Now showing items 1-3 of 3

    • BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations 

      Costa, Daniel Botelho; Halmos, Balázs; Kumar, Amit; Schumer, Susan T; Huberman, Mark Stephen; Boggon, Titus J; Tenen, Daniel Geoffrey; Kobayashi, Susumu (Public Library of Science, 2007)
      Background: Epidermal growth factor receptor (EGFR) mutations are present in the majority of patients with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib or erlotinib. ...
    • Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies 

      Thun, Michael J; Hannan, Lindsay M; Adams-Campbell, Lucile L; Flanders, W. Dana; Jee, Sun Ha; Katanoda, Kota; Kolonel, Laurence N; Marugame, Tomomi; Palmer, Julie R; Riboli, Elio; Sobue, Tomotaka; Avila-Tang, Erika; Wilkens, Lynne R; Samet, Jon M; Bofetta, Paolo; Buring, Julie Elizabeth; Feskanich, Diane; Lee, I-Min (Public Library of Science, 2008)
      Background: Better information on lung cancer occurrence in lifelong nonsmokers is needed to understand gender and racial disparities and to examine how factors other than active smoking influence risk in different time ...
    • Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants 

      Chen, Tzu-Hsiu; Feng, Whei; Jänne, Pasi A; Alvarez, James V; Zappaterra, Mauro; Bulmer, Sara E; Sellers, William R; Greulich, Heidi E.; Frank, David Alan; Hahn, William C.; Meyerson, Matthew Langer (Public Library of Science, 2005)
      Background: Somatic mutations in the kinase domain of the epidermal growth factor receptor tyrosine kinase gene EGFR are common in lung adenocarcinoma. The presence of mutations correlates with tumor sensitivity to the ...