychiatric epigenetic studies. We performed fluorescence activated cell sorting (FACS) of neuronal nuclei and ... -
Measuring cell-type specific differential methylation in human brain tissue
(BioMed Central, 2013)The behavior of epigenetic mechanisms in the brain is obscured by tissue heterogeneity and disease-related histological changes. Not accounting for these confounders leads to biased results. We develop a statistical ...