Browsing Harvard Medical School by Keyword "cell proliferation"

Now showing items 1-4 of 4

    • Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells 

      Bang, Jeyoung; Huh, Jang Hoe; Na, Ji-Woon; Lu, Qiao; Carlson, Bradley A.; Tobe, Ryuta; Tsuji, Petra A.; Gladyshev, Vadim N.; Hatfield, Dolph L.; Lee, Byeong Jae (Korean Society for Molecular and Cellular Biology, 2015)
      The 15-kDa selenoprotein (Sep15) is a selenoprotein residing in the lumen of the endoplasmic reticulum (ER) and implicated in quality control of protein folding. Herein, we established an inducible RNAi cell line that ...

    • Corneal epithelial proliferation and thickness in a mouse model of dry eye 

      Fabiani, Claudia; Barabino, Stefano; Rashid, Saadia; Dana, Reza (Elsevier BV, 2009)
      Although several studies have previously focused on the conjunctival epithelial response to surface dryness, little is known about the effect of a dry environment on corneal epithelium, which is the most clinically significant ...

    • Ebp1 Sumoylation, Regulated by TLS/FUS E3 Ligase, Is Required for Its Anti-Proliferative Activity 

      Oh, S.-M.; Liu, Z.; Okada, M.; Jang, S.-W.; Liu, X.; Chan, C.-B.; Luo, Hongbo; Ye, K. (Nature Publishing Group, 2010)
      Ebp1, an ErbB3 receptor-binding protein, inhibits cell proliferation and acts as a putative tumor suppressor. Ebp1 translocates into the nucleus and functions as a transcription co-repressor for E2F-1. Here, we show that ...

    • In Vivo Regulation of E2F1 by Polycomb Group Genes in Drosophila 

      Ji, Jun-Yuan; Miles, Wayne O.; Korenjak, Michael; Zheng, Yani; Dyson, Nicholas J. (Genetics Society of America, 2012)
      The E2F transcription factors are important regulators of the cell cycle whose function is commonly misregulated in cancer. To identify novel regulators of E2F1 activity in vivo, we used Drosophila to conduct genetic ...