Browsing Harvard Medical School by Keyword "breast cancer"

Now showing items 1-20 of 55

    • The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer 

      Cotter, Kristina; Liberman, Rachel; Sun-Wada, GeHong; Wada, Yoh; Sgroi, Dennis; Naber, Stephen; Brown, Dennis; Breton, Sylvie; Forgac, Michael (Impact Journals LLC, 2016)
      The vacuolar (H+)-ATPases (V-ATPases) are a family of ATP-driven proton pumps that acidify intracellular compartments and transport protons across the plasma membrane. Previous work has demonstrated that plasma membrane ...

    • Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment 

      Herter-Sprie, Grit S.; Greulich, Heidi E.; Wong, Kwok-Kin (Frontiers Media S.A., 2013)
      Despite the ongoing “war on cancer,” cancer remains one of the major causes of human morbidity and mortality. A new paradigm of targeted therapies holds the most promise for the future, making identification of tumor-specific ...

    • Adolescent diet and risk of breast cancer 

      Frazier, A. Lindsay; Ryan, Catherine Tomeo; Rockett, Helaine; Willett, Walter C.; Colditz, Graham A. (BioMed Central, 2003)
      Background: Early life exposures, including diet, have been implicated in the etiology of breast cancer. Methods: A nested case-control study was conducted among participants in the Nurses' Health Study who completed a ...

    • Advanced Breast Imaging Availability by Screening Facility Characteristics 

      Lee, Christoph I.; Bogart, Andy; Hubbard, Rebecca A.; Obadina, Eniola T.; Hill, Deirdre A.; Haas, Jennifer S.; Tosteson, Anna N.A.; Alford-Teaster, Jennifer A.; Sprague, Brian L.; DeMartini, Wendy B.; Lehman, Constance D; Onega, Tracy L. (Elsevier BV, 2015)
      RATIONALE AND OBJECTIVES: To determine the relationship between screening mammography facility characteristics and on-site availability of advanced breast imaging services required for supplemental screening and the ...

    • Alcohol Intake and Mortality among Women with Invasive Breast Cancer 

      Harris, Holly Ruth; Bergkvist, L; Wolk, A (Nature Publishing Group, 2012)
      Background: Alcohol intake has consistently been associated with increased breast cancer incidence in epidemiological studies. However, the relation between alcohol and survival after breast cancer diagnosis is less clear. ...

    • Associations between Polycyclic Aromatic Hydrocarbon–Related Exposures and p53 Mutations in Breast Tumors 

      Mordukhovich, Irina; Rossner, Pavel; Terry, Mary Beth; Santella, Regina; Zhang, Yu-Jing; Hibshoosh, Hanina; Memeo, Lorenzo; Mansukhani, Mahesh; Long, Chang-Min; Garbowski, Gail; Agrawal, Meenakshi; Gaudet, Mia M.; Steck, Susan E.; Eng, Sybil M.; Teitelbaum, Susan L.; Neugut, Alfred I.; Conway-Dorsey, Kathleen; Gammon, Marilie D.; Sagiv, Sharon Karnit (National Institute of Environmental Health Sciences, 2010)
      Background: Previous studies have suggested that polycyclic aromatic hydrocarbons (PAHs) may be associated with breast cancer. However, the carcinogenicity of PAHs on the human breast remains unclear. Certain carcinogens ...

    • A Breast Cancer Meta-Analysis of Two Expression Measures of Chromosomal Instability Reveals a Relationship with Younger Age at Diagnosis and High Risk Histopathological Variables 

      Endesfelder, David; McGranahan, Nicholas; Birkbak, Nicolai Juul; Szallasi, Zoltan; Kschischo, Maik; Graham, Trevor A.; Swanton, Charles (Impact Journals LLC, 2011)
      Breast cancer in younger patients often presents with adverse histopathological features, including increased frequency of estrogen receptor negative and lymph node positive disease status. Chromosomal instability (CIN) ...

    • Breast cancer screening in an era of personalized regimens: A conceptual model and National Cancer Institute initiative for risk-based and preference-based approaches at a population level 

      Onega, Tracy; Beaber, Elisabeth F.; Sprague, Brian L.; Barlow, William E.; Haas, Jennifer S.; Tosteson, Anna N.A.; D. Schnall, Mitchell; Armstrong, Katrina Alison; Schapira, Marilyn M.; Geller, Berta; Weaver, Donald L.; Conant, Emily F. (Wiley-Blackwell, 2014)
      Breast cancer screening holds a prominent place in public health, health care delivery, policy, and women's health care decisions. Several factors are driving shifts in how population-based breast cancer screening is ...

    • CK1\(\varepsilon\) is Required for Breast Cancers Dependent on \(\beta\)-Catenin Activity 

      Firestein, Ron; Gupta, Piyush; Repich, Kara; Silver, Serena J.; Boehm, Jesse S.; Kim, So Young; Dunn, Ian Frederick; Wardwell, Leslie; Schinzel, Anna; Wittner, Ben; Root, David E.; Ramaswamy, Sridhar; Lander, Eric Steven; Hahn, William C. (Public Library of Science, 2010)
      Background: Aberrant \(\beta\)-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate \(\beta\)-catenin activity for therapeutic purposes have ...

    • Classical pathology and mutational load of breast cancer – integration of two worlds 

      Budczies, Jan; Bockmayr, Michael; Denkert, Carsten; Klauschen, Frederick; Lennerz, Jochen K; Györffy, Balázs; Dietel, Manfred; Loibl, Sibylle; Weichert, Wilko; Stenzinger, Albrecht (John Wiley and Sons Inc., 2015)
      Abstract Breast cancer is a complex molecular disease comprising several biological subtypes. However, daily routine diagnosis is still based on a small set of well‐characterized clinico‐pathological variables. Here, we ...

    • Clinical practice patterns and cost effectiveness of human epidermal growth receptor 2 testing strategies in breast cancer patients 

      Phillips, Kathryn A.; Marshall, Deborah A.; Haas, Jennifer S.; Elkin, Elena B.; Liang, Su-Ying; Hassett, Michael James; Ferrusi, Ilia; Brock, Jane Elizabeth; Van Bebber, Stephanie L. (Wiley-Blackwell, 2009)
      BACKGROUND: Testing technologies are increasingly used to target cancer therapies. Human epidermal growth factor receptor 2 (HER2) testing to target trastuzumab for patients with breast cancer provides insights into the ...

    • Combining Gene Expression Data from Different Generations of Oligonucleotide Arrays 

      Hwang, Kyu-Baek; Kong, Sek Won; Greenberg, Steven A.; Park, Peter J. (BioMed Central, 2004)
      Background: One of the important challenges in microarray analysis is to take full advantage of previously accumulated data, both from one's own laboratory and from public repositories. Through a comparative analysis on a ...

    • Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case–control study 

      Tamimi, Rulla May; Hankinson, Susan Elizabeth; Spiegelman, Donna Lynn; Kraft, Peter; Colditz, Graham A.; Hunter, David J. (BioMed Central, 2004)
      Introduction: The ataxia telangiectasia mutated (ATM) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of DNA double-strand breaks. Based on family studies, women heterozygous for ...

    • A Comparative Analysis of Genetic and Epigenetic Events of Breast and Ovarian Cancer Related to Tumorigenesis 

      Longacre, Mckenna; Snyder, Nicole A.; Housman, Genevieve; Leary, Meghan; Lapinska, Karolina; Heerboth, Sarah; Willbanks, Amber; Sarkar, Sibaji (MDPI, 2016)
      Breast cancer persists as the most common cause of cancer death in women worldwide. Ovarian cancer is also a significant source of morbidity and mortality, as the fifth leading cause of cancer death among women. This ...

    • Comparison of CE-FDG-PET/CT with CE-FDG-PET/MR in the evaluation of osseous metastases in breast cancer patients 

      Catalano, O A; Nicolai, E; Rosen, B R; Luongo, A; Catalano, M; Iannace, C; Guimaraes, A; Vangel, M G; Mahmood, U; Soricelli, A; Salvatore, M (Nature Publishing Group, 2015)
      Background: Despite improvements in treatments, metastatic breast cancer remains difficult to cure. Bones constitute the most common site of first-time recurrence, occurring in 40–75% of cases. Therefore, evaluation for ...

    • Contributions of integrin-linked kinase to breast cancer metastasis and tumourigenesis 

      Hinton, Cimona V; Avraham, Shalom; Avraham, Hava Karsenty (Blackwell Publishing Ltd, 2008)
      Abstract Metastasis contributes to more than 90% of mortality in breast cancer. Critical stages in the development of aggressive breast cancer include growth of the primary tumours, and their abilities to spread to distant ...

    • Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer 

      Li, Dongping; Ilnytskyy, Yaroslav; Kovalchuk, Anna; Khachigian, Levon M.; Bronson, Roderick T.; Wang, Bo; Kovalchuk, Olga (Impact Journals LLC, 2013)
      Transcriptional regulation of miRNAs that control the pathogenesis of breast cancer remains largely unknown. Here, we showed that ionizing radiation, a known breast carcinogen, triggered the differential expression of ...

    • Differential expression of neurogenes among breast cancer subtypes identifies high risk patients 

      Fernández-Nogueira, Patricia; Bragado, Paloma; Almendro, Vanessa; Ametller, Elisabet; Rios, Jose; Choudhury, Sibgat; Mancino, Mario; Gascón, Pedro (Impact Journals LLC, 2016)
      The nervous system is now recognized to be a relevant component of the tumor microenvironment. Receptors for neuropeptides and neurotransmitters have been identified in breast cancer. However, very little is known about ...

    • Endogenous sex steroids in premenopausal women and risk of breast cancer: the ORDET cohort 

      Schernhammer, Eva S; Sperati, Francesca; Razavi, Pedram; Agnoli, Claudia; Sieri, Sabina; Berrino, Franco; Krogh, Vittorio; Abbagnato, Carlo Alberto; Grioni, Sara; Blandino, Giovanni; Schunemann, Holger J; Muti, Paola (BioMed Central, 2013)
      Introduction: Previous studies showed that higher testosterone levels are associated with greater risk of breast cancer in premenopausal women, but the literature is scant and inconsistent. Methods: In a prospective nested ...

    • An epigenomic approach to therapy for tamoxifen-resistant breast cancer 

      Feng, Qin; Zhang, Zheng; Shea, Martin J; Creighton, Chad J; Coarfa, Cristian; Hilsenbeck, Susan G; Lanz, Rainer; He, Bin; Wang, Lei; Fu, Xiaoyong; Nardone, Agostina; Song, Yongcheng; Bradner, James; Mitsiades, Nicholas; Mitsiades, Constantine S; Osborne, C Kent; Schiff, Rachel; O'Malley, Bert W (Nature Publishing Group, 2014)
      Tamoxifen has been a frontline treatment for estrogen receptor alpha (ERα)-positive breast tumors in premenopausal women. However, resistance to tamoxifen occurs in many patients. ER still plays a critical role in the ...