Browsing Harvard Medical School by Keyword "cell differentiation"
Now showing items 1-8 of 8
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Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells
(Public Library of Science, 2008)Background: Pluripotent embryonic stem (ES) cells, which have the capacity to give rise to all tissue types in the body, show great promise as a versatile source of cells for regenerative therapy. However, the basic ... -
Evaluation of Silk Biomaterials in Combination with Extracellular Matrix Coatings for Bladder Tissue Engineering with Primary and Pluripotent Cells
(Public Library of Science, 2013)Silk-based biomaterials in combination with extracellular matrix (ECM) coatings were assessed as templates for cell-seeded bladder tissue engineering approaches. Two structurally diverse groups of silk scaffolds were ... -
GC-rich sequence elements recruit PRC2 in mammalian ES cells
(Public Library of Science, 2010)Polycomb proteins are epigenetic regulators that localize to developmental loci in the early embryo where they mediate lineage-specific gene repression. In Drosophila, these repressors are recruited to sequence elements ... -
Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions
(Public Library of Science, 2011)Nodal and Activin are morphogens of the TGFbeta superfamily of signaling molecules that direct differential cell fate decisions in a dose- and distance-dependent manner. During early embryonic development the Nodal/Activin ... -
In Vivo Analysis of the Notch Receptor S1 Cleavage
(Public Library of Science, 2009)A ligand-independent cleavage (S1) in the extracellular domain of the mammalian Notch receptor results in what is considered to be the canonical heterodimeric form of Notch on the cell surface. The in vivo consequences and ... -
Matricellular Signal Transduction Involving Calmodulin in the Social Amoebozoan Dictyostelium
(MDPI, 2013)The social amoebozoan Dictyostelium discoideum undergoes a developmental sequence wherein an extracellular matrix (ECM) sheath surrounds a group of differentiating cells. This sheath is comprised of proteins and carbohydrates, ... -
Novel Secretion Apparatus Maintains Spore Integrity and Developmental Gene Expression in Bacillus subtilis
(Public Library of Science, 2009)Sporulation in Bacillus subtilis involves two cells that follow separate but coordinately regulated developmental programs. Late in sporulation, the developing spore (the forespore) resides within a mother cell. The ... -
The Synergistic Regulatory Effect of Runx2 and MEF Transcription Factors on Osteoblast Differentiation Markers
(Korean Academy of Periodontology, 2010)Purpose: Bone tissues for clinical application can be improved by studies on osteoblast differentiation. Runx2 is known to be an important transcription factor for osteoblast differentiation. However, bone morphogenetic ...